{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:38:42Z","timestamp":1792784322462,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":694,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"COPEV Associazione per la Prevenzione e Cura dell'Epatite Virale \u201cBeatrice Vitiello\u201d ONLUS"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.scr.2013.03.002","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T03:32:30Z","timestamp":1364355150000},"page":"563-573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants"],"prefix":"10.1016","volume":"11","author":[{"given":"Roberto","family":"Gramignoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veysel","family":"Tahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dorko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen J.","family":"Skvorak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc C.","family":"Hansel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Venkataramanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa C.S.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Jorns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Goran","family":"Ericzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Rosenborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Kuiper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle A.","family":"Soltys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George V.","family":"Mazariegos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira J.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Grompe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Strom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2013.03.002_bb0110","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nbt1326","article-title":"Robust expansion of human hepatocytes in Fah\u2212\/\u2212\/Rag2\u2212\/\u2212\/Il2rg\u2212\/\u2212 mice","volume":"25","author":"Azuma","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.scr.2013.03.002_bb0130","doi-asserted-by":"crossref","first-page":"e18222","DOI":"10.1371\/journal.pone.0018222","article-title":"Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience","volume":"6","author":"Bhogal","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.scr.2013.03.002_bb0040","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10545-006-0245-8","article-title":"Hepatocyte transplantation for liver-based metabolic disorders","volume":"29","author":"Dhawan","year":"2006","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.scr.2013.03.002_bb0075","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1124\/dmd.106.009670","article-title":"Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts","volume":"34","author":"Donato","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.scr.2013.03.002_bb0080","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.transproceed.2008.03.020","article-title":"Domino liver transplantation: risks and benefits","volume":"40","author":"Ericzon","year":"2008","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.scr.2013.03.002_bb0015","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/01.tp.0000231689.44266.ac","article-title":"Human hepatocyte transplantation: worldwide results","volume":"82","author":"Fisher","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.scr.2013.03.002_bb0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00007890-200001270-00018","article-title":"Defining hepatocellular chimerism in a liver failure patient bridged with hepatocyte infusion","volume":"69","author":"Fisher","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.scr.2013.03.002_bb0025","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199805143382004","article-title":"Treatment of the Crigler\u2013Najjar syndrome type I with hepatocyte transplantation","volume":"338","author":"Fox","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.scr.2013.03.002_bb0100","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3727\/096368911X600939","article-title":"Development and application of purified dissociation enzyme mixtures for human hepatocyte isolation","volume":"21","author":"Gramignoli","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.scr.2013.03.002_bb0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1124\/jpet.300.2.355","article-title":"The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes","volume":"300","author":"Hines","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.scr.2013.03.002_bb0030","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1542\/peds.111.6.1262","article-title":"Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder","volume":"111","author":"Horslen","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.scr.2013.03.002_bb0070","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/lt.20732","article-title":"Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation","volume":"12","author":"Hughes","year":"2006","journal-title":"Liver Transpl."},{"key":"10.1016\/j.scr.2013.03.002_bb0105","first-page":"887","article-title":"The use of human hepatocyte cultures to study the induction of cytochrome P-450","volume":"27","author":"Kostrubsky","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.scr.2013.03.002_bb0050","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3727\/000000007783465019","article-title":"Hepatocyte transplantation for glycogen storage disease type Ib","volume":"16","author":"Lee","year":"2007","journal-title":"Cell Transplant."},{"key":"10.1016\/j.scr.2013.03.002_bb0085","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jpeds.2011.06.033","article-title":"Liver transplantation for classical maple syrup urine disease: long-term follow-up in 37 patients and comparative united network for organ sharing experience","volume":"160","author":"Mazariegos","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.scr.2013.03.002_bb0055","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3727\/096368909X470775","article-title":"Liver cell transplantation: basic investigations for safe application in infants and small children","volume":"18","author":"Meyburg","year":"2009","journal-title":"Cell Transplant."},{"key":"10.1016\/j.scr.2013.03.002_bb0065","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/TP.0b013e318199936a","article-title":"One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects","volume":"87","author":"Meyburg","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.scr.2013.03.002_bb0060","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1097\/01.TP.0000122224.98318.19","article-title":"One liver, three recipients: segment IV from split-liver procedures as a source of hepatocytes for cell transplantation","volume":"77","author":"Mitry","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.scr.2013.03.002_bb0035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0140-6736(02)07529-3","article-title":"Hepatocyte transplantation as a treatment for glycogen storage disease type 1a","volume":"359","author":"Muraca","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.scr.2013.03.002_bb0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/lt.22443","article-title":"Domino liver transplantation: how far can we push the paradigm?","volume":"18","author":"Popescu","year":"2012","journal-title":"Liver Transpl."},{"key":"10.1016\/j.scr.2013.03.002_bb0095","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1432-2277.2011.01225.x","article-title":"The European experience","volume":"24","author":"Roels","year":"2011","journal-title":"Transpl. Int."},{"key":"10.1016\/j.scr.2013.03.002_bb0045","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1053\/j.gastro.2006.01.008","article-title":"Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency","volume":"130","author":"Stephenne","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.scr.2013.03.002_bb0135","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.3727\/096368912X653255","article-title":"Hepatocyte transplantation using the domino concept on a child with tetrabiopterin nonresponsive phenylketonuria","volume":"21","author":"Stephenne","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.scr.2013.03.002_bb0005","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00007890-199702270-00014","article-title":"Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure","volume":"63","author":"Strom","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.scr.2013.03.002_bb0020","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.3727\/000000006783982395","article-title":"Hepatocyte transplantation: clinical experience and potential for future use","volume":"15","author":"Strom","year":"2006","journal-title":"Cell Transplant."},{"key":"10.1016\/j.scr.2013.03.002_bb0125","author":"Tolando"},{"key":"10.1016\/j.scr.2013.03.002_bb0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00534-007-1299-1","article-title":"Domino liver transplantation","volume":"15","author":"Wilczek","year":"2008","journal-title":"J. Hepatobiliary Pancreat. Surg."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506113000287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506113000287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T14:03:41Z","timestamp":1539785021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506113000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1873506113000287"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2013.03.002","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2013.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}