{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:05:27Z","timestamp":1786993527992,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.scr.2015.01.008","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T08:12:15Z","timestamp":1422951135000},"page":"211-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells"],"prefix":"10.1016","volume":"14","author":[{"given":"Chuan-Chuan","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Shyan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Liang","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2015.01.008_bb0005","first-page":"1956","article-title":"Neovascularization induced growth of implanted C6 glioma multicellular spheroids: magnetic resonance microimaging","volume":"55","author":"Abramovitch","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.scr.2015.01.008_bb0010","doi-asserted-by":"crossref","first-page":"21099","DOI":"10.1073\/pnas.1112063108","article-title":"MicroRNA-34a regulates neurite outgrowth, spinal morphology, and function","volume":"108","author":"Agostini","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scr.2015.01.008_bb0015","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1242\/dev.02073","article-title":"MicroRNA functions in animal development and human disease","volume":"132","author":"Alvarez-Garcia","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.scr.2015.01.008_bb0020","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S0317167100043468","article-title":"A simple and reproducible experimental in vivo glioma model","volume":"8","author":"Auer","year":"1981","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.scr.2015.01.008_bb0025","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/glia.20694","article-title":"Molecular basis of oncostatin M-induced SOCS-3 expression in astrocytes","volume":"56","author":"Baker","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.scr.2015.01.008_bb0030","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.161.3839.370","article-title":"Differentiated rat glial cell strain in tissue culture","volume":"161","author":"Benda","year":"1968","journal-title":"Science"},{"key":"10.1016\/j.scr.2015.01.008_bb0035","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1227\/00006123-199004000-00010","article-title":"C6 glioma cell invasion and migration of rat brain after neural homografting: ultrastructure","volume":"26","author":"Bernstein","year":"1990","journal-title":"Neurosurgery"},{"key":"10.1016\/j.scr.2015.01.008_bb0040","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1227\/00006123-199105000-00003","article-title":"C6 glioma-astrocytoma cell and fetal astrocyte migration into artificial basement membrane: a permissive substrate for neural tumors but not fetal astrocytes","volume":"28","author":"Bernstein","year":"1991","journal-title":"Neurosurgery"},{"key":"10.1016\/j.scr.2015.01.008_bb0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.278.5337.477","article-title":"Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway","volume":"278","author":"Bonni","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.scr.2015.01.008_bb0050","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1182\/blood-2012-04-423004","article-title":"The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis","volume":"120","author":"Bridge","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.scr.2015.01.008_bb0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","article-title":"microRNA functions","volume":"23","author":"Bushati","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.scr.2015.01.008_bb0060","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1158\/0008-5472.CAN-06-0800","article-title":"MicroRNA-cancer connection: the beginning of a new tale","volume":"66","author":"Calin","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.scr.2015.01.008_bb0065","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers","volume":"6","author":"Calin","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.scr.2015.01.008_bb0070","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1471-4159.2006.03890.x","article-title":"Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells","volume":"98","author":"Cao","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.scr.2015.01.008_bb0075","doi-asserted-by":"crossref","first-page":"e60317","DOI":"10.1371\/journal.pone.0060317","article-title":"miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.scr.2015.01.008_bb0080","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3171\/jns.1995.83.4.0665","article-title":"Invading C6 glioma cells maintaining tumorigenicity","volume":"83","author":"Chicoine","year":"1995","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.scr.2015.01.008_bb0085","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.bbrc.2005.07.030","article-title":"Extensive modulation of a set of microRNAs in primary glioblastoma","volume":"334","author":"Ciafre","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scr.2015.01.008_bb0090","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.stem.2010.02.015","article-title":"MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors","volume":"6","author":"Delaloy","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.scr.2015.01.008_bb0095","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1208\/s12248-009-9147-7","article-title":"MicroRNA regulation of cancer stem cells and therapeutic implications","volume":"11","author":"DeSano","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.scr.2015.01.008_bb0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2009.10.020","article-title":"MicroRNAs potentiate neural development","volume":"64","author":"Fineberg","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.scr.2015.01.008_bb0105","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1002\/jcb.23106","article-title":"MicroRNA expression during osteogenic differentiation of human multipotent mesenchymal stromal cells from bone marrow","volume":"112","author":"Gao","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.scr.2015.01.008_bb0110","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/cdd.2009.71","article-title":"MicroRNAs and glioblastoma; the stem cell connection","volume":"17","author":"Godlewski","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.scr.2015.01.008_bb0115","doi-asserted-by":"crossref","first-page":"D154","DOI":"10.1093\/nar\/gkm952","article-title":"miRBase: tools for microRNA genomics","volume":"36","author":"Griffiths-Jones","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scr.2015.01.008_bb0120","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1053\/j.gastro.2008.12.006","article-title":"The microRNA-30 family is required for vertebrate hepatobiliary development","volume":"136","author":"Hand","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.scr.2015.01.008_bb0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00441-007-0530-3","article-title":"microRNA and stem cell function","volume":"331","author":"Hatfield","year":"2008","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.scr.2015.01.008_bb0130","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/stem.288","article-title":"MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation","volume":"28","author":"Huang","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.scr.2015.01.008_bb0135","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4161\/rna.8.5.16153","article-title":"MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2","volume":"8","author":"Karbiener","year":"2011","journal-title":"RNA Biol."},{"key":"10.1016\/j.scr.2015.01.008_bb0140","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1073\/pnas.0307618100","article-title":"Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line","volume":"101","author":"Kondo","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scr.2015.01.008_bb0145","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrn2037","article-title":"The neuronal microRNA system","volume":"7","author":"Kosik","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.scr.2015.01.008_bb0150","doi-asserted-by":"crossref","first-page":"e10480","DOI":"10.1371\/journal.pone.0010480","article-title":"MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells","volume":"5","author":"Letzen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.scr.2015.01.008_bb0155","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4161\/cbt.12.6.16300","article-title":"MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme","volume":"12","author":"Li","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.scr.2015.01.008_bb0160","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1128\/MCB.05821-11","article-title":"MicroRNA-146a inhibits glioma development by targeting Notch1","volume":"31","author":"Mei","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scr.2015.01.008_bb0165","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijbiomac.2013.02.017","article-title":"Expression of microRNA-30c and its target genes in human osteoblastic cells by nano-bioglass ceramic-treatment","volume":"56","author":"Moorthi","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scr.2015.01.008_bb0170","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1038\/sj.onc.1209283","article-title":"Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues","volume":"25","author":"Murakami","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.scr.2015.01.008_bb0175","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00334878","article-title":"Invasion of experimental rat brain tumor: early morphological changes following microinjection of C6 glioma cells","volume":"86","author":"Nagano","year":"1993","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.scr.2015.01.008_bb0180","doi-asserted-by":"crossref","first-page":"10247","DOI":"10.1158\/0008-5472.CAN-06-2048","article-title":"Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas","volume":"66","author":"Pellegatta","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.scr.2015.01.008_bb0185","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/cns.12149","article-title":"MicroRNA-26a promotes tumor growth and angiogenesis in glioma by directly targeting prohibitin","volume":"9","author":"Qian","year":"2013","journal-title":"CNS Neurosci. Ther"},{"key":"10.1016\/j.scr.2015.01.008_bb0190","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.4049\/jimmunol.181.5.3167","article-title":"Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes","volume":"181","author":"Qin","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.scr.2015.01.008_bb0195","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF00172924","article-title":"Assessment of the experimental model of transplanted C6 glioblastoma in Wistar rats","volume":"7","author":"San-Galli","year":"1989","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.scr.2015.01.008_bb0200","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3171\/jns.1971.34.3.0335","article-title":"Morphological studies of rat brain tumors induced by N-nitrosomethylurea","volume":"34","author":"Schmidek","year":"1971","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.scr.2015.01.008_bb0205","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0898-6568(98)00069-2","article-title":"Activation of protein kinase A by dibutyryl cAMP treatment of NIH 3T3 cells inhibits proliferation but fails to induce Ser-133 phosphorylation and transcriptional activation of CREB","volume":"11","author":"Seternes","year":"1999","journal-title":"Cell. Signal."},{"key":"10.1016\/j.scr.2015.01.008_bb0210","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11626-008-9115-z","article-title":"Identification of cancer stem-like cells in the C6 glioma cell line and the limitation of current identification methods","volume":"44","author":"Shen","year":"2008","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.scr.2015.01.008_bb0215","doi-asserted-by":"crossref","first-page":"15441","DOI":"10.1074\/jbc.M311844200","article-title":"cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6","volume":"279","author":"Takanaga","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scr.2015.01.008_bb0220","doi-asserted-by":"crossref","first-page":"e49570","DOI":"10.1371\/journal.pone.0049570","article-title":"The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells","volume":"7","author":"Tan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.scr.2015.01.008_bb0225","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ijbiomac.2014.02.030","article-title":"MicroRNAs expression and their regulatory networks during mesenchymal stem cells differentiation toward osteoblasts","volume":"66","author":"Vimalraj","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scr.2015.01.008_bb0230","first-page":"142","article-title":"Microfluidic-based enzymatic on-chip labeling of miRNAs","volume":"25","author":"Vorwerk","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.scr.2015.01.008_bb0235","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2009.02.038","article-title":"MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells","volume":"137","author":"Xu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.scr.2015.01.008_bb0240","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/sj.bjc.6605142","article-title":"Isolation of tumour stem-like cells from benign tumours","volume":"101","author":"Xu","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.scr.2015.01.008_bb0245","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ccr.2006.01.025","article-title":"Unique microRNA molecular profiles in lung cancer diagnosis and prognosis","volume":"9","author":"Yanaihara","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.scr.2015.01.008_bb0250","first-page":"1747","article-title":"MicroRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4","volume":"25","author":"Yin","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.scr.2015.01.008_bb0255","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2008.02.010","article-title":"Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87","volume":"265","author":"Yu","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.scr.2015.01.008_bb0260","doi-asserted-by":"crossref","first-page":"21926","DOI":"10.1074\/jbc.M112.340398","article-title":"Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scr.2015.01.008_bb0265","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nsmb.1576","article-title":"A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination","volume":"16","author":"Zhao","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.scr.2015.01.008_bb0270","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.neuron.2010.02.018","article-title":"MicroRNA-mediated control of oligodendrocyte differentiation","volume":"65","author":"Zhao","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.scr.2015.01.008_bb0275","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1158\/0008-5472.CAN-06-3912","article-title":"Most C6 cells are cancer stem cells: evidence from clonal and population analyses","volume":"67","author":"Zheng","year":"2007","journal-title":"Cancer Res."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506115000240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506115000240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:28:50Z","timestamp":1761737330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506115000240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1873506115000240"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2015.01.008","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2015.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}