{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:36:00Z","timestamp":1760549760853},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006490","name":"DIR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006490","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.scr.2015.04.005","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T06:30:58Z","timestamp":1431066658000},"page":"42-53","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impaired function of bone marrow stromal cells in systemic mastocytosis"],"prefix":"10.1016","volume":"15","author":[{"given":"Krisztian","family":"Nemeth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqiang J.","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Sabatino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Stroncek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miklos","family":"Krepuska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela G.","family":"Robey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean D.","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Mezey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2015.04.005_bb0045","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.4158\/EP12062.CR","article-title":"Osteoporosis as the sole manifestation of systemic mastocytosis in a young man","volume":"18","author":"Abramowitz","year":"2012","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.scr.2015.04.005_bb0085","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1089\/hum.2010.136","article-title":"\u201cMesenchymal\u201d stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease","volume":"21","author":"Bianco","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.scr.2015.04.005_bb0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.iac.2013.09.001","article-title":"Mastocytosis","volume":"34","author":"Carter","year":"2014","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"10.1016\/j.scr.2015.04.005_bb0015","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jaci.2003.07.008","article-title":"Gene expression analysis in mastocytosis reveals a highly consistent profile with candidate molecular markers","volume":"112","author":"D'Ambrosio","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.scr.2015.04.005_bb0020","first-page":"126","article-title":"Mastocytosis presenting as a skeletal disorder","volume":"16","author":"Delsignore","year":"1996","journal-title":"Iowa Orthop. J."},{"key":"10.1016\/j.scr.2015.04.005_bb0030","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.hoc.2011.09.012","article-title":"Systemic mastocytosis","volume":"25","author":"George","year":"2011","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.scr.2015.04.005_bb0080","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0171-9335(99)80046-6","article-title":"Endoglin overexpression modulates cellular morphology, migration, and adhesion of mouse fibroblasts","volume":"78","author":"Guerrero-Esteo","year":"1999","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.scr.2015.04.005_bb0050","doi-asserted-by":"crossref","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","article-title":"Case-control cohort study of patients' perceptions of disability in mastocytosis","volume":"3","author":"Hermine","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.scr.2015.04.005_bb0060","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000101711","article-title":"Mastocytosis: state of the art","volume":"74","author":"Horny","year":"2007","journal-title":"Pathobiology"},{"key":"10.1016\/j.scr.2015.04.005_bb0125","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2249.2009.03933.x","article-title":"Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex","volume":"157","author":"King","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.scr.2015.04.005_bb0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jmoldx.2010.10.004","article-title":"Improved detection of the KIT D816V mutation in patients with systemic mastocytosis using a quantitative and highly sensitive real-time qPCR assay","volume":"13","author":"Kristensen","year":"2011","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.scr.2015.04.005_bb0095","doi-asserted-by":"crossref","first-page":"353878","DOI":"10.1155\/2011\/353878","article-title":"Paracrine molecules of mesenchymal stem cells for hematopoietic stem cell niche","volume":"2011","author":"Li","year":"2011","journal-title":"Bone Marrow Res."},{"key":"10.1016\/j.scr.2015.04.005_bb0055","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1182\/blood-2009-02-205237","article-title":"Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors","volume":"113","author":"Lim","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.scr.2015.04.005_bb0065","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1073\/pnas.96.4.1609","article-title":"Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis","volume":"96","author":"Longley","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scr.2015.04.005_bb0110","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jaci.2007.05.024","article-title":"KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1\/PDGFRA-associated chronic eosinophilic leukemia are distinct entities","volume":"120","author":"Maric","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.scr.2015.04.005_bb0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.it.2011.03.009","article-title":"Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells","volume":"32","author":"Nagasawa","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.scr.2015.04.005_bb0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000237541","article-title":"c-Kit mutation in a population of patients with mastocytosis","volume":"113","author":"Nagata","year":"1997","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.scr.2015.04.005_bb0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/stem.771","article-title":"Characterization and function of histamine receptors in human bone marrow stromal cells","volume":"30","author":"Nemeth","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.scr.2015.04.005_bb0040","article-title":"A practical guide to culturing mouse and human bone marrow stromal cells","volume":"102","author":"Nemeth","year":"2013"},{"key":"10.1016\/j.scr.2015.04.005_bb0070","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.hoc.2012.08.001","article-title":"Systemic mastocytosis: disease overview, pathogenesis, and treatment","volume":"26","author":"Pardanani","year":"2012","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.scr.2015.04.005_bb0120","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.scr.2013.07.005","article-title":"Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: molecular changes associated with BMSC senescence","volume":"11","author":"Ren","year":"2013","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.scr.2015.04.005_bb0025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.iac.2014.01.011","article-title":"Bone involvement and osteoporosis in mastocytosis","volume":"34","author":"Rossini","year":"2014","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"10.1016\/j.scr.2015.04.005_bb0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1479-5876-10-23","article-title":"The establishment of a bank of stored clinical bone marrow stromal cell products","volume":"10","author":"Sabatino","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.scr.2015.04.005_bb0090","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.scr.2015.04.005_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/117693510700300022","article-title":"Analysis of gene expression data using BRB-ArrayTools","volume":"3","author":"Simon","year":"2007","journal-title":"Cancer Informat."},{"key":"10.1016\/j.scr.2015.04.005_bb0105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12\u2013CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.scr.2015.04.005_bb0135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1365-2567.2003.01559.x","article-title":"Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene","volume":"108","author":"Sundstrom","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.scr.2015.04.005_bb0075","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1517\/14728220902915310","article-title":"Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies","volume":"13","author":"Takada","year":"2009","journal-title":"Expert Opin. Ther. Targets"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506115000471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506115000471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T19:15:01Z","timestamp":1566674101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506115000471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1873506115000471"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2015.04.005","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired function of bone marrow stromal cells in systemic mastocytosis","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2015.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}