{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:34:10Z","timestamp":1784759650302,"version":"3.55.0"},"reference-count":5,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.scr.2016.08.010","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T11:35:06Z","timestamp":1472038506000},"page":"289-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Generation of HEXA -deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient"],"prefix":"10.1016","volume":"17","author":[{"given":"Zhong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2016.08.010_bb0005","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/nprot.2012.130","article-title":"Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions","volume":"7","author":"Beers","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.scr.2016.08.010_bb0010","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.stemcr.2015.11.002","article-title":"Canonical MicroRNA activity facilitates but may Be dispensable for transcription factor-mediated reprogramming","volume":"5","author":"Liu","year":"2015","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.scr.2016.08.010_bb0015","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/stem.495","article-title":"Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette","volume":"28","author":"Somers","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.scr.2016.08.010_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157276","article-title":"The regulation of rRNA Gene transcription during directed differentiation of human embryonic stem cells","volume":"11","author":"Woolnough","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.scr.2016.08.010_bb0025","doi-asserted-by":"crossref","first-page":"15768","DOI":"10.1073\/pnas.1417518111","article-title":"A nontranscriptional role for Oct4 in the regulation of mitotic entry","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506116301106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506116301106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T21:51:44Z","timestamp":1536443504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506116301106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S1873506116301106"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2016.08.010","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2016.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}