{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:06:12Z","timestamp":1788897972996,"version":"build-2803163510"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004784","name":"Novartis Foundation for medical-biological research","doi-asserted-by":"publisher","award":["14C176"],"award-info":[{"award-number":["14C176"]}],"id":[{"id":"10.13039\/501100004784","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UZH Forschungskredit","award":["FK-15-023"],"award-info":[{"award-number":["FK-15-023"]}]},{"DOI":"10.13039\/501100012654","name":"Olga Mayenfisch Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012654","id-type":"DOI","asserted-by":"crossref"}]},{"name":"M\u00e4xi Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.scr.2018.01.019","type":"journal-article","created":{"date-parts":[[2018,1,28]],"date-time":"2018-01-28T22:59:07Z","timestamp":1517180347000},"page":"121-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":137,"special_numbering":"C","title":["Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-\u03b2 and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients"],"prefix":"10.1016","volume":"27","author":[{"given":"Julian H.","family":"Birnbaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton F.","family":"Gietl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Saake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"K\u00fcndig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger M.","family":"Nitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-3055","authenticated-orcid":false,"given":"Christian","family":"Tackenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2018.01.019_bb0005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nm0796-783","article-title":"Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules","volume":"2","author":"Alonso","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.scr.2018.01.019_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.160","article-title":"Calcium flux-independent NMDA receptor activity is required for Abeta oligomer-induced synaptic loss","volume":"6","author":"Birnbaum","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.scr.2018.01.019_bb0015","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0197-4580(01)00314-1","article-title":"Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease","volume":"23","author":"Bosetti","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.scr.2018.01.019_bb0020","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.stemcr.2017.02.006","article-title":"Phenotypic screening identifies modulators of amyloid precursor protein processing in human stem cell models of Alzheimer's disease","volume":"8","author":"Brownjohn","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.scr.2018.01.019_bb0025","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/378776a0","article-title":"Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro","volume":"378","author":"Busciglio","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.scr.2018.01.019_bb0030","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.scr.2018.01.019_bb0035","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1096\/fj.05-3735fje","article-title":"Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease","volume":"19","author":"Caspersen","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.scr.2018.01.019_bb0040","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1128\/MCB.7.8.2745","article-title":"High-efficiency transformation of mammalian cells by plasmid DNA","volume":"7","author":"Chen","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scr.2018.01.019_bb0045","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nmeth.1593","article-title":"Chemically defined conditions for human iPSC derivation and culture","volume":"8","author":"Chen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scr.2018.01.019_bb0050","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0055","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00023.2009","article-title":"Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process","volume":"90","author":"De Strooper","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.scr.2018.01.019_bb0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/mp.2016.112","article-title":"Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease","volume":"22","author":"Derungs","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.scr.2018.01.019_bb0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-9-3","article-title":"Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death","volume":"9","author":"Duan","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.scr.2018.01.019_bb0070","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tins.2013.03.002","article-title":"Why size matters - balancing mitochondrial dynamics in Alzheimer's disease","volume":"36","author":"DuBoff","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","article-title":"Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease","volume":"3","author":"Goedert","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.scr.2018.01.019_bb0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10522-015-9618-4","article-title":"Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease","volume":"17","author":"Grimm","year":"2016","journal-title":"Biogerontology"},{"key":"10.1016\/j.scr.2018.01.019_bb0085","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.neurobiolaging.2007.12.005","article-title":"Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice","volume":"30","author":"Hauptmann","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.scr.2018.01.019_bb0090","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer's disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.stem.2015.07.006","article-title":"Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules","volume":"17","author":"Hu","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.scr.2018.01.019_bb0100","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2016.12.044","article-title":"ApoE2, ApoE3, and ApoE4 differentially stimulate APP transcription and Abeta secretion","volume":"168","author":"Huang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.scr.2018.01.019_bb0105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.expneurol.2010.07.020","article-title":"The plasma membrane redox system is impaired by amyloid beta-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice","volume":"225","author":"Hyun","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.scr.2018.01.019_bb0110","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10821","article-title":"Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells","volume":"482","author":"Israel","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.scr.2018.01.019_bb0115","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","article-title":"Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies","volume":"53","author":"Kamat","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.scr.2018.01.019_bb0120","doi-asserted-by":"crossref","unstructured":"H. Kilpinen, A. Goncalves, A. Leha, V. Afzal, K. Alasoo, S. Ashford, S. Bala, D. Bensaddek, F.P. Casale, O.J. Culley, P. Danecek, A. Faulconbridge, P.W. Harrison, A. Kathuria, D. McCarthy, S.A. McCarthy, R. Meleckyte, Y. Memari, N. Moens, F. Soares, A. Mann, I. Streeter, C.A. Agu, A. Alderton, R. Nelson, S. Harper, M. Patel, A. White, S.R. Patel, L. Clarke, R. Halai, C.M. Kirton, A. Kolb-Kokocinski, P. Beales, E. Birney, D. Danovi, A.I. Lamond, W.H. Ouwehand, L. Vallier, F.M. Watt, R. Durbin, O. Stegle, D.J. Gaffney, Common genetic variation drives molecular heterogeneity in human iPSCs, Nature, 546 (2017) 370\u2013375.","DOI":"10.1038\/nature22403"},{"key":"10.1016\/j.scr.2018.01.019_bb0125","doi-asserted-by":"crossref","unstructured":"T. Kondo, M. Asai, K. Tsukita, Y. Kutoku, Y. Ohsawa, Y. Sunada, K. Imamura, N. Egawa, N. Yahata, K. Okita, K. Takahashi, I. Asaka, T. Aoi, A. Watanabe, K. Watanabe, C. Kadoya, R. Nakano, D. Watanabe, K. Maruyama, O. Hori, S. Hibino, T. Choshi, T. Nakahata, H. Hioki, T. Kaneko, M. Naitoh, K. Yoshikawa, S. Yamawaki, S. Suzuki, R. Hata, S. Ueno, T. Seki, K. Kobayashi, T. Toda, K. Murakami, K. Irie, W.L. Klein, H. Mori, T. Asada, R. Takahashi, N. Iwata, S. Yamanaka, H. Inoue, Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular A\u03b2 and differential drug responsiveness., Cell Stem Cell, 12 (2013) 487\u2013496.","DOI":"10.1016\/j.stem.2013.01.009"},{"key":"10.1016\/j.scr.2018.01.019_bb0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2014.12.019","article-title":"Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.scr.2018.01.019_bb0135","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0140","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/hmg\/dds072","article-title":"Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.scr.2018.01.019_bb0145","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuron.2005.06.030","article-title":"Abeta42 is essential for parenchymal and vascular amyloid deposition in mice","volume":"47","author":"McGowan","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.scr.2018.01.019_bb0150","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.scr.2018.01.019_bb0155","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ana.410360510","article-title":"Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease","volume":"36","author":"Mecocci","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.scr.2018.01.019_bb0160","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00401-016-1560-2","article-title":"Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy","volume":"131","author":"Merlini","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.scr.2018.01.019_bb0165","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.stemcr.2013.10.011","article-title":"APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based \u03b3-secretase modulation","volume":"1","author":"Mertens","year":"2013","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.scr.2018.01.019_bb0170","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.celrep.2015.03.068","article-title":"APP metabolism regulates tau proteostasis in human cerebral cortex neurons","volume":"11","author":"Moore","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.scr.2018.01.019_bb0175","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s004010050997","article-title":"Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology","volume":"97","author":"Nagy","year":"1999","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.scr.2018.01.019_bb0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000452256","article-title":"From common to rare variants: the genetic component of Alzheimer disease","volume":"81","author":"Nicolas","year":"2016","journal-title":"Hum. Hered."},{"key":"10.1016\/j.scr.2018.01.019_bb0185","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scr.2018.01.019_bb0190","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2017.05.037","article-title":"TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss","volume":"95","author":"Paolicelli","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.scr.2018.01.019_bb0200","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00401-008-0370-6","article-title":"Dystrophic neurites of senile plaques in Alzheimer's disease are deficient in cytochrome c oxidase","volume":"116","author":"Perez-Gracia","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.scr.2018.01.019_bb0205","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear communication in homeostasis and stress","volume":"17","author":"Quiros","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scr.2018.01.019_bb0210","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/hmg\/ddh140","article-title":"Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease","volume":"13","author":"Reddy","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.scr.2018.01.019_bb0215","doi-asserted-by":"crossref","first-page":"20057","DOI":"10.1073\/pnas.0905529106","article-title":"Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice","volume":"106","author":"Rhein","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scr.2018.01.019_bb0220","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scr.2018.01.019_bb0225","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single App knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0230","doi-asserted-by":"crossref","first-page":"9933","DOI":"10.1523\/JNEUROSCI.1907-16.2016","article-title":"Calpain activation in Alzheimer's model mice is an artifact of APP and presenilin overexpression","volume":"36","author":"Saito","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0235","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exger.2006.10.003","article-title":"Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice","volume":"42","author":"Sanz","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.scr.2018.01.019_bb0240","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0304-3940(02)00210-0","article-title":"Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and down syndrome","volume":"324","author":"Shim","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.scr.2018.01.019_bb0245","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1093\/hmg\/ddv246","article-title":"Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10+16 splice-site mutation in MAPT","volume":"24","author":"Sposito","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.scr.2018.01.019_bb0250","doi-asserted-by":"crossref","first-page":"14439","DOI":"10.1523\/JNEUROSCI.3590-09.2009","article-title":"Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau","volume":"29","author":"Tackenberg","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.129","article-title":"NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss","volume":"4","author":"Tackenberg","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.scr.2018.01.019_bb0260","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1523\/JNEUROSCI.23-16-06586.2003","article-title":"Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis","volume":"23","author":"Takahashi","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0265","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.scr.2018.01.019_bb0270","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.scr.2018.01.019_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032737","article-title":"Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease","volume":"7","author":"Trushina","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.scr.2018.01.019_bb0280","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.scr.2018.01.019_bb0285","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer's disease","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2018.01.019_bb0290","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1474-4422(16)00062-4","article-title":"Defeating Alzheimer's disease and other dementias: a priority for European science and society","volume":"15","author":"Winblad","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.scr.2018.01.019_bb0295","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.celrep.2013.10.018","article-title":"The Presenilin-1 \u0394E9 mutation results in reduced \u03b3-secretase activity, but not total loss of PS1 function, in isogenic human stem cells","volume":"5","author":"Woodruff","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.scr.2018.01.019_bb0300","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1093\/hmg\/ddr394","article-title":"Modeling familial Alzheimer's disease with induced pluripotent stem cells","volume":"20","author":"Yagi","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.scr.2018.01.019_bb0305","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease","volume":"106","author":"Yao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scr.2018.01.019_bb0310","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuron.2013.05.029","article-title":"Rapid single-step induction of functional neurons from human pluripotent stem cells","volume":"78","author":"Zhang","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.scr.2018.01.019_bb0315","doi-asserted-by":"crossref","first-page":"316523","DOI":"10.1155\/2013\/316523","article-title":"Oxidative stress and the pathogenesis of Alzheimer's disease","volume":"2013","author":"Zhao","year":"2013","journal-title":"Oxidative Med. Cell. Longev."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506118300254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506118300254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T22:35:10Z","timestamp":1589841310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506118300254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":63,"alternative-id":["S1873506118300254"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2018.01.019","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-\u03b2 and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2018.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}