{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:13:41Z","timestamp":1781111621192,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1029231"],"award-info":[{"award-number":["1029231"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK062882"],"award-info":[{"award-number":["R01DK062882"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.scr.2018.06.001","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T14:22:04Z","timestamp":1529590924000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["GSK3 inhibition, but not epigenetic remodeling, mediates efficient derivation of germline embryonic stem cells from nonobese diabetic mice"],"prefix":"10.1016","volume":"31","author":[{"given":"Jun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle P.","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira K.","family":"O'Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Brodnicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2018.06.001_bb0005","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1146\/annurev.immunol.23.021704.115643","article-title":"The NOD mouse: a model of immune dysregulation","volume":"23","author":"Anderson","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.scr.2018.06.001_bb0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2337\/diabetes.52.1.205","article-title":"The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome","volume":"52","author":"Brook","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.scr.2018.06.001_bb0015","doi-asserted-by":"crossref","first-page":"859","DOI":"10.4049\/jimmunol.0903149","article-title":"An NZW-derived interval on chromosome 7 moderates sialadenitis, but not insulitis in congenic nonobese diabetic mice","volume":"184","author":"Burt","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.scr.2018.06.001_bb0020","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1128\/MCB.25.12.4881-4891.2005","article-title":"Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein","volume":"25","author":"Carlone","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scr.2018.06.001_bb0025","doi-asserted-by":"crossref","first-page":"702","DOI":"10.2144\/05385BM05","article-title":"Simplex PCR assay for sex determination in mice","volume":"38","author":"Clapcote","year":"2005","journal-title":"BioTechniques"},{"key":"10.1016\/j.scr.2018.06.001_bb0030","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1089\/scd.2011.0427","article-title":"Optimization of protocols for derivation of mouse embryonic stem cell lines from refractory strains, including the non obese diabetic mouse","volume":"21","author":"Davies","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.scr.2018.06.001_bb0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00281-010-0204-1","article-title":"Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease","volume":"33","author":"Driver","year":"2011","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.scr.2018.06.001_bb0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fgene.2016.00043","article-title":"Gene targeting using homologous recombination in embryonic stem cells: the future for behavior genetics?","volume":"7","author":"Gerlai","year":"2016","journal-title":"Front. Genet."},{"key":"10.1016\/j.scr.2018.06.001_bb0045","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.stem.2009.04.015","article-title":"Metastable pluripotent states in NOD-mouse-derived ESCs","volume":"4","author":"Hanna","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.scr.2018.06.001_bb0050","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt1418","article-title":"Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds","volume":"26","author":"Huangfu","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.scr.2018.06.001_bb0055","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2337\/db15-1175","article-title":"A SNP in the immunoregulatory molecule CTLA-4 controls mRNA splicing in vivo but does not Alter diabetes susceptibility in the NOD mouse","volume":"65","author":"Jakubczik","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.scr.2018.06.001_bb0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/clo.2008.0053","article-title":"Improvement of embryonic stem cell line derivation efficiency with novel medium, glucose concentration, and epigenetic modifications","volume":"11","author":"Kim","year":"2009","journal-title":"Cloning Stem Cells"},{"key":"10.1016\/j.scr.2018.06.001_bb0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1262\/jrd.18098","article-title":"Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer","volume":"53","author":"Kishigami","year":"2007","journal-title":"J. Reprod. Develop."},{"key":"10.1016\/j.scr.2018.06.001_bb0070","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/dev.02880","article-title":"FGF stimulation of the Erk1\/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment","volume":"134","author":"Kunath","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.scr.2018.06.001_bb0075","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.2337\/db10-1540","article-title":"Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts","volume":"60","author":"Liu","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.scr.2018.06.001_bb0080","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3727\/096368910X514305","article-title":"Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation","volume":"20","author":"Liu","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.scr.2018.06.001_bb0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature07056","article-title":"Dissecting direct reprogramming through integrative genomic analysis","volume":"454","author":"Mikkelsen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.scr.2018.06.001_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056738","article-title":"The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice","volume":"8","author":"Morgan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.scr.2018.06.001_bb0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-5793(99)00801-7","article-title":"Establishment of an embryonic stem (ES) cell line derived from a non- obese diabetic (NOD) mouse: in vivo differentiation into lymphocytes and potential for germ line transmission","volume":"455","author":"Nagafuchi","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.scr.2018.06.001_bb0100","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm.1996","article-title":"Validated germline-competent embryonic stem cell lines from nonobese diabetic mice","volume":"15","author":"Nichols","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.scr.2018.06.001_bb0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbrc.2006.02.127","article-title":"Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells","volume":"343","author":"Ogawa","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scr.2018.06.001_bb0110","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1095\/biolreprod.109.079368","article-title":"Male germline and embryonic stem cell lines from NOD mice: efficient derivation of GS cells from a nonpermissive strain for ES cell derivation","volume":"81","author":"Ohta","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.scr.2018.06.001_bb0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jaut.2015.08.019","article-title":"The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes","volume":"66","author":"Pearson","year":"2016","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.scr.2018.06.001_bb0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0065-2776(08)00806-7","article-title":"Gene-gene interactions in the NOD mouse model of type 1 diabetes","volume":"100","author":"Ridgway","year":"2008","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.scr.2018.06.001_bb0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm979","article-title":"Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor","volume":"10","author":"Sato","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.scr.2018.06.001_bb0130","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1634\/stemcells.2007-0086","article-title":"Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase-3","volume":"25","author":"Umehara","year":"2007","journal-title":"Stem Cells"},{"issue":"Suppl","key":"10.1016\/j.scr.2018.06.001_bb0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2005.09.009","article-title":"Type 1 diabetes genes and pathways shared by humans and NOD mice","volume":"25","author":"Wicker","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.scr.2018.06.001_bb0140","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1101\/gad.1424006","article-title":"Wnt signaling: is the party in the nucleus?","volume":"20","author":"Willert","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.scr.2018.06.001_bb0145","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature06968","article-title":"The ground state of embryonic stem cell self-renewal","volume":"453","author":"Ying","year":"2008","journal-title":"Nature"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506118301491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506118301491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:30:25Z","timestamp":1761737425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506118301491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":29,"alternative-id":["S1873506118301491"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2018.06.001","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GSK3 inhibition, but not epigenetic remodeling, mediates efficient derivation of germline embryonic stem cells from nonobese diabetic mice","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2018.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}