{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:17:55Z","timestamp":1787314675353,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008235","name":"School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.scr.2018.10.006","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T23:19:25Z","timestamp":1538608765000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["High fat diet activates adult mouse lung stem cells and accelerates several aging-induced effects"],"prefix":"10.1016","volume":"33","author":[{"given":"Ahmed E.","family":"Hegab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0649-7882","authenticated-orcid":false,"given":"Mari","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Y.","family":"Meligy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-1664","authenticated-orcid":false,"given":"Makoto","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Betsuyaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.scr.2018.10.006_bb0005","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/j.febslet.2007.06.075","article-title":"Chronic lung inflammation in aging mice","volume":"581","author":"Aoshiba","year":"2007","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.scr.2018.10.006_bb0010","doi-asserted-by":"crossref","first-page":"28","DOI":"10.20463\/jenb.2016.06.20.2.4","article-title":"Exercise and dietary change ameliorate high fat diet induced obesity and insulin resistance via mTOR signaling pathway","volume":"20","author":"Bae","year":"2016","journal-title":"J. Exerc. Nutr. Biochem."},{"issue":"7592","key":"10.1016\/j.scr.2018.10.006_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.scr.2018.10.006_bb0020","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1158\/1940-6207.CAPR-12-0467","article-title":"Caloric restriction reverses obesity-induced mammary gland inflammation in mice","volume":"6","author":"Bhardwaj","year":"2013","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.scr.2018.10.006_bb0025","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.29.1_supplement.1015.3","article-title":"Mitochondria homeostasis plays a key role in the age-related susceptibility to lung epithelial injury and fibrosis","volume":"29","author":"Bueno","year":"2015","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.scr.2018.10.006_bb0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1189\/jlb.4A0214-093RR","article-title":"Characterization of lung inflammation and its impact on macrophage function in aging","volume":"96","author":"Canan","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.scr.2018.10.006_bb0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.metabol.2017.09.005","article-title":"Carnitine induces autophagy and restores high-fat diet-induced mitochondrial dysfunction","volume":"78","author":"Choi","year":"2018","journal-title":"Metabolism"},{"issue":"11","key":"10.1016\/j.scr.2018.10.006_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112406","article-title":"Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity","volume":"9","author":"Clark-Knowles","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.scr.2018.10.006_bb0045","doi-asserted-by":"crossref","first-page":"256","DOI":"10.18632\/aging.100738","article-title":"High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL\/6j mice","volume":"7","author":"van der Heijden","year":"2015","journal-title":"Aging (Albany NY)"},{"issue":"7534","key":"10.1016\/j.scr.2018.10.006_bb0050","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature14190","article-title":"Nutrient sensing mechanisms and pathways","volume":"517","author":"Efeyan","year":"2015","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.scr.2018.10.006_bb0055","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1513\/pats.200803-025HR","article-title":"Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function","volume":"5","author":"Franks","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.scr.2018.10.006_bb0060","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1465-9921-8-47","article-title":"Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation","volume":"8","author":"Gereke","year":"2007","journal-title":"Respir. Res."},{"key":"10.1016\/j.scr.2018.10.006_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-0348-0837-8_1","article-title":"The role of inflammation in lung cancer","volume":"816","author":"Gomes","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.scr.2018.10.006_bb0070","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00001648-199207000-00004","article-title":"High-fat foods and the risk of lung cancer","volume":"3","author":"Goodman","year":"1992","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.scr.2018.10.006_bb0075","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-016-0666-8","article-title":"High-fat diet feeding differentially affects the development of inflammation in the central nervous system","volume":"13","author":"Guillemot-Legris","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.scr.2018.10.006_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.scr.2015.05.005","article-title":"Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior","volume":"15","author":"Hegab","year":"2015","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.scr.2018.10.006_bb0085","series-title":"Stem Cells in the Lung: Development, Repair and Regeneration","first-page":"97","article-title":"Stem and progenitor cells of the trachea and proximal airways","author":"Hegab","year":"2015"},{"key":"10.1016\/j.scr.2018.10.006_bb0090","series-title":"Calorie Restriction Enhances Adult Mouse Lung Stem Cells Function and Reverses Several Aging-Induced Changes","author":"Hegab","year":"2018"},{"issue":"3","key":"10.1016\/j.scr.2018.10.006_bb0095","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1079\/BJN20051711","article-title":"Effects of fatty acids on skeletal muscle cell differentiation in vitro","volume":"95","author":"Hurley","year":"2006","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.scr.2018.10.006_bb0100","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.redox.2016.01.009","article-title":"Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance","volume":"8","author":"Kakimoto","year":"2016","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.scr.2018.10.006_bb0105","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s00380-009-1182-x","article-title":"Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl\/6 mice","volume":"25","author":"Ketonen","year":"2010","journal-title":"Heart Vessel."},{"issue":"10","key":"10.1016\/j.scr.2018.10.006_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047713","article-title":"High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in mice via the TLR4 Signaling Pathway","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.scr.2018.10.006_bb0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12931-017-0554-5","article-title":"Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung","volume":"18","author":"Kuroda","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.scr.2018.10.006_bb0120","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1038\/ctg.2013.11","article-title":"The effect of high-fat diet-induced pathophysiological changes in the gut on obesity: what should be the ideal treatment?","volume":"4","author":"Lee","year":"2013","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"1","key":"10.1016\/j.scr.2018.10.006_bb0125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/acel.12277","article-title":"Effects of nutritional components on aging","volume":"14","author":"Lee","year":"2015","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.scr.2018.10.006_bb0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1083\/jcb.201010131","article-title":"Manifestations and mechanisms of stem cell aging","volume":"193","author":"Liu","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.scr.2018.10.006_bb0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbacli.2015.11.003","article-title":"The mTOR pathway in obesity driven gastrointestinal cancers: potential targets and clinical trials","volume":"5","author":"Malley","year":"2015","journal-title":"BBA Clin."},{"issue":"21","key":"10.1016\/j.scr.2018.10.006_bb0140","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2174\/1568026615666150610125715","article-title":"Longevity pathways (mTOR, SIRT, insulin\/IGF-1) as key modulatory targets on aging and neurodegeneration","volume":"15","author":"Mazucanti","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"issue":"3","key":"10.1016\/j.scr.2018.10.006_bb0145","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1183\/09031936.00186914","article-title":"Hallmarks of the ageing lung","volume":"45","author":"Meiners","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.scr.2018.10.006_bb0150","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.28.1_supplement.40.4","article-title":"Effects of prolonged calorie restriction on inflammation and immune function: a randomized controlled trial in non-obese humans","volume":"28","author":"Meydani","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.scr.2018.10.006_bb0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s41232-016-0020-7","article-title":"Inflammatory responses in the initiation of lung repair and regeneration: their role in stimulating lung resident stem cells","volume":"36","author":"Mitsuhiro Yamada","year":"2016","journal-title":"Inflamm. Regen."},{"issue":"6","key":"10.1016\/j.scr.2018.10.006_bb0160","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/mi.2014.33","article-title":"Foxp3+ regulatory T cells promote lung epithelial proliferation","volume":"7","author":"Mock","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.scr.2018.10.006_bb0165","first-page":"1","article-title":"Inflammatory mechanisms in the lung","volume":"2","author":"Moldoveanu","year":"2009","journal-title":"J. Inflamm. Res."},{"issue":"1","key":"10.1016\/j.scr.2018.10.006_bb0170","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2046-2395-2-10","article-title":"High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice","volume":"2","author":"Muller","year":"2013","journal-title":"Longev. Healthspan."},{"issue":"2","key":"10.1016\/j.scr.2018.10.006_bb0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tem.2010.11.002","article-title":"High fat diet induced obesity and nutrient sensing tor signaling","volume":"22","author":"Oldham","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"issue":"28","key":"10.1016\/j.scr.2018.10.006_bb0180","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1073\/pnas.0802917105","article-title":"Sirt1 protects against high-fat diet-induced metabolic damage","volume":"105","author":"Pfluger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scr.2018.10.006_bb0185","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/B978-0-12-381300-8.00007-1","article-title":"Bronchus-associated lymphoid tissue (BALT) structure and function","volume":"107","author":"Randall","year":"2010","journal-title":"Adv. Immunol."},{"issue":"11","key":"10.1016\/j.scr.2018.10.006_bb0190","doi-asserted-by":"crossref","first-page":"L962","DOI":"10.1152\/ajplung.00073.2014","article-title":"Mitochondria in lung biology and pathology: more than just a powerhouse","volume":"306","author":"Schumacker","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.scr.2018.10.006_bb0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yjmcc.2014.07.018","article-title":"High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II","volume":"78","author":"Sverdlov","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.scr.2018.10.006_bb0200","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.kint.2016.06.013","article-title":"Protection of mitochondria prevents high-fat diet\u2013induced glomerulopathy and proximal tubular injury","volume":"90","author":"Szeto","year":"2016","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.scr.2018.10.006_bb0205","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.jnutbio.2015.07.029","article-title":"Sirt1 mediates the effects of a short-term high-fat diet on the heart","volume":"26","author":"Villarroya","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.scr.2018.10.006_bb0210","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1038\/nutd.2013.4","article-title":"The age of attaining highest body weight correlates with lifespan in a genetically obese mouse model","volume":"3","author":"Wagener","year":"2013","journal-title":"Nutr. Diabetes"},{"issue":"3","key":"10.1016\/j.scr.2018.10.006_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093496","article-title":"Age-related changes in the cellular composition and epithelial organization of the mouse trachea","volume":"9","author":"Wansleeben","year":"2014","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.scr.2018.10.006_bb0220","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1096\/fasebj.11.13.9367355","article-title":"Atherosclerosis, autoimmunity, and vascular-associated lymphoid tissue","volume":"11","author":"Wick","year":"1997","journal-title":"FASEB J."},{"key":"10.1016\/j.scr.2018.10.006_bb0225","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12931-014-0116-z","article-title":"Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia","volume":"15","author":"Yin","year":"2014","journal-title":"Respir. Res."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506118302459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506118302459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T02:45:23Z","timestamp":1662173123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506118302459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":45,"alternative-id":["S1873506118302459"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2018.10.006","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High fat diet activates adult mouse lung stem cells and accelerates several aging-induced effects","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2018.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}