{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:13:39Z","timestamp":1791576819989,"version":"4.3.4"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["15-13443Y"],"award-info":[{"award-number":["15-13443Y"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["17-05466S"],"award-info":[{"award-number":["17-05466S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014417","name":"Pa\u0144stwowy Instytut Weterynaryjny - Pa\u0144stwowy Instytut Badawczy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008738","name":"Jeanssons Stiftelser","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006435","name":"Central European Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008796","name":"Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010653","name":"Masarykova Univerzita","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000495"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000495"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013856","name":"Neuron Nada\u010dn\u00ed Fond Na Podporu V\u011bdy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.scr.2020.101770","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T11:37:15Z","timestamp":1585395435000},"page":"101770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Hypoxia\/Hif1\u03b1 prevents premature neuronal differentiation of neural stem cells through the activation of Hes1"],"prefix":"10.1016","volume":"45","author":[{"given":"Josef","family":"Ve\u010de\u0159a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159ina","family":"Proch\u00e1zkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"\u0160umberov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"P\u00e1nsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-723X","authenticated-orcid":false,"given":"Hana","family":"Paculov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina Kohutkov\u00e1","family":"L\u00e1nov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Ma\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1\u0161a","family":"Boha\u010diakov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Rachel","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Pachern\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2020.101770_bib0001","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s10517-012-1892-4","article-title":"Effect of hypoxia on neural induction in colonies of human parthenogenetic stem cells","volume":"154","author":"Abramihina","year":"2012","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.scr.2020.101770_bib0002","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1242\/dev.063610","article-title":"Notch signaling: simplicity in design, versatility in function","volume":"138","author":"Andersson","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.scr.2020.101770_bib0003","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000090751","article-title":"Notch signaling is required to maintain all neural stem cell populations - irrespective of spatial or temporal niche","volume":"28","author":"Alexson","year":"2006","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.scr.2020.101770_bib0004","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/35067582","article-title":"A unified hypothesis on the lineage of neural stem cells","volume":"2","author":"Alvarez-Buylla","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.scr.2020.101770_bib0005","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nm.2167","article-title":"Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos","volume":"16","author":"Beronja","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.scr.2020.101770_bib0006","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1179\/1743132814Y.0000000338","article-title":"Time-sensitive effects of hypoxia on differentiation of neural stem cells derived from mouse embryonic stem cells in vitro","volume":"36","author":"Binh","year":"2014","journal-title":"Neurol. Res."},{"key":"10.1016\/j.scr.2020.101770_bib0007","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1101\/gad.1145503","article-title":"Oxygen sensing in the hypoxic response path- way: regulation of the hypoxia-inducible transcription factor","volume":"17","author":"Bruick","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.scr.2020.101770_bib0008","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1074\/jbc.M010144200","article-title":"Regulation of glut1 mRNA by hypoxia-inducible factor-1: interaction between H-ras and hypoxia","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scr.2020.101770_bib0009","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1371\/journal.pmed.0030047","article-title":"Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers","volume":"3","author":"Chi","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.scr.2020.101770_bib0010","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1242\/dev.124.6.1139","article-title":"Conservation of the Notch signalling pathway in mammalian neurogenesis","volume":"124","author":"de la Pompa","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.scr.2020.101770_bib0011","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1073\/pnas.81.22.7233","article-title":"Identification and characterization of the glucose transporter of the blood-brain barrier by cytochalasin B binding and immunological reactivity","volume":"81","author":"Dick","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.scr.2020.101770_bib0012","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1073\/pnas.0501283102","article-title":"Low O2 tensions and the prevention of differentiation of hES cells","volume":"102","author":"Ezashi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.scr.2020.101770_bib0013","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","article-title":"The cell biology of neurogenesis","volume":"6","author":"G\u00f6tz","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0014","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2005.09.010","article-title":"Hypoxia requires notch signaling to maintain the undifferentiated cell state","volume":"9","author":"Gustafsson","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.scr.2020.101770_bib0015","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1242\/dev.01436","article-title":"Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation","volume":"131","author":"Hatakeyama","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.scr.2020.101770_bib0016","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1677\/joe.1.05599","article-title":"Induction of glucose transporter 1 expression through hypoxia-inducible factor 1\u03b1 under hypoxic conditions in trophoblast-derived cells","volume":"183","author":"Hayashi","year":"2004","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.scr.2020.101770_bib0017","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1101\/gad.975202","article-title":"Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells","author":"Hitoshi","year":"2002","journal-title":"Gene. Dev."},{"key":"10.1016\/j.scr.2020.101770_bib0018","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1101\/gad.1208404","article-title":"Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling","author":"Hitoshi","year":"2004","journal-title":"Gene. Dev."},{"key":"10.1016\/j.scr.2020.101770_bib0019","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nn.2875","article-title":"Mammalian GCM genes induce HES5 expression by active DNA demethylation and induce neural stem cells","volume":"14","author":"Hitoshi","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.scr.2020.101770_bib0020","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/j.1460-2075.1994.tb06448.x","article-title":"Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system","volume":"13","author":"Ishibashi","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.scr.2020.101770_bib0021","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1101\/gad.9.24.3136","article-title":"Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects","volume":"9","author":"Ishibashi","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.scr.2020.101770_bib0022","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1242\/dev.000786","article-title":"The HES gene family: repressors and oscillators that orchestrate embryogenesis","volume":"134","author":"Kageyama","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.scr.2020.101770_bib0023","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/ncb1534","article-title":"Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia","volume":"9","author":"Kaidi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0024","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1242\/dev.022616","article-title":"Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis","volume":"135","author":"Kawaguchi","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.scr.2020.101770_bib0025","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1101\/gad.1823109","article-title":"The cyclic gene HES1 contributes to diverse differentiation responses of embryonic stem cells","volume":"23","author":"Kobayashi","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.scr.2020.101770_bib0026","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2443.2010.01413.x","article-title":"Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling","volume":"15","author":"Kobayashi","year":"2010","journal-title":"Genes to Cells"},{"key":"10.1016\/j.scr.2020.101770_bib0027","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1242\/dev.120.9.2385","article-title":"The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD","volume":"120","author":"Kopan","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.scr.2020.101770_bib0028","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/1097-0177(20010201)220:2<175::AID-DVDY1101>3.0.CO;2-F","article-title":"Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development","volume":"220","author":"Lee","year":"2001","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.scr.2020.101770_bib0029","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/emmm.201101107","article-title":"Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF","volume":"4","author":"Lee","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.scr.2020.101770_bib0030","article-title":"Tumor microenvironment (Chapter 10)","volume":"899","author":"Leek","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0031","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(90)90662-X","article-title":"CNS stem cells express a new class of intermediate filament protein","volume":"60","author":"Lendahl","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.scr.2020.101770_bib0032","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1523\/JNEUROSCI.18-19-07768.1998","article-title":"Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbilis","volume":"18","author":"Liu","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2020.101770_bib0033","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1371\/journal.pbio.0040121","article-title":"Notch promotes neural lineage entry by pluripotent embryonic stem cells","volume":"4","author":"Lowell","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1016\/j.scr.2020.101770_bib0034","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ncb2102","article-title":"O2 regulates stem cells through Wnt\/\u03b2-catenin signalling","volume":"12","author":"Mazumdar","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.scr.2020.101770_bib0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/386403a0","article-title":"Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT","volume":"386","author":"Maltepe","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.scr.2020.101770_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0080280","article-title":"Effect of oxygen on cardiac differentiation in mouse iPS cells: role of hypoxia inducible factor-1 and Wnt\/beta-catenin signaling","volume":"8","author":"Medley","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.scr.2020.101770_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.11621","article-title":"Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin\/\u03b1-albumin","volume":"5","author":"Mihara","year":"2016","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.scr.2020.101770_bib0038","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1210\/endo-83-4-691","article-title":"Measurement of intra-uterine oxygen tension in the rat and its regulation by ovarian steroid hormones","volume":"83","author":"Mitchell","year":"1968","journal-title":"Endocrinology"},{"key":"10.1016\/j.scr.2020.101770_bib0039","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1523\/JNEUROSCI.20-19-07370.2000","article-title":"Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells","volume":"20","author":"Morrison","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2020.101770_bib0040","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1523\/JNEUROSCI.20-01-00283.2000","article-title":"The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells","volume":"20","author":"Nakamura","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2020.101770_bib0041","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/01.RES.0000226497.52052.2a","article-title":"Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling","volume":"98","author":"Nemir","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.scr.2020.101770_bib0042","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/emboj\/18.8.2196","article-title":"Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation","volume":"18","author":"Ohtsuka","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.scr.2020.101770_bib0043","doi-asserted-by":"crossref","first-page":"30467","DOI":"10.1074\/jbc.M102420200","article-title":"Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain","volume":"276","author":"Ohtsuka","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scr.2020.101770_bib0044","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2217\/17460751.1.1.71","article-title":"Oxygen, epigenetics and stem cell fate","volume":"1","author":"Okazaki","year":"2006","journal-title":"Regen. Med."},{"issue":"5","key":"10.1016\/j.scr.2020.101770_bib0045","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0015-0282(16)60688-X","article-title":"The toxic effect of short exposures to the atmospheric oxygen concentration on early mouse embryonic development","volume":"51","author":"Pabon","year":"1989","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.scr.2020.101770_bib0046","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/toxsci\/kft110","article-title":"Aryl hydrocarbon receptor negatively regulates expression of the plakoglobin gene (Jup)","volume":"134","author":"Proch\u00e1zkov\u00e1","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scr.2020.101770_bib0047","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10571-010-9561-5","article-title":"Continuous expression of HIF-1\u03b1 in neural stem\/progenitor cells","volume":"31","author":"Roitbak","year":"2011","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.scr.2020.101770_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1996.0090","article-title":"Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell","volume":"175","author":"Reynolds","year":"1996","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.scr.2020.101770_bib0049","first-page":"283","article-title":"Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy","volume":"80","author":"Rodesch","year":"1992","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.scr.2020.101770_bib0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jez.1402060108","article-title":"The effect of oxygen on the development of preimplantation mouse embryos in vitro","volume":"206","author":"Quinn","year":"1978","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.scr.2020.101770_bib0051","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1101\/gad.6.12b.2620","article-title":"Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split","volume":"6","author":"Sasai","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/j.scr.2020.101770_bib0052","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-4547(19970215)47:4<405::AID-JNR6>3.0.CO;2-I","article-title":"Retinoic acid induced neural differentiation in a neuroectodermal cell line immortalized by p53 deficiency","volume":"415","author":"Schlett","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.scr.2020.101770_bib0053","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","article-title":"Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1","volume":"269","author":"Semenza","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scr.2020.101770_bib0054","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.cellbio.15.1.551","article-title":"Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1","volume":"15","author":"Semenza","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0891-0618(03)00067-X","article-title":"Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells","volume":"26","author":"Storch","year":"2003","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.scr.2020.101770_bib0056","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1523\/JNEUROSCI.20-19-07377.2000","article-title":"Enhanced proliferation, survival and dopaminergic differentiation of CNS precursors in lowered oxygen","volume":"20","author":"Studer","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scr.2020.101770_bib0057","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-8993(99)01411-0","article-title":"Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice","volume":"831","author":"Takagi","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.scr.2020.101770_bib0058","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1128\/MCB.23.19.6739-6749.2003","article-title":"Defective brain development in mice lacking the HIF-1 gene in neural cells","volume":"23","author":"Tomita","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0059","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(01)00263-X","article-title":"Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism","volume":"30","author":"Tropepe","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.scr.2020.101770_bib0060","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/dbio.1998.9192","article-title":"Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon","volume":"188","author":"Tropepe","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0061","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-213X-8-89","article-title":"Generation of diverse neuronal subtypes in cloned populations of stem-like cells","volume":"8","author":"Varga","year":"2008","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8715798","article-title":"Neural differentiation is inhibited through Hif1\u03b1\/\u03b2-catenin signaling in embryoid bodies","volume":"2017","author":"Ve\u010de\u0159a","year":"2017","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.scr.2020.101770_bib0063","first-page":"609","article-title":"Oxygen(es) and the hypoxia-inducible factor-1","volume":"378","author":"Wenger","year":"1997","journal-title":"Biol. Chem."},{"key":"10.1016\/j.scr.2020.101770_bib0064","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-59745-249-6_2","article-title":"Isolation and application of bioactive wnt proteins","volume":"468","author":"Willert","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.scr.2020.101770_bib0065","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/carcin\/bgt027","article-title":"Wnt\/\u03b2-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1\u03b1 signaling","volume":"34","author":"Zhang","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.scr.2020.101770_bib0066","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1089\/scd.2013.0278","article-title":"Dual functions of hypoxia-inducible factor 1 alpha for the commitment of mouse embryonic stem cells toward a neural lineage","volume":"23","author":"Zhao","year":"2014","journal-title":"Stem Cells Dev"},{"issue":"6","key":"10.1016\/j.scr.2020.101770_bib0067","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/ana.22318","article-title":"Glut1\/SLC2A1 is crucial for the development of the blood-brain barrier in vivo","volume":"68","author":"Zheng","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.scr.2020.101770_bib0068","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yexcr.2017.06.006","article-title":"A notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells","volume":"358","author":"Zheng","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.scr.2020.101770_bib0069","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1385\/MN:31:1-3:231","article-title":"Effects of hypoxia on the proliferation and differentiation of NSCs","volume":"31","author":"Zhu","year":"2005","journal-title":"Mol. Neurobiol."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187350612030074X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187350612030074X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:32:25Z","timestamp":1761737545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187350612030074X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":69,"alternative-id":["S187350612030074X"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2020.101770","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia\/Hif1\u03b1 prevents premature neuronal differentiation of neural stem cells through the activation of Hes1","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2020.101770","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101770"}}