{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:49:51Z","timestamp":1767995391859,"version":"3.49.0"},"reference-count":4,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570235"],"award-info":[{"award-number":["81570235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070272"],"award-info":[{"award-number":["82070272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202225"],"award-info":[{"award-number":["7202225"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.scr.2020.102152","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T01:53:13Z","timestamp":1609725193000},"page":"102152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Generation of a homozygous COX6A2 knockout human embryonic stem cell line (WAe009-A-47) via an epiCRISPR\/Cas9 system"],"prefix":"10.1016","volume":"50","author":[{"given":"Chengwen","family":"Hang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxiu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.scr.2020.102152_b0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ana.25517","article-title":"COX6A2 variants cause a muscle-specific cytochrome c oxidase deficiency","volume":"86","author":"Inoue","year":"2019","journal-title":"Ann. Neurol."},{"issue":"18","key":"10.1016\/j.scr.2020.102152_b0010","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105759","article-title":"Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function","volume":"39","author":"Sanz-Morello","year":"2020","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.scr.2020.102152_b0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36738-w","article-title":"Author Correction: An episomal vector-based CRISPR\/Cas9 system for highly efficient gene knockout in human pluripotent stem cells","volume":"8","author":"Xie","year":"2018","journal-title":"Sci Rep."},{"key":"10.1016\/j.scr.2020.102152_b0020","doi-asserted-by":"crossref","DOI":"10.1002\/0471142905.hg2103s87","article-title":"Chemically Defined Culture and Cardiomyocyte Differentiation of Human Pluripotent Stem Cells","volume":"87","author":"Burridge","year":"2015","journal-title":"Current Protocols Human Genetics"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506120304530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506120304530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:33:31Z","timestamp":1761737611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506120304530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":4,"alternative-id":["S1873506120304530"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2020.102152","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of a homozygous COX6A2 knockout human embryonic stem cell line (WAe009-A-47) via an epiCRISPR\/Cas9 system","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2020.102152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102152"}}