{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:58:39Z","timestamp":1791421119169,"version":"4.3.3"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016923","name":"Hoansha Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07854"],"award-info":[{"award-number":["19K07854"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03569"],"award-info":[{"award-number":["20H03569"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.scr.2021.102486","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T03:24:20Z","timestamp":1628047460000},"page":"102486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules"],"prefix":"10.1016","volume":"55","author":[{"given":"Naoya","family":"Amimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneyasu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Shimohama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.scr.2021.102486_b0005","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s00429-016-1343-5","article-title":"Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon","volume":"222","author":"Alzu\u2019bi","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.scr.2021.102486_b0010","first-page":"1375","article-title":"Activin A directs striatal projection neuron differentiation of human pluripotent stem cells","volume":"142","author":"Arber","year":"2015","journal-title":"Developmet"},{"issue":"5","key":"10.1016\/j.scr.2021.102486_b0015","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.stemcr.2020.03.018","article-title":"Stem cell-derived human striatal progenitors innervate striatal targets and alleviate sensorimotor deficit in a rat model of Huntington disease","volume":"14","author":"Besusso","year":"2020","journal-title":"Stem Cell Reports"},{"issue":"5","key":"10.1016\/j.scr.2021.102486_b0020","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/stem.408","article-title":"Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1\/S phase transition and accelerates neuronal differentiation in vitro and in vivo","volume":"28","author":"Borghese","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.scr.2021.102486_b0025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1242\/dev.084608","article-title":"Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons","volume":"140","author":"Carri","year":"2013","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.scr.2021.102486_b0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.scr.2021.102486_b0035","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/brain\/awr052","article-title":"Cell proliferation in human ganglionic eminence and suppression after prematurity-associated haemorrhage","volume":"134","author":"Del Bigio","year":"2011","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.scr.2021.102486_b0040","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.stemcr.2014.01.013","article-title":"Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation","volume":"2","author":"Doi","year":"2014","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.scr.2021.102486_b0045","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.stem.2008.09.002","article-title":"Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals","volume":"3","author":"Eiraku","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"36","key":"10.1016\/j.scr.2021.102486_b0050","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.1523\/JNEUROSCI.2750-07.2007","article-title":"Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes","volume":"27","author":"Flames","year":"2007","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.scr.2021.102486_b0055","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10616-020-00406-7","article-title":"Generation of GABAergic striatal neurons by a novel iPSC differentiation protocol enabling scalability and cryopreservation of progenitor cells","volume":"72","author":"Grigor\u2019eva","year":"2020","journal-title":"Cytotechnology"},{"issue":"3","key":"10.1016\/j.scr.2021.102486_b0060","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/joa.12416","article-title":"Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon","volume":"228","author":"Harkin","year":"2016","journal-title":"J. Anat."},{"issue":"7264","key":"10.1016\/j.scr.2021.102486_b0065","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nature08356","article-title":"Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling","volume":"461","author":"Huang","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.scr.2021.102486_b0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev-neuro-062111-150543","article-title":"The role of organizers in patterning the nervous system","volume":"35","author":"Kiecker","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.scr.2021.102486_b0075","doi-asserted-by":"crossref","first-page":"775","DOI":"10.5966\/sctm.2014-0083","article-title":"In vitro differentiation of human neural progenitor cells into striatal GABAergic neurons","volume":"4","author":"Lin","year":"2015","journal-title":"Stem Cells Transl. Med."},{"issue":"4","key":"10.1016\/j.scr.2021.102486_b0080","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/stem.1622","article-title":"Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors","volume":"32","author":"Lippmann","year":"2014","journal-title":"Stem Cells"},{"issue":"4","key":"10.1016\/j.scr.2021.102486_b0085","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.stem.2012.01.021","article-title":"Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice","volume":"10","author":"Ma","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"12","key":"10.1016\/j.scr.2021.102486_b0090","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/s41587-020-00763-w","article-title":"Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells","volume":"38","author":"Miura","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.scr.2021.102486_b0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jnr.22547","article-title":"Small-molecule inhibitors of bone morphogenic protein and activin\/nodal signals promote highly efficient neural induction from human pluripotent stem cells","volume":"89","author":"Morizane","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.scr.2021.102486_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep03594","article-title":"A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells","volume":"4","author":"Nakagawa","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scr.2021.102486_b0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fnana.2013.00054","article-title":"Organization of the human fetal subpallium","volume":"7","author":"Pauly","year":"2014","journal-title":"Front. Neuroanat."},{"issue":"2","key":"10.1016\/j.scr.2021.102486_b0110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nbt.3777","article-title":"Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells","volume":"35","author":"Qi","year":"2017","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.scr.2021.102486_b0115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nchembio753","article-title":"Purmorphamine activates the Hedgehog pathway by targeting Smoothened","volume":"2","author":"Sinha","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.scr.2021.102486_b0120","doi-asserted-by":"crossref","first-page":"15030","DOI":"10.1038\/mtm.2015.30","article-title":"Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons","volume":"2","author":"Straccia","year":"2015","journal-title":"Mol. Ther. - Methods Clin. Dev."},{"issue":"5","key":"10.1016\/j.scr.2021.102486_b0125","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.scr.2021.102486_b0130","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"issue":"9557","key":"10.1016\/j.scr.2021.102486_b0135","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.scr.2021.102486_b0140","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0896-6273(00)00171-9","article-title":"Induction and dorsoventral patterning of the telencephalon","volume":"28","author":"Wilson","year":"2000","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.scr.2021.102486_b0145","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.stemcr.2018.08.005","article-title":"A chemical recipe for generation of clinical-grade striatal neurons from hESCs","volume":"11","author":"Wu","year":"2018","journal-title":"Stem Cell Reports"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506121003330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506121003330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:34:51Z","timestamp":1761737691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506121003330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":29,"alternative-id":["S1873506121003330"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2021.102486","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2021.102486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102486"}}