{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:04:52Z","timestamp":1761746692563,"version":"build-2065373602"},"reference-count":6,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","award":["182102311215"],"award-info":[{"award-number":["182102311215"]}],"id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.scr.2021.102562","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:16:31Z","timestamp":1633652191000},"page":"102562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A CRISPR\/Cas9 strategy for the generation of a FLNC knockout hESC line (WAe009-A-70) to model dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy"],"prefix":"10.1016","volume":"56","author":[{"given":"Zhiping","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.scr.2021.102562_b0005","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/jmedgenet-2019-106394","article-title":"FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy","volume":"57","author":"Brun","year":"2020","journal-title":"J. Med. Genet."},{"issue":"17","key":"10.1016\/j.scr.2021.102562_b0010","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1128\/MCB.00243-06","article-title":"Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure","volume":"26","author":"Dalkilic","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.scr.2021.102562_b0015","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/jcm10040577","article-title":"Cardiac filaminopathies: illuminating the divergent role of filamin C mutations in human cardiomyopathy","volume":"10","author":"Eden","year":"2021","journal-title":"J. Clin. Med."},{"issue":"22","key":"10.1016\/j.scr.2021.102562_b0020","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.jacc.2016.09.927","article-title":"Truncating FLNC mutations are associated with high-risk dilated and arrhythmogenic cardiomyopathies","volume":"68","author":"Ortiz-Genga","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.scr.2021.102562_b0025","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6326","article-title":"Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy","volume":"5","author":"Vald\u00e9s-Mas","year":"2014","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.scr.2021.102562_b0030","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/CIRCULATIONAHA.119.044061","article-title":"Loss of filamin C is catastrophic for heart function","volume":"141","author":"Zhou","year":"2020","journal-title":"Circulation"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506121004098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506121004098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:36:36Z","timestamp":1761737796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506121004098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":6,"alternative-id":["S1873506121004098"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2021.102562","relation":{},"ISSN":["1873-5061"],"issn-type":[{"type":"print","value":"1873-5061"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A CRISPR\/Cas9 strategy for the generation of a FLNC knockout hESC line (WAe009-A-70) to model dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2021.102562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102562"}}