{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:41:43Z","timestamp":1792784503788,"version":"4.5.0"},"reference-count":4,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hundred Talents Program of Hebei Province","award":["E2019050019"],"award-info":[{"award-number":["E2019050019"]}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z200024"],"award-info":[{"award-number":["Z200024"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7232045"],"award-info":[{"award-number":["7232045"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["NV20230011"],"award-info":[{"award-number":["NV20230011"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503800"],"award-info":[{"award-number":["2022YFC2503800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Capital Health Research and Development of Special grants"},{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2020-1-2013"],"award-info":[{"award-number":["2020-1-2013"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["H2022206562"],"award-info":[{"award-number":["H2022206562"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China grant"},{"name":"Key laboratory of Neural and Vascular Biology, Ministry of Education of China"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.scr.2025.103749","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T21:09:04Z","timestamp":1749157744000},"page":"103749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Establishment of a human induced pluripotent stem cell (iPSC) line from a patient harboring a TSC1 gene mutation"],"prefix":"10.1016","volume":"87","author":[{"given":"Shiwen","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2982-8824","authenticated-orcid":false,"given":"Qian","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.scr.2025.103749_b0005","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/s41380-023-02402-7","article-title":"The role of TSC1 and TSC2 proteins in neuronal axons","volume":"29","author":"Karalis","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.scr.2025.103749_b0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scr.2025.103749_b0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pediatrneurol.2021.09.017","article-title":"Epilepsy management in tuberous sclerosis complex: existing and evolving therapies and future considerations","volume":"126","author":"Nouri","year":"2022","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.scr.2025.103749_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2022.102908","article-title":"Generation of an induced pluripotent stem cell lines HMSCASTi001-A from peripheral blood mononuclear cells of a 35-year-old healthy male","volume":"64","author":"Zhang","year":"2022","journal-title":"Stem Cell Res."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506125000996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506125000996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:31:12Z","timestamp":1776843072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506125000996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":4,"alternative-id":["S1873506125000996"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2025.103749","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of a human induced pluripotent stem cell (iPSC) line from a patient harboring a TSC1 gene mutation","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2025.103749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103749"}}