{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:26:27Z","timestamp":1776846387269,"version":"3.51.2"},"reference-count":5,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.scr.2025.103755","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:20:03Z","timestamp":1750209603000},"page":"103755","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Generation of a set of genetically modified long QT syndrome induced pluripotent stem cell lines carrying knock-in variants rs120074178 (KCNQ1 c.569G\u00a0&gt;\u00a0A; p.Arg190Gln) and rs137854600 (SCN5A c.4865G\u00a0&gt;\u00a0A; p.Arg1622Gln) and isogenic control lines"],"prefix":"10.1016","volume":"87","author":[{"given":"Nayara Sousa da","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"D\u2019Antonio-Chronowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyna","family":"Hernandez-Benitez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelina Rose","family":"McCarron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Izpisua Belmonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasia D.","family":"Panopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-8902","authenticated-orcid":false,"given":"Kelly A.","family":"Frazer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.scr.2025.103755_b0005","doi-asserted-by":"crossref","first-page":"e3469","DOI":"10.21769\/BioProtoc.3469","article-title":"In vitroDifferentiation of Human iPSC-derived Retinal Pigment Epithelium Cells (iPSC-RPE)","volume":"9","author":"D\u2019Antonio-Chronowska","year":"2019","journal-title":"Bio-Protocol"},{"issue":"4","key":"10.1016\/j.scr.2025.103755_b0010","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.stemcr.2017.03.012","article-title":"iPSCORE: a Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types","volume":"8","author":"Panopoulos","year":"2017","journal-title":"Stem Cell Rep."},{"issue":"4","key":"10.1016\/j.scr.2025.103755_b0015","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCEP.111.962019","article-title":"Long-QT syndrome: from genetics to management","volume":"5","author":"Schwartz","year":"2012","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"5","key":"10.1016\/j.scr.2025.103755_b0020","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.joa.2015.12.006","article-title":"Molecular pathogenesis of long QT syndrome type 1","volume":"32","author":"Wu","year":"2016","journal-title":"Journal of Arrhythmia"},{"key":"10.1016\/j.scr.2025.103755_b0025","doi-asserted-by":"crossref","unstructured":"Zaklyazminskaya, E., & Dzemeshkevich, S. (2016). The role of mutations in the SCN5A gene in cardiomyopathies. Biochimica et biophysica acta, 1863(7 Pt B), 1799\u20131805. https:\/\/doi.org\/10.1016\/j.bbamcr.2016.02.014.","DOI":"10.1016\/j.bbamcr.2016.02.014"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506125001059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506125001059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:30:36Z","timestamp":1776843036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506125001059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":5,"alternative-id":["S1873506125001059"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2025.103755","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of a set of genetically modified long QT syndrome induced pluripotent stem cell lines carrying knock-in variants rs120074178 (KCNQ1 c.569G\u00a0>\u00a0A; p.Arg190Gln) and rs137854600 (SCN5A c.4865G\u00a0>\u00a0A; p.Arg1622Gln) and isogenic control lines","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2025.103755","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103755"}}