{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:44:34Z","timestamp":1782906274000,"version":"3.54.5"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer&apos;s Association","doi-asserted-by":"publisher","award":["AARG-22-974344"],"award-info":[{"award-number":["AARG-22-974344"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA125123"],"award-info":[{"award-number":["P30 CA125123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50HD103555"],"award-info":[{"award-number":["P50HD103555"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.scr.2025.103759","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T19:17:53Z","timestamp":1750879073000},"page":"103759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Generation of human induced pluripotent stem cell line from a familial Alzheimer\u2019s disease patient carrying missense mutations in PSEN1 and MAPT genes"],"prefix":"10.1016","volume":"87","author":[{"given":"Ashaq H.","family":"Najar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia E.","family":"Sepulveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Gherardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Elahian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Fontenot-Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Bajic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-3249","authenticated-orcid":false,"given":"Abhisek","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2025.103759_b0005","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/mtm.2016.57","article-title":"Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR\/Cas9 for efficient gene editing","volume":"3","author":"Park","year":"2016","journal-title":"Molecular Therapy Methods & Clinical Development."},{"issue":"8","key":"10.1016\/j.scr.2025.103759_b0010","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2183\/pjab.85.348","article-title":"Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome","volume":"85","author":"Fusaki","year":"2009","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"issue":"1","key":"10.1016\/j.scr.2025.103759_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12017-009-8104-z","article-title":"An overview of APP processing enzymes and products","volume":"12","author":"Chow","year":"2010","journal-title":"Neuromolecular Med."},{"issue":"1","key":"10.1016\/j.scr.2025.103759_b0020","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(00)02076-7","article-title":"Regulation of APP cleavage by \u03b1-, \u03b2- and \u03b3-secretases","volume":"483","author":"Nunan","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.scr.2025.103759_b0025","doi-asserted-by":"crossref","unstructured":"Nikolac Perkovic M, Pivac N. Genetic Markers of Alzheimer\u2019s Disease. In: Kim YK, editor. Frontiers in Psychiatry: Artificial Intelligence, Precision Medicine, and Other Paradigm Shifts [Internet]. Singapore: Springer; 2019 [cited 2024 May 1]. p. 27\u201352. Available from: doi: 10.1007\/978-981-32-9721-0_3.","DOI":"10.1007\/978-981-32-9721-0_3"},{"issue":"5","key":"10.1016\/j.scr.2025.103759_b0030","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/gim.2015.117","article-title":"The genetic landscape of Alzheimer disease: clinical implications and perspectives","volume":"18","author":"Van Cauwenberghe","year":"2016","journal-title":"Genet. Med."},{"issue":"4","key":"10.1016\/j.scr.2025.103759_b0035","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1073\/pnas.1619574114","article-title":"Presenilin-1 mutations and Alzheimer\u2019s disease","volume":"114","author":"Kelleher","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.scr.2025.103759_b0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3233\/JAD-215167","article-title":"Very Early-Onset Alzheimer\u2019s Disease in the Third Decade of Life with de novo PSEN1 Mutations","volume":"85","author":"Chen","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.scr.2025.103759_b0045","doi-asserted-by":"crossref","first-page":"215.e15","DOI":"10.1016\/j.neurobiolaging.2018.11.024","article-title":"Mutation screening in chinese patients with familial Alzheimer\u2019s disease by whole-exome sequencing","volume":"76","author":"Jiang","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.scr.2025.103759_b0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/alz.12646","article-title":"Identification of the A\u03b237\/42 peptide ratio in CSF as an improved A\u03b2 biomarker for Alzheimer\u2019s disease","volume":"19","author":"Liu","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"7","key":"10.1016\/j.scr.2025.103759_b0055","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41374-019-0197-x","article-title":"MAPT mutations, tauopathy, and mechanisms of neurodegeneration","volume":"99","author":"Strang","year":"2019","journal-title":"Lab. Invest."},{"issue":"5","key":"10.1016\/j.scr.2025.103759_b0060","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nmeth.1593","article-title":"Chemically defined conditions for human iPSC derivation and culture","volume":"8","author":"Chen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scr.2025.103759_b0065","article-title":"Generation of human induced pluripotent stem cell line (BCRTi006-a) from a patient with focal segmental glomerulosclerosis disease","volume":"69","author":"Batool","year":"2023","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.scr.2025.103759_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2021.102533","article-title":"Establishment of human induced pluripotent stem cell line (SDQLCHi040-a) from a patient with Infantile-onset inflammatory bowel disease carrying a homozygous mutation in IL10RA gene","volume":"56","author":"Liu","year":"2021","journal-title":"Stem Cell Res."}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506125001096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506125001096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:57:56Z","timestamp":1778828276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506125001096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":14,"alternative-id":["S1873506125001096"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2025.103759","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of human induced pluripotent stem cell line from a familial Alzheimer\u2019s disease patient carrying missense mutations in PSEN1 and MAPT genes","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2025.103759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103759"}}