{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:58:23Z","timestamp":1786996703828,"version":"build-2736575974"},"reference-count":8,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","award":["FDT202304016375"],"award-info":[{"award-number":["FDT202304016375"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-22CE12-0007"],"award-info":[{"award-number":["ANR-22CE12-0007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"J\u00e9r\u00f4me Lejeune Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004923","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013465","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"Minist\u00e8re de l'Enseignement sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.scr.2026.103940","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:20:49Z","timestamp":1771226449000},"page":"103940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Generation of the iPSC line CRNLi001-A from a patient with microcephaly and harbouring the most recurrent RTTN variant, c.2953A&gt;G, at homozygous state"],"prefix":"10.1016","volume":"92","author":[{"given":"Justine","family":"Guguin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Besson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Nait","family":"Atmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire El","family":"Yazidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Hadadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Broucqsault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Magdinier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-4457","authenticated-orcid":false,"given":"Marion","family":"Delous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2026.103940_b0005","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ejmg.2018.08.001","article-title":"Recurrent RTTN mutation leading to severe microcephaly, polymicrogyria and growth restriction","volume":"61","author":"Cavallin","year":"2018","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.scr.2026.103940_b0010","first-page":"1","article-title":"Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scr.2026.103940_b0015","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.3390\/cells10061441","article-title":"Human Microcephaly Protein RTTN is Required for proper Mitotic Progression and Correct Spindle Position","volume":"10","author":"Chou","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.scr.2026.103940_b0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4773(02)00003-5","article-title":"Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos","volume":"113","author":"Faisst","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.scr.2026.103940_b0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/cge.12771","article-title":"Expanding the phenotype of RTTN variations: a new family with primary microcephaly, severe growth failure, brain malformations and dermatitis","volume":"90","author":"Grandone","year":"2016","journal-title":"Clin. Genet."},{"key":"10.1016\/j.scr.2026.103940_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011517","article-title":"A Taybi-Linder syndrome-related RTTN variant impedes neural rosette formation in human cortical organoids","volume":"20","author":"Guguin","year":"2024","journal-title":"PLoS Genet."},{"key":"10.1016\/j.scr.2026.103940_b0035","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scr.2026.103940_b0040","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/brain\/awz045","article-title":"Heterogeneous clinical phenotypes and cerebral malformations reflected by rotatin cellular dynamics","volume":"142","author":"Vandervore","year":"2019","journal-title":"Brain"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187350612600036X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187350612600036X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T16:44:11Z","timestamp":1775493851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187350612600036X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":8,"alternative-id":["S187350612600036X"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2026.103940","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of the iPSC line CRNLi001-A from a patient with microcephaly and harbouring the most recurrent RTTN variant, c.2953A>G, at homozygous state","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2026.103940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103940"}}