{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:52:54Z","timestamp":1777895574876,"version":"3.51.4"},"reference-count":9,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007623","name":"Emory University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.scr.2026.103960","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:21:20Z","timestamp":1772731280000},"page":"103960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Characterization of an induced pluripotent stem cell line from a long QT syndrome type 1 patient possessing the KCNQ1 c.691C\u00a0&gt;\u00a0T (p.Arg231Cys) variant"],"prefix":"10.1016","volume":"92","author":[{"given":"Jonathan","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingqian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa Marie","family":"Gollatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Harbuzariu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-5050","authenticated-orcid":false,"given":"Ilanit","family":"Itzhaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2026.103960_b0005","doi-asserted-by":"crossref","unstructured":"Aiba, T., Ohno, S., Takegami, M., Kato, Y., Sakaguchi, H., Shimamoto, K., Sonoda, K., Ida, K., Sumitomo, N., Nabeshima, T., Murakami, T., Ninomiya, Y., Kato, K., Fukuyama, M., Makiyama, T., Hayashi, K., Ohta, K., Morita, H., Nakajima, T., Kaneko, Y., Yagihara, N., Otsuki, S., Kosho, T., Yoshida, Y., Takamuro, M., Ueno, M., Takahashi, T., Inden, Y., Hayabuchi, Y., Muraji, S., Watanabe, S., Nishimura, K., Asano, Y., Horigome, H., Yoshinaga, M., Horie, M., Shimizu, W., Kusano, K., 2025. Clinical Impact of Genetic Testing for Long QT Syndrome \u2013 Evidence From a Nationwide LQTS Registry in Japan. Circulation Journal 89, 835\u2013844. https:\/\/doi.org\/10.1253\/CIRCJ.CJ-25-0105. Epub 2025\/05\/23. PubMed PMID: 40159220.","DOI":"10.1253\/circj.CJ-25-0105"},{"issue":"3","key":"10.1016\/j.scr.2026.103960_b0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.hrthm.2013.11.021","article-title":"A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase a phosphorylation","volume":"11","author":"Bartos","year":"2014","journal-title":"Heart Rhythm"},{"issue":"11","key":"10.1016\/j.scr.2026.103960_b0015","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cpcardiol.2008.07.002","article-title":"Long QT Syndrome","volume":"33","author":"Goldenberg","year":"2008","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.scr.2026.103960_b0020","article-title":"Long QT Syndrome with drugs used in the Management of Arrhythmias: a Systematic Review","volume":"16","author":"Khan","year":"2024","journal-title":"Cureus"},{"issue":"15","key":"10.1016\/j.scr.2026.103960_b0025","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa0908679","article-title":"Patient-specific induced pluripotent stem-cell models for long-QT syndrome","volume":"363","author":"Moretti","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.scr.2026.103960_b0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.hroo.2021.01.006","article-title":"Long QT syndrome - Bench to bedside","volume":"2","author":"Ponce-Balbuena","year":"2021","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.scr.2026.103960_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2025.103827","article-title":"Generation of three induced pluripotent stem cell lines from a long QT syndrome type 2 family harboring the pathogenic KCNH2 c.209A > G (p.His70Arg) variant","volume":"88","author":"Scislowicz","year":"2025","journal-title":"Stem Cell Res."},{"issue":"5","key":"10.1016\/j.scr.2026.103960_b0040","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.joa.2015.12.006","article-title":"Molecular pathogenesis of long QT syndrome type 1","volume":"32","author":"Wu","year":"2016","journal-title":"Journal of Arrhythmia"},{"issue":"8","key":"10.1016\/j.scr.2026.103960_b0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.hroo.2024.07.006","article-title":"From genes to clinical management: a comprehensive review of long QT syndrome pathogenesis and treatment","volume":"5","author":"Zhu","year":"2024","journal-title":"Heart Rhythm O2"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506126000565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506126000565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:55:24Z","timestamp":1777622124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506126000565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":9,"alternative-id":["S1873506126000565"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2026.103960","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of an induced pluripotent stem cell line from a long QT syndrome type 1 patient possessing the KCNQ1 c.691C\u00a0>\u00a0T (p.Arg231Cys) variant","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2026.103960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103960"}}