{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:28:27Z","timestamp":1789925307993,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008267","name":"Parker H. Petit Institute for Bioengineering and Bioscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007623","name":"Emory University School of Medicine","doi-asserted-by":"publisher","award":["00130739"],"award-info":[{"award-number":["00130739"]}],"id":[{"id":"10.13039\/100007623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.scr.2026.103998","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:17:57Z","timestamp":1776701877000},"page":"103998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Derivation of an induced pluripotent stem cell line from a long QT syndrome type 1 patient with a pathogenic KCNQ1 c.1552C\u00a0>\u00a0T (p.Arg518Ter) variant"],"prefix":"10.1016","volume":"94","author":[{"given":"Dingqian","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Marie","family":"Gollatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Harbuzariu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-5050","authenticated-orcid":false,"given":"Ilanit","family":"Itzhaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scr.2026.103998_b0005","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1253\/circj.CJ-25-0105","article-title":"Clinical impact of genetic testing for long QT syndrome \u2013 evidence from a nationwide LQTS registry in Japan","volume":"89","author":"Aiba","year":"2025","journal-title":"Circ. J."},{"issue":"6","key":"10.1016\/j.scr.2026.103998_b0010","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40272-014-0090-4","article-title":"Congenital long QT syndromes: prevalence, pathophysiology and management","volume":"16","author":"Barsheshet","year":"2014","journal-title":"Pediatr. Drugs"},{"issue":"3","key":"10.1016\/j.scr.2026.103998_b0015","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.hrthm.2013.11.021","article-title":"A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation","volume":"11","author":"Bartos","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.scr.2026.103998_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2026.103960","article-title":"Characterization of an induced pluripotent stem cell line from a long QT syndrome type 1 patient possessing the KCNQ1 c.691C > T (p.Arg231Cys) variant","volume":"92","author":"Choi","year":"2026","journal-title":"Stem Cell Res."},{"issue":"7337","key":"10.1016\/j.scr.2026.103998_b0025","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature09747","article-title":"Modelling the long QT syndrome with induced pluripotent stem cells","volume":"471","author":"Itzhaki","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.scr.2026.103998_b0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1212\/01.wnl.0000335760.02995.ca","article-title":"Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy","volume":"72","author":"Johnson","year":"2009","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.scr.2026.103998_b0035","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jacep.2022.02.017","article-title":"Congenital long QT syndrome","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC Clin. Electrophysiol."},{"issue":"7","key":"10.1016\/j.scr.2026.103998_b0040","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/CIRCULATIONAHA.123.067590","article-title":"Vigorous Exercise in patients with congenital long QT syndrome: results of the prospective, observational, multinational LIVE-LQTS study","volume":"150","author":"Lampert","year":"2024","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.scr.2026.103998_b0045","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1161\/CIRCULATIONAHA.106.665406","article-title":"Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene","volume":"115","author":"Moss","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.scr.2026.103998_b0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.yjmcc.2014.11.020","article-title":"Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion\/arousal triggered events in LQT1","volume":"79","author":"O-Uchi","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.scr.2026.103998_b0055","first-page":"7","article-title":"Correlation between seizure in children and prolonged QT interval","volume":"9","author":"Sadrnia","year":"2013","journal-title":"ARYA Atheroscler."},{"issue":"4","key":"10.1016\/j.scr.2026.103998_b0060","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCEP.111.962019","article-title":"Long-QT syndrome from genetics to management","volume":"5","author":"Schwartz","year":"2012","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"18","key":"10.1016\/j.scr.2026.103998_b0065","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1161\/CIRCULATIONAHA.109.863209","article-title":"Prevalence of the congenital long-qt syndrome","volume":"120","author":"Schwartz","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.scr.2026.103998_b0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.reth.2015.12.001","article-title":"Electrophysiological properties of iPS cell-derived cardiomyocytes from a patient with long QT syndrome type 1 harboring the novel mutation M437V of KCNQ1","volume":"4","author":"Sogo","year":"2016","journal-title":"Regen. Ther."},{"key":"10.1016\/j.scr.2026.103998_b0075","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7532657","article-title":"Optical recording of action potentials in human induced pluripotent stem cell-derived cardiac single cells and monolayers generated from long QT syndrome type 1 patients","volume":"2019","author":"Takaki","year":"2019","journal-title":"Stem Cells Int."},{"issue":"5","key":"10.1016\/j.scr.2026.103998_b0080","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.joa.2015.12.006","article-title":"Molecular pathogenesis of long QT syndrome type 1","volume":"32","author":"Wu","year":"2016","journal-title":"J. Arrhythmia"},{"issue":"8","key":"10.1016\/j.scr.2026.103998_b0085","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jamacardio.2023.1951","article-title":"Association between syncope trigger type and risk of subsequent life-threatening events in patients with long QT syndrome","volume":"8","author":"Younis","year":"2023","journal-title":"JAMA Cardiol."},{"issue":"8","key":"10.1016\/j.scr.2026.103998_b0090","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.hroo.2024.07.006","article-title":"From genes to clinical management: a comprehensive review of long QT syndrome pathogenesis and treatment","volume":"5","author":"Zhu","year":"2024","journal-title":"Heart Rhythm O2"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506126000942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506126000942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:05:58Z","timestamp":1786115158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506126000942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":18,"alternative-id":["S1873506126000942"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2026.103998","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Derivation of an induced pluripotent stem cell line from a long QT syndrome type 1 patient with a pathogenic KCNQ1 c.1552C\u00a0>\u00a0T (p.Arg518Ter) variant","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2026.103998","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103998"}}