{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:12:02Z","timestamp":1789074722865,"version":"build-2803163510"},"reference-count":9,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017732","name":"E-Rare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021269","name":"National Organization for Women","doi-asserted-by":"publisher","award":["OCENW.XS24.4.294"],"award-info":[{"award-number":["OCENW.XS24.4.294"]}],"id":[{"id":"10.13039\/100021269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021269","name":"National Organization for Women","doi-asserted-by":"publisher","award":["019.242EN.016"],"award-info":[{"award-number":["019.242EN.016"]}],"id":[{"id":"10.13039\/100021269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.scr.2026.104089","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:37:17Z","timestamp":1787787437000},"page":"104089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Generation and characterization of an isogenic gene-corrected iPSC line CARIMi009-A-1 from a Hutchinson-Gilford Progeria Syndrome (HGPS) patient with a heterozygous G608G mutation in the LMNA gene"],"prefix":"10.1016","volume":"95","author":[{"given":"Giuliana","family":"Lezzoche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Ntotsia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Seyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"De Majo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serv\u00e9","family":"Olieslagers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Mostert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-2856","authenticated-orcid":false,"given":"Leon J.","family":"de Windt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.scr.2026.104089_b0005","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/acel.12621","article-title":"Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape","volume":"16","author":"Chen","year":"2017","journal-title":"Aging Cell"},{"issue":"6937","key":"10.1016\/j.scr.2026.104089_b0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature01629","article-title":"Recurrent de novo point mutations in lamin A cause Hutchinson\u2013Gilford progeria syndrome","volume":"423","author":"Eriksson","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.scr.2026.104089_b0015","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ceb.2015.05.007","article-title":"DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome","volume":"34","author":"Gonzalo","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.scr.2026.104089_b0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-physiol-021317-121454","article-title":"Aging in the cardiovascular system: lessons from hutchinson-gilford progeria syndrome","volume":"80","author":"Hamczyk","year":"2018","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.scr.2026.104089_b0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41419-025-07853-0","article-title":"The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome","volume":"16","author":"Kim","year":"2025","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.scr.2026.104089_b0030","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1056\/NEJMoa0706898","article-title":"Phenotype and course of Hutchinson-Gilford progeria syndrome","volume":"358","author":"Merideth","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.scr.2026.104089_b0035","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14150","article-title":"Progeria-based vascular model identifies networks associated with cardiovascular aging and disease","volume":"23","author":"Ngubo","year":"2024","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.scr.2026.104089_b0040","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.scr.2026.104089_b0045","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s10522-025-10330-y","article-title":"Unraveling the mysteries of Hutchinson-Gilford progeria syndrome: a comprehensive review of LMNA gene mutations","volume":"26","author":"Zhou","year":"2025","journal-title":"Biogerontology"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506126001856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506126001856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:44:07Z","timestamp":1789073047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506126001856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":9,"alternative-id":["S1873506126001856"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2026.104089","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation and characterization of an isogenic gene-corrected iPSC line CARIMi009-A-1 from a Hutchinson-Gilford Progeria Syndrome (HGPS) patient with a heterozygous G608G mutation in the LMNA gene","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2026.104089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104089"}}