{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:23:46Z","timestamp":1773969826474,"version":"3.50.1"},"reference-count":63,"publisher":"Frontline Medical Communications, Inc.","issue":"2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Cutaneous Medicine and Surgery"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.sder.2007.02.005","type":"journal-article","created":{"date-parts":[[2007,6,3]],"date-time":"2007-06-03T11:03:59Z","timestamp":1180868639000},"page":"90-95","source":"Crossref","is-referenced-by-count":64,"title":["Deep Morphea"],"prefix":"10.12788","volume":"26","author":[{"given":"Isabel","family":"Bielsa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Ariza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5043","reference":[{"key":"10.1016\/j.sder.2007.02.005_bib1","series-title":"Scleroderma and Pseudoscleroderma","author":"Jablonska","year":"1975"},{"key":"10.1016\/j.sder.2007.02.005_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2133.1979.tb01636.x","article-title":"Subcutaneous morphea: A clinical study of sixteen cases","volume":"100","author":"Person","year":"1979","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00000372-198110000-00003","article-title":"Morphea profunda","volume":"3","author":"Su","year":"1981","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.sder.2007.02.005_bib4","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.4065\/70.11.1068","article-title":"Classification of morphea (localized scleroderma)","volume":"70","author":"Peterson","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.sder.2007.02.005_bib5","series-title":"Scleroderma and Pseudoscleroderma","author":"Jablonska","year":"1965"},{"key":"10.1016\/j.sder.2007.02.005_bib6","first-page":"83","article-title":"Classification and pathogenesis of scleroderma","volume":"46","author":"Winkelmann","year":"1971","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.sder.2007.02.005_bib7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/archderm.1972.01620130041010","article-title":"Generalized morphea I","volume":"106","author":"Fleischmajer","year":"1972","journal-title":"Arch Dermatol"},{"issue":"suppl 1","key":"10.1016\/j.sder.2007.02.005_bib8","first-page":"46","article-title":"Diffuse fasciitis with hypergammaglobulinemia and eosinophilia: A new syndrome?","volume":"1","author":"Shulman","year":"1974","journal-title":"J Rheumatol"},{"key":"10.1016\/j.sder.2007.02.005_bib9","first-page":"443A","article-title":"Eosinophilic fasciitis: Report of six cases of a newly recognized scleroderma-like syndrome","volume":"23","author":"Rodnan","year":"1975","journal-title":"Clin Res"},{"key":"10.1016\/j.sder.2007.02.005_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1001\/archderm.1980.01640260045011","article-title":"Disabling pansclerotic morphea of children","volume":"116","author":"D\u00edaz-Perez","year":"1980","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib11","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1001\/archderm.1982.01650230014018","article-title":"Cutaneous and subcutaneous inflammatory sclerosis syndromes","volume":"118","author":"Doyle","year":"1982","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1365-4362.1991.tb04356.x","article-title":"Morphea profunda","volume":"30","author":"Sayama","year":"1991","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4615-4857-7_15","article-title":"Scleroderma profunda","volume":"455","author":"Balabanova","year":"1999","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.sder.2007.02.005_bib14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1046\/j.1365-2230.2002.10493.x","article-title":"Concurrent development of dermatomyositis and morphea profunda","volume":"27","author":"Park","year":"2002","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00000372-198604000-00009","article-title":"Bullous morphea profunda","volume":"8","author":"Su","year":"1986","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.sder.2007.02.005_bib16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0190-9622(94)70113-X","article-title":"Bullous morphea: Clinical, pathologic, and immunopathologic evaluation of thirteen cases","volume":"30","author":"Daoud","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib17","first-page":"792","article-title":"Morphea, fasciitis and scleroderma with eosinophilia: a broad spectrum of disease","volume":"19","author":"Caperton","year":"1976","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.sder.2007.02.005_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-4362.1980.tb00283.x","article-title":"Generalized morphea with peripheral eosinophilia: fasciitis and myositis","volume":"19","author":"King","year":"1980","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib19","first-page":"171","article-title":"Morfea generalizada: aspectos sist\u00e9micos de una enfermedad cut\u00e1nea","volume":"85","author":"Bielsa","year":"1985","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.sder.2007.02.005_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00005792-199409000-00002","article-title":"Internal involvement in localized scleroderma","volume":"73","author":"Dehen","year":"1994","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.sder.2007.02.005_bib21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1001\/archderm.1987.01660270088021","article-title":"Antinuclear and anti-single-stranded DNA antibodies in morphea and generalized morphea","volume":"123","author":"Falanga","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib22","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/archderm.1994.01690100057009","article-title":"Antigen specificity of antihistone antibodies in localized scleroderma","volume":"130","author":"Sato","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib23","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0190-9622(94)70217-9","article-title":"Clinical characteristics associated with antihistone antibodies in patients with localized scleroderma","volume":"31","author":"Sato","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000246474","article-title":"Antihistone antibodies in scleroderma","volume":"191","author":"Parodi","year":"1995","journal-title":"Dermatology"},{"key":"10.1016\/j.sder.2007.02.005_bib25","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1001\/archderm.1994.01690100053007","article-title":"Serum concentration of procollagen type I carboxyterminal propeptide in localized scleroderma","volume":"130","author":"Kikuchi","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib26","first-page":"19","article-title":"Anti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma","volume":"24","author":"Hasegawa","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2133.1989.tb04171.x","article-title":"Solitary morphea profunda","volume":"120","author":"Whittaker","year":"1989","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib28","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1525-1470.1991.tb00936.x","article-title":"Solitary morphea profunda in a 5-year-old girl: Case report and review of the literarture","volume":"8","author":"Kobayashi","year":"1991","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2133.1993.tb00156.x","article-title":"Solitary fibrosing paraspinal plaque: Solitary morphea profunda?","volume":"128","author":"Kirsner","year":"1993","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2230.2004.01422.x","article-title":"Does solitary morphea profunda progress?","volume":"29","author":"Azad","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1365-2133.1996.tb06334.x","article-title":"Perforating plate-like osteoma cutis in a man with solitary morphea profunda","volume":"134","author":"Ahn","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1365-2230.2003.01353.x","article-title":"Osteoma cutis in a lesion of solitary morphea profunda","volume":"28","author":"Julian","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib33","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1525-1470.2006.00289.x","article-title":"Deep morphea after vaccination in two young children","volume":"23","author":"Torrelo","year":"2006","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-4362.1995.tb01569.x","article-title":"Morphea-like reaction from vitamin K1","volume":"34","author":"Morell","year":"1995","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib35","first-page":"634","article-title":"Scleroderma-like patch on the thigh in infants after vitamin K injection at birth: Six observations","volume":"123","author":"Bourrat","year":"1996","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.sder.2007.02.005_bib36","first-page":"27","article-title":"Eosinophilic fasciitis: Report of 15 cases","volume":"56","author":"Michet","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.sder.2007.02.005_bib37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0049-0172(88)90008-X","article-title":"Eosinophilic fasciitis: Clinical spectrum and therapeutic response in 52 cases","volume":"17","author":"Lakhanpal","year":"1988","journal-title":"Sem Arthritis Rheum"},{"key":"10.1016\/j.sder.2007.02.005_bib38","first-page":"733","article-title":"The fasciitis-morphea complex in children","volume":"146","author":"Miller","year":"1992","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.sder.2007.02.005_bib39","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000246868","article-title":"Association of eosinophilic fasciitis, multiple morphea and antiphospholipid antibody","volume":"189","author":"Castanet","year":"1994","journal-title":"Dermatology"},{"key":"10.1016\/j.sder.2007.02.005_bib40","first-page":"493","article-title":"Eosinophilic fasciitis","volume":"96","author":"Barnes","year":"1979","journal-title":"Am J Pathol"},{"key":"10.1016\/j.sder.2007.02.005_bib41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/014107687907201017","article-title":"Eosinophilic fasciitis with megakaryocyte aplasia","volume":"72","author":"Griffin","year":"1979","journal-title":"J R Soc Med"},{"key":"10.1016\/j.sder.2007.02.005_bib42","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1056\/NEJM197903293001307","article-title":"Antibody-mediated aplastic anemia and diffuse fasciitis","volume":"300","author":"Hoffman","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sder.2007.02.005_bib43","first-page":"730","article-title":"Eosinophilic fasciitis and aplastic anemia","volume":"7","author":"Littlejohn","year":"1980","journal-title":"J Rheumatol"},{"key":"10.1016\/j.sder.2007.02.005_bib44","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/rheumatology\/37.12.1358","article-title":"Successful treatment with antithymocyte globulin and cyclosporine A of a severe aplastic anemia associated with an eosinophilic fasciitis","volume":"37","author":"Bonnotte","year":"1998","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.sder.2007.02.005_bib45","first-page":"1864","article-title":"Autoimmune haemolytic anemia associated with eosinophilic fasciitis","volume":"25","author":"Garc\u00eda","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.sder.2007.02.005_bib46","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1046\/j.1365-2133.1998.02535.x","article-title":"Eosinophilic fasciitis associated with low-grade T-cell lymphoma","volume":"139","author":"Masuoka","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00000441-199911000-00011","article-title":"Lymph-node-based malignant lymphoma and reactive lymphadenopathy in eosinophilic fasciitis","volume":"318","author":"Naschitz","year":"1999","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.sder.2007.02.005_bib48","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.jaad.2004.10.881","article-title":"Disabling pansclerotic morphea: Clinical presentation in two adults","volume":"53","author":"Maragh","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib49","first-page":"377","article-title":"Morfea panescler\u00f3tica incapacitante en nin\u00f5s","volume":"9","author":"Ferrandiz","year":"1981","journal-title":"Med Cutan Ibero Lat Am"},{"key":"10.1016\/j.sder.2007.02.005_bib50","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4103\/0378-6323.16237","article-title":"Unilateral linear pansclerotic morphea affecting face and limbs","volume":"71","author":"Padmavathy","year":"2005","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.sder.2007.02.005_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1365-2133.2001.04041.x","article-title":"Squamous cell carcinoma arising in a patient with long-standing pansclerotic morphea","volume":"144","author":"Parodi","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib52","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1525-1470.2002.00033.x","article-title":"Squamous cell carcinoma in pansclerotic morphea of childhood","volume":"19","author":"Wollina","year":"2002","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib53","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI116015","article-title":"Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin-4","volume":"90","author":"Posthlethwaite","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.sder.2007.02.005_bib54","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/archderm.1996.03890310088013","article-title":"Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures","volume":"132","author":"Salmon-Her","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib55","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/1523-1747.ep12345771","article-title":"Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders","volume":"106","author":"Igarashi","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib56","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1046\/j.1365-2133.2000.03886.x","article-title":"Analysis of dendritic cell populations using a revised histological staging of morphea","volume":"143","author":"Gilmour","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib57","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1002\/1529-0131(199912)42:12<2656::AID-ANR22>3.0.CO;2-N","article-title":"Autoantibodies to the extracellular matrix microfibrillar protein, fibrilin-1, in patients with localized scleroderma","volume":"42","author":"Arnett","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.sder.2007.02.005_bib58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S1085-5629(98)80060-6","article-title":"Management of localized scleroderma","volume":"17","author":"Hunzelmann","year":"1998","journal-title":"Semin Cut Med Surg"},{"key":"10.1016\/j.sder.2007.02.005_bib59","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0190-9622(98)70079-9","article-title":"Low-dose methotrexate in the treatment of widespread morphea","volume":"39","author":"Seyger","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib60","first-page":"2538","article-title":"Efficacy of bosentan in treatment of unresponsive cutaneous ulceration in disabling pansclerotic morphea in children","volume":"33","author":"Roldan","year":"2006","journal-title":"J Rheumatol"},{"key":"10.1016\/j.sder.2007.02.005_bib61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/sder.2001.23093","article-title":"Localized and systemic scleroderma","volume":"20","author":"Hawk","year":"2001","journal-title":"Semin Cut Med Surg"},{"key":"10.1016\/j.sder.2007.02.005_bib62","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0190-9622(97)70193-2","article-title":"Psoralen UVA therapy for linear and generalized morphea","volume":"37","author":"Morison","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.sder.2007.02.005_bib63","first-page":"201","article-title":"PUVA therapy for disabling pansclerotic morphea of children","volume":"1388","year":"1998","journal-title":"Br J Dermatol"}],"container-title":["Seminars in Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1085562907000065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1085562907000065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scmsjournal.com\/wp-content\/uploads\/2016\/08\/v26i2-Bielsa.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T15:09:56Z","timestamp":1616166596000},"score":1,"resource":{"primary":{"URL":"http:\/\/scmsjournal.com\/article\/buy_now\/?id=366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S1085562907000065"],"URL":"https:\/\/doi.org\/10.1016\/j.sder.2007.02.005","relation":{},"ISSN":["1085-5629"],"issn-type":[{"value":"1085-5629","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}