{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:48:19Z","timestamp":1773661699732,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2116,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.seizure.2007.05.008","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T07:09:18Z","timestamp":1182236958000},"page":"653-656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: An autopsy report of two patients"],"prefix":"10.1016","volume":"16","author":[{"given":"Giulio","family":"Di Mizio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gambardella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Labate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Perna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Quattrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2007.05.008_bib1","series-title":"Initiative of support to people with epilepsy","author":"World Health Organization","year":"1990"},{"key":"10.1016\/j.seizure.2007.05.008_bib2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.0013-9580.2004.12704.x","article-title":"Phenobarbital for the treatment of epilepsy in the 21st century: a critical review","volume":"45","author":"Kwan","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2007.05.008_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0022-3476(80)80123-5","article-title":"The effects of phenobarbital and diphenylhydantoin on liver function and morphology","volume":"97","author":"Aiges","year":"1980","journal-title":"J Pediatr"},{"key":"10.1016\/j.seizure.2007.05.008_bib4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMra052270","article-title":"Drug-related hepatotoxicity","volume":"354","author":"Navarro","year":"2006","journal-title":"N Eng J Med"},{"key":"10.1016\/j.seizure.2007.05.008_bib5","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcp\/74.4.442","article-title":"Hepatic injury associated with diphenylhydantoin therapy. A clinicopathologic study of 20 cases","volume":"74","author":"Mullick","year":"1980","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.seizure.2007.05.008_bib6","first-page":"270","article-title":"Barbiturate-induced submassive hepatic necrosis. Report of a case and review of the literature","volume":"74","author":"Shapiro","year":"1980","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.seizure.2007.05.008_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.7326\/0003-4819-111-6-473","article-title":"Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes?","volume":"111","author":"Van Ness","year":"1989","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.seizure.2007.05.008_bib8","first-page":"315","article-title":"Liver damage in long-term anticonvulsant therapy: a serological and histological study Q","volume":"79","author":"Foster","year":"1991","journal-title":"J Med"},{"key":"10.1016\/j.seizure.2007.05.008_bib9","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJMra020526","article-title":"Pharmacogenomics\u2014drug disposition, drug targets, and side effects","volume":"348","author":"Evans","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.seizure.2007.05.008_bib10","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1001\/archinte.144.8.1677","article-title":"Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital","volume":"144","author":"Kahn","year":"1984","journal-title":"Arch Int Med"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131107001069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131107001069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:36:07Z","timestamp":1761010567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131107001069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S1059131107001069"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2007.05.008","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: An autopsy report of two patients","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2007.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}