{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:41:33Z","timestamp":1792788093419,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1324,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Swedish Research Council-Medicine","id":[{"id":"https:\/\/ror.org\/03zttf063","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009670","name":"NARSAD","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Karolinska Institutet Foundation","id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Evy and Gunnar Sandberg Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.seizure.2009.09.002","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T15:22:52Z","timestamp":1255533772000},"page":"672-675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Population-based study of antiepileptic drug exposure in utero\u2014Influence on head circumference in newborns"],"prefix":"10.1016","volume":"18","author":[{"given":"Malin","family":"Almgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Lavebratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2009.09.002_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0890-6238(91)90091-S","article-title":"Parental epilepsy, anticonvulsant drugs and reproductive outcome: epidemiologic and experimental findings spanning three decades. 2. Human studies","volume":"5","author":"Dansky","year":"1991","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.seizure.2009.09.002_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0890-6238(91)90090-3","article-title":"Parental epilepsy, anticonvulsant drugs and reproductive outcome: epidemiologic and experimental findings spanning three decades. 1. Animal studies","volume":"5","author":"Finnell","year":"1991","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.seizure.2009.09.002_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0890-6238(01)00199-X","article-title":"The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures","volume":"16","author":"Matalon","year":"2002","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.seizure.2009.09.002_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.seizure.2007.11.016","article-title":"Teratogenic effects of antiepileptic drugs","volume":"17","author":"Tomson","year":"2008","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2009.09.002_bib5","first-page":"1489","article-title":"Epilepsy in women","volume":"66","author":"Morrell","year":"2002","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.seizure.2009.09.002_bib6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1471-0528.2000.tb11089.x","article-title":"Epilepsy and pregnancy: effect of antiepileptic drugs and lifestyle on birthweight","volume":"107","author":"Hvas","year":"2000","journal-title":"BJOG"},{"key":"10.1016\/j.seizure.2009.09.002_bib7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF00239754","article-title":"Anticonvulsant drugs in monotherapy effect on the fetus","volume":"3","author":"Bertollini","year":"1987","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.seizure.2009.09.002_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0140-6736(81)90354-8","article-title":"Fetal head growth retardation associated with maternal antiepileptic drugs","volume":"2","author":"Hiilesmaa","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.seizure.2009.09.002_bib9","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1528-1157.2000.tb00253.x","article-title":"Body dimensions of infants exposed to antiepileptic drugs in utero: observations spanning 25 years","volume":"41","author":"Wide","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2009.09.002_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1600-0404.1992.tb05485.x","article-title":"Intrauterine growth in the offspring of epileptic mothers","volume":"86","author":"Battino","year":"1992","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.seizure.2009.09.002_bib11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0028-3886.24701","article-title":"Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero","volume":"54","author":"Arulmozhi","year":"2006","journal-title":"Neurol India"},{"key":"10.1016\/j.seizure.2009.09.002_bib12","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1528-1167.2009.02129.x","volume":"50","author":"Harden","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2009.09.002_bib13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1056\/NEJM197311152892001","article-title":"Diphenylhydantoin and selected congenital malformations","volume":"289","author":"Monson","year":"1973","journal-title":"N Engl J Med"},{"key":"10.1016\/j.seizure.2009.09.002_bib14","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0301-2115(01)00545-0","article-title":"A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy","volume":"101","author":"Eros","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.seizure.2009.09.002_bib15","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/bdra.20051","article-title":"Clonazepam use in pregnancy and the risk of malformations","volume":"70","author":"Lin","year":"2004","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.seizure.2009.09.002_bib16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1525-5050(03)00110-0","article-title":"Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry","volume":"4","author":"Montouris","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2009.09.002_bib17","first-page":"47","article-title":"Teratogenic effects of the anticonvulsant gabapentin in mice","volume":"49","author":"Prakash","year":"2008","journal-title":"Singapore Med J"},{"key":"10.1016\/j.seizure.2009.09.002_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/jnnp.2005.074203","article-title":"Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register","volume":"77","author":"Morrow","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.seizure.2009.09.002_bib19","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/j.1528-1167.2007.01021.x","article-title":"Effect of dose on the frequency of major birth defects following fetal exposure to lamotrigine monotherapy in an international observational study","volume":"48","author":"Cunnington","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2009.09.002_bib20","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.222550499","article-title":"Antiepileptic drugs and apoptotic neurodegeneration in the developing brain","volume":"99","author":"Bittigau","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.seizure.2009.09.002_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2003.tb07517.x","article-title":"Antiepileptic drugs and apoptosis in the developing brain","volume":"993","author":"Bittigau","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.seizure.2009.09.002_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mrfmmm.2007.07.014","article-title":"Carbamazepine induces mitotic arrest in mammalian Vero cells","volume":"637","author":"P\u00e9rez Mart\u00edn","year":"2008","journal-title":"Mutat Res"},{"key":"10.1016\/j.seizure.2009.09.002_bib23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbrc.2007.03.063","article-title":"Estimation of the embryotoxic effect of CBZ using an ES cell differentiation system","volume":"356","author":"Murabe","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.seizure.2009.09.002_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/ddrr.64","article-title":"Plasticity in the developing brain: implications for rehabilitation","volume":"15","author":"Johnston","year":"2009","journal-title":"Dev Disabil Res Rev"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131109001848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131109001848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:38:12Z","timestamp":1761010692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131109001848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S1059131109001848"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2009.09.002","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Population-based study of antiepileptic drug exposure in utero\u2014Influence on head circumference in newborns","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2009.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}