{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:50:14Z","timestamp":1793998214962,"version":"4.8.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1025,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.seizure.2010.09.003","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T05:46:57Z","timestamp":1286171217000},"page":"562-566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population"],"prefix":"10.1016","volume":"19","author":[{"given":"Xiang-qing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-yang","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-bin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-jun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.seizure.2010.09.003_bib0005","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/jnnp.47.6.642","article-title":"Serum anticonvulsant concentrations and the risk of drug induced skin eruptions","volume":"47","author":"Chadwick","year":"1984","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"10.1016\/j.seizure.2010.09.003_bib0010","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/00004714-199412000-00006","article-title":"Rash complicating carbamazepine therapy","volume":"14","author":"Kramlinger","year":"1994","journal-title":"J Clin Psychopharmacol"},{"issue":"8948","key":"10.1016\/j.seizure.2010.09.003_bib0015","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0140-6736(95)90581-2","article-title":"Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy","volume":"345","author":"Brodie","year":"1995","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.seizure.2010.09.003_bib0020","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1212\/01.WNL.0000156354.20227.F0","article-title":"Risk of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics","volume":"64","author":"Mockenhaupt","year":"2005","journal-title":"Neurology"},{"issue":"1\u20132","key":"10.1016\/j.seizure.2010.09.003_bib0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0920-1211(01)00306-0","article-title":"Life-threatening adverse events of antiepileptic drugs","volume":"47","author":"Arroyo","year":"2001","journal-title":"Epilepsy Res"},{"issue":"7","key":"10.1016\/j.seizure.2010.09.003_bib0030","first-page":"S22","article-title":"Lamotrigine-induced severe cutaneous adverse reactions","volume":"39","author":"Schlienger","year":"1998","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.seizure.2010.09.003_bib0035","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1365-4632.2007.03561.x","article-title":"Severe cutaneous reactions caused by barbiturates in seven Iranian children","volume":"48","author":"Mamishi","year":"2009","journal-title":"Int J Dermatol"},{"issue":"5","key":"10.1016\/j.seizure.2010.09.003_bib0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1525-1470.2009.00870.x","article-title":"Retrospective analysis of 32 pediatric patients with anticonvulsant hypersensitivity syndrome (ACHSS)","volume":"26","author":"Newell","year":"2009","journal-title":"Pediatr Dermatol"},{"issue":"12","key":"10.1016\/j.seizure.2010.09.003_bib0045","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1111\/j.1528-1167.2008.01720.x","article-title":"Anticonvulsant hypersensitivity syndrome: is there a role for immunomodulation?","volume":"49","author":"Cumbo-Nacheli","year":"2008","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.seizure.2010.09.003_bib0050","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1999.tb00807.x","article-title":"Lamotrigine-associated rash: risk\u2013benefit considerations in adults and children","volume":"40","author":"Guberman","year":"1999","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.seizure.2010.09.003_bib0055","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1528-1157.1993.tb02392.x","article-title":"Cross-reactive skin eruption with both carbamazepine and oxcarbazepine","volume":"34","author":"Beran","year":"1993","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.seizure.2010.09.003_bib0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S0317167100021880","article-title":"Cross sensitivity of skin rashes with antiepileptic drugs","volume":"24","author":"Hyson","year":"1997","journal-title":"Can J Neurol Sci"},{"issue":"5","key":"10.1016\/j.seizure.2010.09.003_bib0065","first-page":"434","article-title":"Anticonvulsant hypersensitivity: an unfortunate case of triple exposure to phenytoin","volume":"45","author":"Brown","year":"1997","journal-title":"J Fam Pract"},{"issue":"6","key":"10.1016\/j.seizure.2010.09.003_bib0070","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1172\/JCI113798","article-title":"Anticonvulsant hypersensitivity syndrome: in vitro assessment of risk","volume":"82","author":"Shear","year":"1988","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.seizure.2010.09.003_bib0075","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2165\/00002018-200831080-00006","article-title":"Influence of chemical structure on hypersensitivity reactions induced by antiepileptic drugs: the role of the aromatic ring","volume":"31","author":"Handoko","year":"2008","journal-title":"Drug Saf"},{"issue":"2\u20133","key":"10.1016\/j.seizure.2010.09.003_bib0080","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.eplepsyres.2008.04.003","article-title":"Cross-reactivity pattern of rash from current aromatic antiepileptic drugs","volume":"80","author":"Alvestad","year":"2008","journal-title":"Epilepsy Res"},{"issue":"19","key":"10.1016\/j.seizure.2010.09.003_bib0085","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1212\/01.wnl.0000334295.50403.4c","article-title":"Cross-sensitivity of skin rashes with antiepileptic drug use","volume":"71","author":"Hirsch","year":"2008","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.seizure.2010.09.003_bib0090","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1600-0404.1993.tb04106.x","article-title":"Therapeutic experiences with 947 epileptic out-patients in oxcarbazepine treatment","volume":"87","author":"Friis","year":"1993","journal-title":"Acta Neurol Scand"},{"issue":"6","key":"10.1016\/j.seizure.2010.09.003_bib0095","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1006\/ebeh.2000.0126","article-title":"Oxcarbazepine for treatment of partial epilepsy: a review and recommendations for clinical use","volume":"1","author":"Schmidt","year":"2000","journal-title":"Epilepsy Behav"},{"issue":"1\u20132","key":"10.1016\/j.seizure.2010.09.003_bib0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0300-483X(00)00397-8","article-title":"Metabolic activation in drug allergies","volume":"158","author":"Park","year":"2001","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.seizure.2010.09.003_bib0105","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaci.2006.12.617","article-title":"Generation and characterization of antigen-specific CD4+, CD8+, and CD4+ CD8+ T-cell clones from patients with carbamazepine hypersensitivity","volume":"119","author":"Wu","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"10.1016\/j.seizure.2010.09.003_bib0110","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.4049\/jimmunol.168.10.5359","article-title":"Characterization of drug-specific T cells in phenobarbital-induced eruption","volume":"168","author":"Hashizume","year":"2002","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.seizure.2010.09.003_bib0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2332\/allergolint.55.27","article-title":"Immune mechanisms in drugs allergy","volume":"55","author":"Roujeau","year":"2006","journal-title":"Allergol Int"},{"issue":"6982","key":"10.1016\/j.seizure.2010.09.003_bib0120","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens\u2013Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.seizure.2010.09.003_bib0125","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1067\/mai.2003.1507","article-title":"Characterization of drug-specific T cells in lamotrigine hypersensitivity","volume":"111","author":"Naisbitt","year":"2003","journal-title":"J Allerty Clin Immunol"},{"issue":"26","key":"10.1016\/j.seizure.2010.09.003_bib0130","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.2174\/138161206778193962","article-title":"Hypersensitivity to aromatic anticonvulsants: in vivo and in vitro cross-reactibity studies","volume":"12","author":"Romano","year":"2006","journal-title":"Curr Pharm Des"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131110002049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131110002049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:38:39Z","timestamp":1761010719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131110002049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S1059131110002049"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2010.09.003","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2010.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}