{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:09:57Z","timestamp":1788023397936,"version":"build-2784847793"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":838,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.seizure.2010.11.019","type":"journal-article","created":{"date-parts":[[2010,12,19]],"date-time":"2010-12-19T04:06:18Z","timestamp":1292731578000},"page":"203-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of chronic treatment with valproate and oxcarbazepine on testicular development in rats"],"prefix":"10.1016","volume":"20","author":[{"given":"Ali","family":"Cansu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Ekinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Serdaroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seren Gulsen","family":"G\u00fcrgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zalp","family":"Ekinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Erdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer Kutay","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfi","family":"Tunc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2010.11.019_bib0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0140-6736(00)02515-0","article-title":"Management of epilepsy in adolescents and adults","volume":"356","author":"Brodie","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.seizure.2010.11.019_bib0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2165\/00003495-199651030-00005","article-title":"Diagnosis and treatment of epilepsy in children and adolescents","volume":"51","author":"Morton","year":"1996","journal-title":"Drugs"},{"key":"10.1016\/j.seizure.2010.11.019_bib0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eplepsyres.2009.09.008","article-title":"Antiepileptic drugs and hormones in children","volume":"89","author":"Cansu","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2010.11.019_bib0020","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/jnnp.45.9.844","article-title":"The effect of anticonvulsant drugs on the development of male rats and their fertility","volume":"45","author":"Cohn","year":"1982","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.seizure.2010.11.019_bib0025","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0300-483X(90)90038-I","article-title":"Preclinical toxicology of the anticonvulsant calcium valproate","volume":"63","author":"Walker","year":"1990","journal-title":"Toxicology"},{"key":"10.1016\/j.seizure.2010.11.019_bib0030","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1528-1157.1978.tb05034.x","article-title":"Excretion of valproic acid into semen of rabbits and man","volume":"19","author":"Swanson","year":"1978","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2010.11.019_bib0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2131\/jts.25.85","article-title":"Effects of valproic acid on fertility and reproductive organs in male rats","volume":"25","author":"Nishimura","year":"2000","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.seizure.2010.11.019_bib0040","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1212\/01.WNL.0000098936.46730.64","article-title":"Effect of epilepsy and antiepileptic drugs on male reproductive health","volume":"62","author":"Isoj\u00e4rvi","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2010.11.019_bib0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/seiz.2001.0545","article-title":"Morphological changes in the testis after long-term valproate treatment in male Wistar rats","volume":"10","author":"R\u00f8ste","year":"2001","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2010.11.019_bib0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2165\/00148581-200608020-00004","article-title":"Valproate as a mainstay of therapy for pediatric epilepsy","volume":"8","author":"Guerrini","year":"2006","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.seizure.2010.11.019_bib0055","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2165\/00148581-200305080-00006","article-title":"Oxcarbazepine: a review of its use in children with epilepsy","volume":"5","author":"Bang","year":"2003","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.seizure.2010.11.019_bib0060","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF00196862","article-title":"Serum sex hormone levels after replacing carbamazepine with oxcarbazepine","volume":"47","author":"Isoj\u00e4rvi","year":"1995","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.seizure.2010.11.019_bib0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1212\/WNL.56.1.31","article-title":"Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy","volume":"56","author":"R\u00e4tty\u00e4","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2010.11.019_bib0070","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.seizure.2007.11.008","article-title":"Disorders of reproduction in epilepsy\u2014what can we learn from animal studies?","volume":"17","author":"Taub\u00f8ll","year":"2008","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2010.11.019_bib0075","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0890-6238(02)00054-0","article-title":"Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats","volume":"16","author":"R\u00f8ste","year":"2002","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.seizure.2010.11.019_bib0080","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/j.1528-1157.1999.tb00918.x","article-title":"Oxcarbazepine","volume":"40","author":"Tecoma","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2010.11.019_bib0085","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2131\/jts.20.4_407","article-title":"Morphological evaluation of cyclophosphamide testicular toxicity in rats using quantitative morphometry of spermatogenic cycle stages","volume":"20","author":"Matsui","year":"1995","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.seizure.2010.11.019_bib0090","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1152\/physrev.1972.52.1.198","article-title":"Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal","volume":"52","author":"Clermont","year":"1972","journal-title":"Physiol Rev"},{"key":"10.1016\/j.seizure.2010.11.019_bib0095","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1095\/biolreprod43.3.525","article-title":"Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic embedded testes","volume":"43","author":"Hess","year":"1990","journal-title":"Biol Reprod"},{"key":"10.1016\/j.seizure.2010.11.019_bib0100","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1749-6632.1952.tb26576.x","article-title":"Definition of the stages of the cycle of the seminiferous epithelium in the rat","volume":"55","author":"Leblond","year":"1952","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.seizure.2010.11.019_bib0105","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0014-4800(85)90069-3","article-title":"A quantitative study of stage-specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat","volume":"43","author":"Creasy","year":"1985","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.seizure.2010.11.019_bib0110","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/0272-0590(86)90176-4","article-title":"Use of quantitative testicular histopathology to assess the effects of DBCP on reproduction in rabbits","volume":"6","author":"Foote","year":"1986","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.seizure.2010.11.019_bib0115","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0890-6238(01)00149-6","article-title":"Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene","volume":"15","author":"Revel","year":"2001","journal-title":"Reprod Toxicol"},{"issue":"July (7)","key":"10.1016\/j.seizure.2010.11.019_bib0120","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.0013-9580.2004.04604.x","article-title":"Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy","volume":"45","author":"Mikkonen","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2010.11.019_bib0125","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1528-1167.2008.01576.x","article-title":"Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats","volume":"49","author":"Cansu","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2010.11.019_bib0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1528-1167.2009.02259.x","article-title":"Histologic and morphologic effects of valproic acid and oxcarbazepine on rat uterine and ovarian cells","volume":"51","author":"Cansu","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2010.11.019_bib0135","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0955-0674(98)80109-9","article-title":"Spermatogonial stem cells","volume":"10","author":"de Rooij","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.seizure.2010.11.019_bib0140","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s007950100018","article-title":"Male germ cell death in mouse testes: possible involvement of Fas and Fas ligand","volume":"34","author":"Koji","year":"2001","journal-title":"Med Electron Microsc"},{"key":"10.1016\/j.seizure.2010.11.019_bib0145","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/j.1528-1167.2009.02131.x","article-title":"Effects of levetiracetam and valproate on reproductive endocrine function studied in human ovarian follicular cells","volume":"50","author":"Taub\u00f8ll","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2010.11.019_bib0150","first-page":"771","article-title":"Antiapoptotic action of lithium and valproate","volume":"60","author":"Bielecka","year":"2008","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.seizure.2010.11.019_bib0155","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.seizure.2009.02.003","article-title":"Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat","volume":"18","author":"Akta\u015f","year":"2009","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2010.11.019_bib0160","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.0013-9580.2004.14104.x","article-title":"Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093","volume":"45","author":"Ara\u00fajo","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2010.11.019_bib0165","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/362849a0","article-title":"Thymocyte apoptosis induced by p53-dependent and independent pathways","volume":"362","author":"Clarke","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.seizure.2010.11.019_bib0170","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/jncimonographs\/lgi006","article-title":"Mechanisms of toxic damage to spermatogenesis","author":"Boekelheide","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.seizure.2010.11.019_bib0175","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/S0022-5347(01)64915-2","article-title":"Temperature-mediated germ cell loss in the testis is associated with altered expression of the cell-cycle regulator p53","volume":"157","author":"Socher","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.seizure.2010.11.019_bib0180","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1095\/biolreprod48.1.40","article-title":"Localization of transforming growth factor beta 1 and beta 2 during testicular development in the rat","volume":"48","author":"Teerds","year":"1993","journal-title":"Biol Reprod"},{"key":"10.1016\/j.seizure.2010.11.019_bib0185","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1210\/endo.133.4.8404607","article-title":"Effects of activin-A, inhibin-A, and transforming growth factor-beta 1 on stage-specific deoxyribonucleic acid synthesis during rat seminiferous epithelial cycle","volume":"133","author":"Hakovirta","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.seizure.2010.11.019_bib0190","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/(SICI)1098-2795(199904)52:4<341::AID-MRD2>3.0.CO;2-N","article-title":"Strain dependency of TGF-\u03b21 function during embryogenesis","volume":"52","author":"Kallapur","year":"1999","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.seizure.2010.11.019_bib0195","first-page":"105","article-title":"Stage-specific localization of transforming growth factor beta1 and beta3 and their receptors during spermatogenesis in men","volume":"6","author":"Zhang","year":"2004","journal-title":"Asian J Androl"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105913111000302X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105913111000302X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:40:06Z","timestamp":1761010806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105913111000302X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S105913111000302X"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2010.11.019","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of chronic treatment with valproate and oxcarbazepine on testicular development in rats","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2010.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}