{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:10:07Z","timestamp":1761513007540,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":624,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.seizure.2011.06.022","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T22:35:23Z","timestamp":1311460523000},"page":"701-705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["An open-label, add-on study of pregabalin in patients with partial seizures: A multicenter trial in Greece"],"prefix":"10.1016","volume":"20","author":[{"given":"Stefanos","family":"Tsounis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilios K.","family":"Kimiskidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kazis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Gkiatas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriakos","family":"Garganis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klimentini","family":"Karageorgiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stylianos","family":"Giannakodimos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Papathanasopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Plaitakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonidas","family":"Lyras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birol","family":"Emir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2011.06.022_bib0005","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1528-1157.1997.tb01224.x","article-title":"Commission on European affairs: appropriate standards of epilepsy care across Europe: ILEA","volume":"38","author":"Brodie","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0010","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJM200002033420503","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Kwan","year":"2000","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.seizure.2011.06.022_bib0015","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0140-6736(95)91208-8","article-title":"Remission of epilepsy: results from the National General Practice Study of Epilepsy","volume":"346","author":"Cockerell","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.seizure.2011.06.022_bib0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.eplepsyres.2006.09.008","article-title":"Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery","volume":"73","author":"Taylor","year":"2007","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.seizure.2011.06.022_bib0025","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pain.2005.02.032","article-title":"Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens","volume":"115","author":"Freynhagen","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.seizure.2011.06.022_bib0030","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1212\/01.wnl.0000244422.45278.ff","article-title":"Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial","volume":"67","author":"Siddall","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2011.06.022_bib0035","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4088\/JCP.v67n0511","article-title":"Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo controlled comparison of pregabalin and venlafaxine","volume":"67","author":"Montgomery","year":"2006","journal-title":"The Journal of Clinical Psychiatry"},{"issue":"Suppl. 6","key":"10.1016\/j.seizure.2011.06.022_bib0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0013-9580.2004.455003.x","article-title":"Pregabalin pharmacology and its relevance to clinical practice","volume":"45","author":"Ben-Menachem","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0045","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1528-1167.2005.19204.x","article-title":"Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy","volume":"46","author":"Brodie","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.0013-9580.2004.31203.x","article-title":"Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose\u2013response study in adults with partial seizures","volume":"45","author":"Arroyo","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0055","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1212\/01.WNL.0000150932.48688.BE","article-title":"Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy","volume":"64","author":"Beydoun","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2011.06.022_bib0060","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1212\/01.WNL.0000068024.20285.65","article-title":"Dose\u2013response trial of pregabalin adjunctive therapy in patients with partial seizures","volume":"60","author":"French","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2011.06.022_bib0065","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/j.1528-1167.2005.00341.x","article-title":"Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study","volume":"46","author":"Elger","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0920-1211(01)00216-9","article-title":"Proof of efficacy trials: endpoints","volume":"45","author":"French","year":"2001","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.seizure.2011.06.022_bib0075","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety and Depression Scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatrica Scandinavica"},{"year":"1976","series-title":"ECDEU assessment manual for psychopharmacology","author":"Guy","key":"10.1016\/j.seizure.2011.06.022_bib0080"},{"issue":"Suppl. 5","key":"10.1016\/j.seizure.2011.06.022_bib0085","first-page":"S9","article-title":"Optimizing health outcomes in active epilepsy","volume":"58","author":"Gilliam","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2011.06.022_bib0090","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yebeh.2008.02.006","article-title":"Strategies to detect adverse effects of antiepileptic drugs in clinical practice","volume":"13","author":"Carreno","year":"2008","journal-title":"Epilepsy & Behavior"},{"key":"10.1016\/j.seizure.2011.06.022_bib0095","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1528-1157.1996.tb00006.x","article-title":"The clinical course of epilepsy and its psychosocial correlates: findings from a U.K. community study","volume":"37","author":"Jacoby","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0100","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1528-1157.1998.tb01427.x","article-title":"Symptoms of depression and anxiety in pediatric epilepsy patients","volume":"39","author":"Ettinger","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0105","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1176\/jnp.17.2.172","article-title":"Clinical assessment of Axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation","volume":"17","author":"Jones","year":"2005","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"10.1016\/j.seizure.2011.06.022_bib0110","first-page":"428","article-title":"Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea","volume":"108","author":"Choi-Kwon","year":"2003","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1016\/j.seizure.2011.06.022_bib0115","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.0013-9580.2004.47003.x","article-title":"The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy","volume":"45","author":"Johnson","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0120","series-title":"Epilepsy 2001. From science to patient","first-page":"257","article-title":"Psychiatric disorder in epilepsy","author":"Betts","year":"2001"},{"key":"10.1016\/j.seizure.2011.06.022_bib0125","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2147\/NDT.S4716","article-title":"Pregabalin for the management of partial epilepsy","volume":"4","author":"Ryvlin","year":"2008","journal-title":"Neuropsychiatric Disease and Treatment"},{"issue":"January 25","key":"10.1016\/j.seizure.2011.06.022_bib0130","article-title":"Pregabalin in partial seizures: a pragmatic 21-week, open-label study (PREPS)","author":"Ryvlin","year":"2010","journal-title":"European Journal of Neurology"},{"key":"10.1016\/j.seizure.2011.06.022_bib0135","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1111\/j.1528-1167.2009.02148.x","article-title":"Rapid onset of seizure suppression with pregabalin adjunctive treatment in patients with partial seizures","volume":"50","author":"Ramsay","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0140","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1528-1167.2008.01954.x","article-title":"Pregabalin add-on therapy using a flexible, optimized dose schedule in refractory partial epilepsies: a double-blind, randomized, placebo-controlled, multicenter trial","volume":"50","author":"Lee","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.06.022_bib0145","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.seizure.2009.01.001","article-title":"Pregabalin as adjunctive therapy for partial epilepsy: an audit study in 96 patients from the South East of England","volume":"18","author":"Valentin","year":"2009","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2011.06.022_bib0150","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.seizure.2007.05.011","article-title":"Pregabalin as add-on therapy for refractory partial seizures in every day clinical practice","volume":"16","author":"Carre\u00f1o","year":"2007","journal-title":"Seizure"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131111001816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131111001816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:40:37Z","timestamp":1761010837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131111001816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S1059131111001816"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2011.06.022","relation":{},"ISSN":["1059-1311"],"issn-type":[{"type":"print","value":"1059-1311"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An open-label, add-on study of pregabalin in patients with partial seizures: A multicenter trial in Greece","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2011.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}