{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:22:18Z","timestamp":1761016938384,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":472,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007033","name":"Eisai Korea Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007033","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.seizure.2011.12.005","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T12:54:35Z","timestamp":1325768075000},"page":"188-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean patients"],"prefix":"10.1016","volume":"21","author":[{"given":"Kyoung","family":"Heo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung In","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Do","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Won","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Jin","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Ki","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Pa","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu-Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2011.12.005_bib0005","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.seizure.2011.12.005_bib0010","series-title":"Antiepileptic Drugs","first-page":"873","article-title":"Zonisamide. Chemistry, biotransformation, and pharmacokinetics","author":"Shah","year":"2002"},{"key":"10.1016\/j.seizure.2011.12.005_bib0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/j.1552-4604.1998.tb04406.x","article-title":"Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures","volume":"38","author":"Kochak","year":"1998","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.seizure.2011.12.005_bib0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00007691-199812000-00001","article-title":"Clinical pharmacology and therapeutic drug monitoring of zonisamide","volume":"20","author":"Mimaki","year":"1998","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.seizure.2011.12.005_bib0025","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1528-1167.2007.00983.x","article-title":"Pharmacokinetics and drug interactions with zonisamide","volume":"48","author":"Sills","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.12.005_bib0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0920-1211(93)90011-U","article-title":"Zonisamide for add-on treatment of refractory partial epilepsy: a European double-blind trial","volume":"15","author":"Schmidt","year":"1993","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2011.12.005_bib0035","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1212\/WNL.57.10.1774","article-title":"Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures","volume":"57","author":"Faught","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2011.12.005_bib0040","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.0013-9580.2004.11403.x","article-title":"Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures","volume":"45","author":"Sackellares","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.12.005_bib0045","first-page":"31","article-title":"Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures","volume":"46","author":"Brodie","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.12.005_bib0050","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0920-1211(93)90021-X","article-title":"Efficacy and safety of zonisamide: results of a multicenter study","volume":"14","author":"Leppik","year":"1993","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2011.12.005_bib0055","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.yebeh.2006.02.001","article-title":"Long-term efficacy and safety of monotherapy and adjunctive therapy with zonisamide","volume":"8","author":"Tosches","year":"2006","journal-title":"Epilepsy Behav"},{"issue":"Suppl 2","key":"10.1016\/j.seizure.2011.12.005_bib0060","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.eplepsyres.2005.11.006","article-title":"Practical prescribing and long-term efficacy and safety of zonisamide","volume":"68","author":"Leppik","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2011.12.005_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0404.2008.01055.x","article-title":"Long-term safety and efficacy of zonisamide in patients with refractory partial-onset epilepsy","volume":"118","author":"Wroe","year":"2008","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.seizure.2011.12.005_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejpn.2008.01.004","article-title":"Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy","volume":"13","author":"Shinnar","year":"2009","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.seizure.2011.12.005_bib0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.eplepsyres.2008.10.012","article-title":"Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study","volume":"83","author":"Coppola","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2011.12.005_bib0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/01.wnf.0000159956.87511.67","article-title":"Meta-analysis and indirect comparisons of levetiracetam with other second-generation antiepileptic drugs in partial epilepsy","volume":"28","author":"Otoul","year":"2005","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.seizure.2011.12.005_bib0085","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1586\/14737175.8.7.1013","article-title":"Efficacy and tolerability of pregabalin in partial epilepsy","volume":"8","author":"Beydoun","year":"2008","journal-title":"Expert Rev Neurotherap"},{"key":"10.1016\/j.seizure.2011.12.005_bib0090","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","article-title":"Proposal for revised clinical and electroencephalographic classification of epileptic seizure","volume":"22","author":"Commission on Classification and Terminology of the International League Against Epilepsy","year":"1981","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.12.005_bib0095","first-page":"45","article-title":"The reliability and validity of Korean QOLIE-31 in patients with epilepsy","volume":"6","author":"Yoo","year":"2002","journal-title":"J Kor Epilepsy Soc"},{"key":"10.1016\/j.seizure.2011.12.005_bib0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1528-1157.1998.tb01278.x","article-title":"Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory","volume":"39","author":"Cramer","year":"1998","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.seizure.2011.12.005_bib0105","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.eplepsyres.2005.11.005","article-title":"Zonisamide as adjunctive therapy for refractory partial seizures","volume":"68","author":"Brodie","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2011.12.005_bib0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.eplepsyres.2008.03.024","article-title":"Overwhelming heterogeneity in systematic reviews of observational anti-epileptic studies","volume":"80","author":"Maguire","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2011.12.005_bib0115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-0404.2009.01311.x","article-title":"Flexible dosing of adjunctive zonisamide in the treatment of adult partial-onset seizures: a non-comparative, open-label study (ZEUS)","volume":"121","author":"Dupont","year":"2010","journal-title":"Acta Neurol Scand"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131111003177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131111003177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:41:33Z","timestamp":1761010893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131111003177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1059131111003177"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2011.12.005","relation":{},"ISSN":["1059-1311"],"issn-type":[{"type":"print","value":"1059-1311"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean patients","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2011.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}