{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:21:51Z","timestamp":1765545711975,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":472,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.seizure.2011.12.013","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T04:44:03Z","timestamp":1326689043000},"page":"229-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Carbamazepine-induced hypogammaglobulinemia"],"prefix":"10.1016","volume":"21","author":[{"given":"Nihal","family":"Ozaras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadir","family":"Goksugur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saliha","family":"Eroglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omur","family":"Tabak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billur","family":"Canbakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Resat","family":"Ozaras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2011.12.013_bib0005","unstructured":"Carbamazepine. Drug information. Uptodate Online 18.3."},{"issue":"Suppl. 1","key":"10.1016\/j.seizure.2011.12.013_bib0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hup.917","article-title":"Haematological toxicity of drugs used in psychiatry","volume":"23","author":"Flanagan","year":"2008","journal-title":"Human Psychopharmacology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1590\/S0041-87812001000600006","article-title":"Secondary hypogammaglobulinemia after use of carbamazepine: case report and review","volume":"56","author":"Castro","year":"2001","journal-title":"Revista do Hospital das Clinicas"},{"key":"10.1016\/j.seizure.2011.12.013_bib0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0953-6205(01)00111-X","article-title":"Visceral leishmaniasis in a patient with acquired hypogammaglobulinemia","volume":"12","author":"Voutsinas","year":"2001","journal-title":"European Journal of Internal Medicine"},{"key":"10.1016\/j.seizure.2011.12.013_bib0025","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/thx.2006.063842","article-title":"Secondary bronchiolitis obliterans organising pneumonia in a patient with carbamazepine-induced hypogammaglobulinemia","volume":"62","author":"Tamada","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.seizure.2011.12.013_bib0030","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1136\/jnnp.2006.090266","article-title":"Recurrent herpes simplex virus encephalitis secondary to carbamazepine induced hypogammaglobulinemia","volume":"78","author":"Rice","year":"2007","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1016\/j.seizure.2011.12.013_bib0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1365-2133.2003.05368.x","article-title":"Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction","volume":"149","author":"Aihara","year":"2003","journal-title":"British Journal of Dermatology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0300-2977(98)00140-5","article-title":"A man with a mysterious hypogammaglobulinemia and skin rash","volume":"54","author":"van Ginneken","year":"1999","journal-title":"The Netherlands Journal of Medicine"},{"key":"10.1016\/j.seizure.2011.12.013_bib0045","first-page":"273","article-title":"Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro","volume":"20","author":"Sorrell","year":"1975","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0050","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/jnnp.60.4.459","article-title":"Hypogammaglobulinemia with absent B lymphocytes and agranulocytosis after carbamazepine treatment","volume":"60","author":"Spickett","year":"1996","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1016\/j.seizure.2011.12.013_bib0055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/096032718500400205","article-title":"Effect of chronic anticonvulsant monotherapy on lymphocyte subpopulations in adult epileptic patients","volume":"4","author":"Marcoli","year":"1985","journal-title":"Human Toxicology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0060","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0192-0561(83)90030-9","article-title":"The in vitro effect of phenytoin and carbamazepine on subpopulations of human blood mononuclear cells","volume":"5","author":"Gilhus","year":"1983","journal-title":"International Journal of Immunopharmacology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-0404.1986.tb07852.x","article-title":"Carbamazepine effects on mononuclear blood cells in epileptic patients","volume":"74","author":"Gilhus","year":"1986","journal-title":"Acta Neurologica Scandinavica"},{"key":"10.1016\/j.seizure.2011.12.013_bib0070","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1528-1157.1988.tb03726.x","article-title":"Carbamazepine: effect on IgG subclasses in epileptic patients","volume":"29","author":"Gilhus","year":"1988","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2011.12.013_bib0075","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0192-0561(94)90087-6","article-title":"Humoral and cellular immune parameters in untreated and phenytoin-or carbamazepine-treated epileptic patients","volume":"16","author":"Basaran","year":"1994","journal-title":"International Journal of Immunopharmacology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0080","first-page":"55","article-title":"Transient hypogammaglobulinemia in the adult. Functional assessment of T and B lymphocytes","volume":"11","author":"Garcia Rodriguez","year":"1983","journal-title":"Journal of Clinical & Laboratory Immunology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0085","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1059-1311(03)00086-4","article-title":"Carbamazepine-induced IgG1 and IgG2 deficiency associated with B cell maturation defect","volume":"13","author":"Go","year":"2004","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2011.12.013_bib0090","first-page":"496","article-title":"Thrombocytopenia associated with carbamazepine: a case series","volume":"52","author":"Tohen","year":"1991","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.seizure.2011.12.013_bib0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/(SICI)1096-8652(199909)62:1<52::AID-AJH9>3.0.CO;2-E","article-title":"Carbamazepine-induced thrombocytopenia defined by a challenge test","volume":"62","author":"Ishikita","year":"1999","journal-title":"American Journal of Hematology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000206952","article-title":"IgG antiplatelet antibodies due to carbamazepine","volume":"68","author":"Kornberg","year":"1982","journal-title":"Acta Haematologica"},{"key":"10.1016\/j.seizure.2011.12.013_bib0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00313318","article-title":"The reversibility of phenytoin-induced IgA deficiency","volume":"226","author":"Gilhus","year":"1981","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.seizure.2011.12.013_bib0110","series-title":"Intravenous immunoglubulin in clinical practice","first-page":"175","article-title":"Treatment of primary immunodeficiency diseases with gammaglobulin","author":"Schuff","year":"1997"},{"key":"10.1016\/j.seizure.2011.12.013_bib0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.semarthrit.2008.05.002","article-title":"Serum immunoglobulins and risk of infection: how low can you go?","volume":"39","author":"Furst","year":"2009","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"10.1016\/j.seizure.2011.12.013_bib0120","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2169\/internalmedicine.49.3087","article-title":"B cell aplasia and hypogammaglobulinemia after carbamazepine treatment","volume":"49","author":"Yamamoto","year":"2010","journal-title":"Internal Medicine"},{"key":"10.1016\/j.seizure.2011.12.013_bib0125","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.4065\/72.12.1145","article-title":"Lupus and pulmonary nodules consistent with bronchiolitis obliterans organising pneumonia induced by carbamazepine","volume":"72","author":"Milesi-Lecat","year":"1997","journal-title":"Mayo Clinic Proceedings"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131111003256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131111003256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:41:26Z","timestamp":1761010886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131111003256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1059131111003256"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2011.12.013","relation":{},"ISSN":["1059-1311"],"issn-type":[{"type":"print","value":"1059-1311"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbamazepine-induced hypogammaglobulinemia","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2011.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}