{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:11:54Z","timestamp":1785222714597,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.seizure.2013.09.016","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:17:03Z","timestamp":1381191423000},"page":"98-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Landau\u2013Kleffner syndrome: A study of 29 patients"],"prefix":"10.1016","volume":"23","author":[{"given":"Roberto Horacio","family":"Caraballo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cejas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Chamorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda C.","family":"Kaltenmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Fortini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Soprano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2013.09.016_bib0005","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1212\/WNL.7.8.523","article-title":"Syndrome of acquired aphasia with convulsive disorder in children","volume":"7","author":"Landau","year":"1957","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2013.09.016_bib0010","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1469-8749.1988.tb04811.x","article-title":"Verbal auditory agnosia in children","volume":"30","author":"Rapin","year":"1988","journal-title":"Dev Med Child Neurol"},{"issue":"4","key":"10.1016\/j.seizure.2013.09.016_bib0015","doi-asserted-by":"crossref","first-page":"380","DOI":"10.33588\/rn.2904.99107","article-title":"El s\u00edndrome de Landau Kleffner","volume":"29","author":"Aicardi","year":"1999","journal-title":"Rev Neurol"},{"issue":"10","key":"10.1016\/j.seizure.2013.09.016_bib0020","doi-asserted-by":"crossref","first-page":"899","DOI":"10.33588\/rn.2910.99150","article-title":"Afasia epil\u00e8ptica adquirida","volume":"29","author":"Caraballo","year":"1999","journal-title":"Rev Neurol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0387-7604(93)90035-7","article-title":"Developmental dysphasias, epilepsy and Landau\u2013Kleffner syndrome","volume":"15","author":"De Negri","year":"1993","journal-title":"Brain Dev"},{"key":"10.1016\/j.seizure.2013.09.016_bib0030","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00004691-199107010-00005","article-title":"Acquired epileptiform aphasia in children (Landau\u2013Kleffner syndrome)","volume":"8","author":"Deonna","year":"1991","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0035","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.braindev.2010.06.011","article-title":"Early-onset acquired epileptic aphasia (Landau\u2013Kleffner syndrome LKS) and regressive autistic disorders with epileptic EEG abnormalities: the continuing debate","volume":"32","author":"Deonna","year":"2009","journal-title":"Brain Dev"},{"key":"10.1016\/j.seizure.2013.09.016_bib0040","first-page":"739","article-title":"Sign language in childhood epileptic aphasia (Landau\u2013Kleffner syndrome)","volume":"43","author":"Perez","year":"2001","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0028-1091522","article-title":"Acquired aphasia in childhood with seizure disorder: a heterogeneous syndrome","volume":"8","author":"Deonna","year":"1977","journal-title":"Neuropadiatrie"},{"issue":"6","key":"10.1016\/j.seizure.2013.09.016_bib0050","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/13854046.2011.614779","article-title":"Changing perspectives on Landau\u2013Kleffner syndrome","volume":"25","author":"Stefanatos","year":"2011","journal-title":"Clin Neuropsychol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0055","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0887-8994(92)90302-F","article-title":"Neuropsychological and neurolinguistic aspect in a group of patients with acquired epileptic aphasia or Landau\u2013Kleffner syndrome","volume":"8","author":"Soprano","year":"1992","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0060","series-title":"Epileptic syndromes in infancy. Childhood and adolescence","first-page":"255","article-title":"Encephalopathy related to status epilepticus during slow sleep (ESES) including Landau\u2013Kleffner syndrome","author":"Tassinari","year":"2012"},{"key":"10.1016\/j.seizure.2013.09.016_bib0065","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1528-1157.1993.tb02595.x","article-title":"Intracranial EEG monitoring in Landau\u2013Kleffner syndrome associated with left temporal lobe astrocytoma","volume":"34","author":"Solomon","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2013.09.016_bib0070","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1212\/01.WNL.0000160386.79347.4A","article-title":"Perisylvian polymicrogyria in Landau\u2013Kleffner syndrome","volume":"64","author":"Huppke","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2013.09.016_bib0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1528-1157.2000.tb00177.x","article-title":"Atypical evolutions of benign localization-related epilepsies in children: are they predictable?","volume":"41","author":"Fejerman","year":"2000","journal-title":"Epilepsia"},{"issue":"1\u20132","key":"10.1016\/j.seizure.2013.09.016_bib0080","first-page":"64","article-title":"Encephalopathy with status epilepticus during sleep or continuous spikes and waves during slow sleep syndrome: a multicenter, long-term follow-up study of 117 patients","volume":"105","author":"Caraballo","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2013.09.016_bib0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2165\/00148581-200507060-00006","article-title":"Management of Landau\u2013Kleffner syndrome","volume":"7","author":"Mikati","year":"2005","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.seizure.2013.09.016_bib0090","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1528-1157.1990.tb05518.x","article-title":"Landau\u2013Kleffner syndrome: a pharmacologic study of five cases","volume":"31","author":"Marescaux","year":"1990","journal-title":"Epilepsia"},{"issue":"suppl 7","key":"10.1016\/j.seizure.2013.09.016_bib0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1528-1167.2009.02221.x","article-title":"Landau\u2013Kleffner syndrome and CSWS syndrome: treatment with intravenous immunoglobulin","volume":"50","author":"Arts","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2013.09.016_bib0100","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S1525-5050(03)00080-5","article-title":"The effects of vagus nerve stimulation therapy on patients with intractable seizures and either Landau\u2013Kleffner syndrome or autism","volume":"4","author":"Park","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2013.09.016_bib0105","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/brain\/118.6.1529","article-title":"Landau\u2013Kleffner syndrome syndrome. Treatment with subpial intracortical transection","volume":"118","author":"Morrell","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.seizure.2013.09.016_bib0110","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1046\/j.1528-1157.2001.10401.x","article-title":"A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE task force on classification and terminology","volume":"42","author":"Engel","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2013.09.016_bib0115","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1111\/j.1528-1167.2006.00215.x","article-title":"Report of the ILAE classification core group","volume":"47","author":"Engel","year":"2006","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.seizure.2013.09.016_bib0120","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005\u20132009","volume":"51","author":"Berg","year":"2010","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.seizure.2013.09.016_bib0125","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0387-7604(97)00058-2","article-title":"Electrical status epilepticus during sleep (ESES). Different clinical syndromes: towards a unifying view?","volume":"19","author":"De Negri","year":"1997","journal-title":"Brain Dev"},{"key":"10.1016\/j.seizure.2013.09.016_bib0130","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00004691-200311000-00008","article-title":"Epileptic encephalopathy of late childhood: Landau Kleffner syndrome and the syndrome of continuous spikes and waves during slow-waves sleep","volume":"20","author":"Smith","year":"2003","journal-title":"J Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.seizure.2013.09.016_bib0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yebeh.2010.10.015","article-title":"A review of the relationships between Landau\u2013Kleffner syndrome, electrical status epilepticus during sleep, and continuous spike-waves during sleep","volume":"20","author":"Hughes","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2013.09.016_bib0140","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1017\/S1355617798466050","article-title":"Neuropsychological characteristics of five children with the Landau\u2013Kleffner syndrome: dissociation of auditory and phonological discrimination","volume":"4","author":"Korkman","year":"1998","journal-title":"J Int Neuropsychol Soc"},{"key":"10.1016\/j.seizure.2013.09.016_bib0145","first-page":"349","article-title":"Autistic regression and Landau\u2013Kleffner syndrome: progress or confusion?","volume":"42","author":"Mantovani","year":"2000","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-2008-1071519","article-title":"Speech and oromotor deficits of epileptic origin in benign partial epilepsy of childhood with rolandic spikes (BPERS). Relationship to the acquired aphasia-epilepsy syndrome","volume":"24","author":"Deonna","year":"1993","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.seizure.2013.09.016_bib0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1528-1167.2006.00695.x","article-title":"Neuropsychological findings in Rolandic epilepsy and Landau\u2013Kleffner syndrome","volume":"47","author":"Metz-Lutz","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2013.09.016_bib0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yebeh.2012.12.025","article-title":"BECTS evolving to Landau\u2013Kleffner syndrome and back by subsequent recovery: a longitudinal language reorganization case study using fMRI, source EEG and neuropsychological testing","volume":"27","author":"Datta","year":"2013","journal-title":"Epilepsy Behav"},{"issue":"2","key":"10.1016\/j.seizure.2013.09.016_bib0165","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/epi.12065","article-title":"Clinical genetic study of the epilepsy-aphasia spectrum","volume":"54","author":"Tsai","year":"2013","journal-title":"Epylepsia"},{"issue":"7","key":"10.1016\/j.seizure.2013.09.016_bib0170","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1528-1167.2009.02214.x","article-title":"From rolandic epilepsy to continuous spike-and-waves during sleep and Landau Kleffner syndromes: insights into possible genetic factors","volume":"50","author":"Rudolf","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2013.09.016_bib0175","article-title":"GRIN2A mutations cause epilepsy-aphasia spectrum disorders","author":"Carwill","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.seizure.2013.09.016_bib0180","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/archneur.1992.00530280034019","article-title":"The Landau\u2013Kleffner syndrome or acquiered childhood aphasia with convulsive disorder: long-term follow-up of six children and a review of the recent literature","volume":"49","author":"Paquier","year":"1992","journal-title":"Arch Neurol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0387-7604(98)00071-0","article-title":"Landau\u2013Kleffner syndrome (LKS): long-term follow-up and links with electrical status epilepticus during sleep (ESES)","volume":"21","author":"Rossi","year":"1999","journal-title":"Brain Dev"},{"key":"10.1016\/j.seizure.2013.09.016_bib0190","first-page":"243","article-title":"Landau\u2013Kleffner syndrome: course and correlates with outcome","volume":"43","author":"Robinson","year":"2001","journal-title":"Dev Medicine and Child Neurol"},{"key":"10.1016\/j.seizure.2013.09.016_bib0195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.braindev.2008.09.007","article-title":"Landau\u2013Kleffner syndrome: long-term follow-up","volume":"31","author":"Duran","year":"2009","journal-title":"Brain Dev"},{"key":"10.1016\/j.seizure.2013.09.016_bib0200","series-title":"Continuous spikes and waves during slow sleep. Electrical status epilepticus during slow sleep","first-page":"p143","article-title":"Late onset acquired epileptic aphasia","author":"Dugas","year":"1995"},{"key":"10.1016\/j.seizure.2013.09.016_bib0205","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/WNP.0b013e31821213eb","article-title":"Continuous spike and waves during sleep and electrical status epilepticus in sleep","volume":"28","author":"Loddenkemper","year":"2011","journal-title":"J Clin Neurophysiol"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105913111300277X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105913111300277X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:43:27Z","timestamp":1761011007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105913111300277X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S105913111300277X"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2013.09.016","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Landau\u2013Kleffner syndrome: A study of 29 patients","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2013.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}