{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:07:44Z","timestamp":1790723264760,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.seizure.2016.06.001","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T19:55:39Z","timestamp":1468353339000},"page":"70-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Effects of levetiracetam monotherapy on sperm parameters and sex hormones: Data from newly diagnosed patients with epilepsy"],"prefix":"10.1016","volume":"41","author":[{"given":"Mustafa","family":"Ceylan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer Faruk","family":"Bayraktutan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R\u0131za","family":"Sonkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2016.06.001_bib0220","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","article-title":"Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)","volume":"46","author":"Fisher","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0225","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1528-1157.1986.tb03605.x","article-title":"Fertility in persons with epilepsy","volume":"27","author":"Webber","year":"1986","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0230","series-title":"Epilepsy: a comprehensive textbook","first-page":"2013","article-title":"Disorders of reproduction and fertility","author":"Herzog","year":"1997"},{"key":"10.1016\/j.seizure.2016.06.001_bib0235","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/jnnp.42.3.256","article-title":"Mental aspects of temporal lobe epilepsy. Follow-up of 74 patients after resection of a temporal lobe","volume":"42","author":"Jensen","year":"1979","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.seizure.2016.06.001_bib0240","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/archneur.1986.00520040035015","article-title":"Reproductive endocrine disorders in men with partial seizures of temporal lobe origin","volume":"43","author":"Herzog","year":"1986","journal-title":"Arch Neurol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0245","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1017\/S0033291700005651","article-title":"Hyposexuality and epilepsy: a community survey of hormonal and behavioural changes in male epileptics","volume":"19","author":"Toone","year":"1989","journal-title":"Psychol Med"},{"key":"10.1016\/j.seizure.2016.06.001_bib0250","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1528-1157.1991.tb04691.x","article-title":"Phenytoin-induced elevation of serum estradiol and reproductive dysfunction in men with epilepsy","volume":"32","author":"Herzog","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0255","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000119132","article-title":"Sex hormones, gonadotropins and prolactin in male epileptic subjects in remission: role of the epileptic syndrome and of antiepileptic drugs","volume":"30","author":"Murialdo","year":"1994","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.seizure.2016.06.001_bib0260","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1600-0773.1995.tb00164.x","article-title":"Effects of long-term antiapileptic therapy on the catabolism of testosterone","volume":"76","author":"Brunet","year":"1995","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0265","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1528-1157.1995.tb01011.x","article-title":"Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy","volume":"36","author":"Isoj\u00e4rvi","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0270","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1468-1331.2003.00615.x","article-title":"Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy","volume":"10","author":"R\u00f8ste","year":"2003","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0275","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1212\/01.wnl.0000178988.78039.40","article-title":"Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy","volume":"65","author":"Herzog","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2016.06.001_bib0280","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1212\/WNL.56.1.31","article-title":"Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy","volume":"56","author":"R\u00e4tty\u00e4","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2016.06.001_bib0285","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00002826-198506000-00006","article-title":"Effects of carbamazepine on prolactin secretion in normal subjects and in epileptic subjects","volume":"8","author":"Bonuccelli","year":"1985","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0290","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2265.1984.tb00071.x","article-title":"Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in epileptic patients receiving carbamazepine or phenytoin","volume":"20","author":"Dana-Haeri","year":"1984","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0295","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/archneur.1990.00530060082023","article-title":"Serum hormones in male epileptic patients receiving anticonvulsant medication","volume":"47","author":"Isoj\u00e4rvi","year":"1990","journal-title":"Arch Neurol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0300","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1677\/joe.0.1530307","article-title":"Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients","volume":"153","author":"Geisler","year":"1997","journal-title":"J Endocrinol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0305","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1528-1157.1988.tb03747.x","article-title":"Circulating hormones and pituitary responsiveness in young epileptic men receiving long term antiepileptic medication","volume":"29","author":"Macphee","year":"1988","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0310","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s40263-013-0063-0","article-title":"The long-term safety of antiepileptic drugs","volume":"27","author":"Gaitatzis","year":"2013","journal-title":"CNS Drugs"},{"key":"10.1016\/j.seizure.2016.06.001_bib0315","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/j.1528-1167.2006.00668.x","article-title":"Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells","volume":"47","author":"Taub\u00f8ll","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0320","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.seizure.2007.11.018","article-title":"Long-term levetiracetam treatment affects reproductive endocrine function in female Wistar rats","volume":"17","author":"Svalheim","year":"2008","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2016.06.001_bib0325","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1111\/j.1528-1167.2010.02732.x","article-title":"Effect of levetiracetam on testosterone levels in male patients","volume":"51","author":"Harden","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0330","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.jocn.2012.11.028","article-title":"Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy","volume":"20","author":"Xiaotian","year":"2013","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.seizure.2016.06.001_bib0335","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.yebeh.2005.08.026","article-title":"Reproductive and sexual dysfunction in men epilepsy","volume":"7","author":"Montouris","year":"2005","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2016.06.001_bib0340","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3949\/ccjm.71.Suppl_2.S19","article-title":"Reproductive disturbances in patients with epilepsy","volume":"71","author":"Morrell","year":"2004","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.seizure.2016.06.001_bib0345","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0920-1211(91)90025-B","article-title":"A prospective study of serum sex hormones during carbamazepine therapy","volume":"9","author":"Isoj\u00e4rvi","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2016.06.001_bib0350","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.yebeh.2009.07.033","article-title":"Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults","volume":"16","author":"Svalheim","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2016.06.001_bib0355","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1528-1157.1992.tb02298.x","article-title":"Effects of antiepileptic drugs on sperm motility of normal controls and epileptic patients with long-term therapy","volume":"33","author":"Chen","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2016.06.001_bib0360","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/096032719501400703","article-title":"A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man","volume":"14","author":"Prentice","year":"1995","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0365","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/seiz.2001.0545","article-title":"Morphological changes in the testis after long-term valproate treatment in male Wistar rats","volume":"10","author":"R\u00f8ste","year":"2001","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2016.06.001_bib0370","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/1756285608094212","article-title":"Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited","volume":"1","author":"Surges","year":"2008","journal-title":"Ther Adv Neurol Disord"},{"key":"10.1016\/j.seizure.2016.06.001_bib0375","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s11033-008-9337-x","article-title":"Utilization of an intron located polyadenlyation site resulted in four novel glutamate decarboxylase transcripts","volume":"36","author":"Liu","year":"2009","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.seizure.2016.06.001_bib0380","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1745-7270.2008.00453.x","article-title":"Identification and expression of GABAC receptor in rat testis and spermatozoa","volume":"40","author":"Li","year":"2008","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.seizure.2016.06.001_bib0385","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/sj.cr.7290035","article-title":"Identification of gamma-aminobutyric acid transporter (GAT1) on the rat sperm","volume":"10","author":"Hu","year":"2000","journal-title":"Cell Res"},{"key":"10.1016\/j.seizure.2016.06.001_bib0390","first-page":"1229","article-title":"The cellular expression of GABA (A) receptor alpha1 subunit during spermatogenesis in the mouse testis","volume":"25","author":"Kanbara","year":"2010","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0395","first-page":"95","article-title":"Expression of the GABAA receptor\/chloride channel in murine spermatogenic cells","volume":"26","author":"Kanbara","year":"2011","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0400","first-page":"149","article-title":"GABA exists as a negative regulator of cell proliferation in spermatogonial stem cells","volume":"18","author":"Du","year":"2013","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.seizure.2016.06.001_bib0405","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1083\/jcb.100.4.1284","article-title":"Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells","volume":"100","author":"Buckley","year":"1985","journal-title":"J Cell Biol"},{"key":"10.1016\/j.seizure.2016.06.001_bib0410","doi-asserted-by":"crossref","first-page":"15268","DOI":"10.1073\/pnas.96.26.15268","article-title":"Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)","volume":"96","author":"Crowder","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.seizure.2016.06.001_bib0415","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1523\/JNEUROSCI.2699-05.2006","article-title":"Synaptic vesicle protein 2 enhances release probability at quiescent synapses","volume":"26","author":"Custer","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.seizure.2016.06.001_bib0420","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1242\/jcs.02658","article-title":"SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment","volume":"118","author":"Iezzi","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.seizure.2016.06.001_bib0425","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.neuron.2010.05.010","article-title":"SV2 acts via presynaptic calcium to regulate neurotransmitter release","volume":"66","author":"Wan","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.seizure.2016.06.001_bib0430","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum Reprod Update"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131116300541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131116300541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:47:41Z","timestamp":1761011261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131116300541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":43,"alternative-id":["S1059131116300541"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2016.06.001","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of levetiracetam monotherapy on sperm parameters and sex hormones: Data from newly diagnosed patients with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2016.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 British Epilepsy Association. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}