{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:36:30Z","timestamp":1790804190187,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.seizure.2017.04.007","type":"journal-article","created":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T11:25:26Z","timestamp":1492169126000},"page":"79-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Psychiatric comorbidities in new onset epilepsy: Should they be always investigated?"],"prefix":"10.1016","volume":"49","author":[{"given":"Andres M.","family":"Kanner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2017.04.007_bib0005","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric Comorbidity in Epilepsy: A Population-Based Analysis","volume":"48","author":"Tellez-Zenteno","year":"2007","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.seizure.2017.04.007_bib0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"Epilepsy: a practical clinical definition","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.04.007_bib0015","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/1531-8249(200002)47:2<246::AID-ANA17>3.0.CO;2-E","article-title":"Major depression is a risk factor for seizures in older adults","volume":"47","author":"Hesdorffer","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2017.04.007_bib0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.20685","article-title":"Depression and attempted suicide as risk factors for incident unprovoked seizures and epilepsy","volume":"59","author":"Hesdorffer","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2017.04.007_bib0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.23601","article-title":"Epilepsy, suicidality, and psychiatric disorders: a bidirectional association","volume":"72","author":"Hesdorffer","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2017.04.007_bib0030","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/j.1528-1167.2011.03268.x","article-title":"Bidirectional relation between schizophrenia and epilepsy: a population-based retrospective cohort study","volume":"52","author":"Chang","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.04.007_bib0035","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1212\/WNL.0b013e318245f461","article-title":"Hospitalization for psychiatric disorders before and after onset of unprovoked seizures\/epilepsy","volume":"78","author":"Adelow","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2017.04.007_bib0040","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/archpsyc.61.7.731","article-title":"ADHD as a risk factor for incident unprovoked seizures and epilepsy in children","volume":"61","author":"Hesdorffer","year":"2004","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1016\/j.seizure.2017.04.007_bib0045","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s13311-014-0271-4","article-title":"Biomarkers of epileptogenesis: psychiatric comorbidities (?)","volume":"11","author":"Kanner","year":"2014","journal-title":"Neurotherapeutics"},{"issue":"12","key":"10.1016\/j.seizure.2017.04.007_bib0050","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1474-4422(12)70201-6","article-title":"Can neurobiological pathogenic mechanisms of depression facilitate the development of seizure disorders?","volume":"11","author":"Kanner","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.seizure.2017.04.007_bib0055","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.eplepsyres.2007.06.003","article-title":"Predictors of pharmacoresistant epilepsy","volume":"75","author":"Hitiris","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2017.04.007_bib0060","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1212\/WNL.0b013e3181f25b16","article-title":"Neuropsychiatric symptomatology predicts seizure recurrence in newly treated patients","volume":"75","author":"Petrovski","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2017.04.007_bib0065","first-page":"909","article-title":"Phenobarbital treatment and major depressive disorder in children with epilepsy","volume":"80","author":"Brent","year":"1987","journal-title":"Pediatrics"},{"key":"10.1016\/j.seizure.2017.04.007_bib0070","first-page":"704","article-title":"Psychiatric adverse events during levetiracetam therapy","volume":"61","author":"Mula","year":"2003","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.seizure.2017.04.007_bib0075","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1528-1167.2008.01799.x","article-title":"The role of titration schedule of topiramate for the development of depression in patients with epilepsy","volume":"50","author":"Mula","year":"2009","journal-title":"Epilepsia"},{"issue":"October (5)","key":"10.1016\/j.seizure.2017.04.007_bib0080","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1525-5050(03)00182-3","article-title":"Stress and epilepsy: a patient perception survey","volume":"4","author":"Haut","year":"2003","journal-title":"Epilepsy Behav"},{"issue":"20","key":"10.1016\/j.seizure.2017.04.007_bib0085","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1212\/01.wnl.0000278112.48285.84","article-title":"Seizure occurrence: precipitants and prediction","volume":"69","author":"Haut","year":"2007","journal-title":"Neurology"},{"issue":"Suppl. (5)","key":"10.1016\/j.seizure.2017.04.007_bib0090","first-page":"S9","article-title":"Optimizing Health Outcomes in Active Epilepsy","volume":"58","author":"Gilliam","year":"2002","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.seizure.2017.04.007_bib0095","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.0013-9580.2004.47003.x","article-title":"The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy","volume":"45","author":"Johnson","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.04.007_bib0100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.yebeh.2003.07.009","article-title":"The influence of comorbid depression on quality of life for people with epilepsy","volume":"4","author":"Cramer","year":"2003","journal-title":"Epilepsy Behav"},{"issue":"8","key":"10.1016\/j.seizure.2017.04.007_bib0105","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1474-4422(07)70175-8","article-title":"Epilepsy and risk of suicide: a population-based case-control study","volume":"6","author":"Christensen","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.seizure.2017.04.007_bib0110","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/S0140-6736(13)60899-5","article-title":"Lichtenstein PPremature mortality in epilepsy and the role of psychiatric comorbidity: a total population study","volume":"382","author":"Fazel","year":"2013","journal-title":"Lancet"},{"issue":"July","key":"10.1016\/j.seizure.2017.04.007_bib0115","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yebeh.2014.05.011","article-title":"The relationship of depression to antiepileptic drug adherence and quality of life in epilepsy","volume":"36","author":"Ettinger","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"6","key":"10.1016\/j.seizure.2017.04.007_bib0120","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1528-1167.2012.03488.x","article-title":"Depressive and anxiety disorders in epilepsy: do they differ in their potential to worsen common antiepileptic drug-related adverse events?","volume":"53","author":"Kanner","year":"2012","journal-title":"Epilepsia"},{"issue":"February (2)","key":"10.1016\/j.seizure.2017.04.007_bib0125","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2015.243","article-title":"Management of psychiatric and neurological comorbidities in epilepsy","volume":"12","author":"Kanner","year":"2016","journal-title":"Nat Rev Neurol"},{"issue":"Suppl. (7)","key":"10.1016\/j.seizure.2017.04.007_bib0130","first-page":"80","article-title":"Initial development, reliability, and validity of a patient-based adverse event scale","volume":"35","author":"Baker","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.04.007_bib0135","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1212\/WNL.0b013e318207b073","article-title":"Adverse antiepileptic drug effects in new-onset seizures: a case-control study","author":"Perucca","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2017.04.007_bib0140","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1212\/01.wnl.0000343850.85763.9c","article-title":"A lifetime psychiatric history predicts a worse seizure outcome following temporal lobectomy","volume":"72","author":"Kanner","year":"2009","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.seizure.2017.04.007_bib0145","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/j.1528-1167.2012.03604.x","article-title":"Predictors of psychiatric and seizure outcome following temporal lobe epilepsy surgery","volume":"53","author":"Cleary","year":"2012","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.seizure.2017.04.007_bib0150","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.seizure.2012.07.002","article-title":"Major depressive disorder as a predictor of a worse seizure outcome one year after surgery in patients with temporal lobe epilepsy and mesial temporal sclerosis","author":"de Ara\u00fajo Filho","year":"2012","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2017.04.007_bib0155","series-title":"The Neuropsychiatry of Epilepsy","first-page":"266","article-title":"Psychiatric effects of surgery for temporal lobe epilepsy","author":"Koch-Stoecker","year":"2002"},{"key":"10.1016\/j.seizure.2017.04.007_bib0160","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1469-8749.1979.tb01677.x","article-title":"Long-term outcome in children with temporal lobe seizures: III: Psychiatric aspects in childhood and adult life","volume":"21","author":"Lindsay","year":"1979","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.seizure.2017.04.007_bib0165","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.yebeh.2004.08.003","article-title":"The interictal dysphoric disorder: recognition, pathogenesis, and treatment of the major psychiatric disorder of epilepsy","volume":"5","author":"Blumer","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.04.007_bib0170","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1528-1167.2010.02582.x","article-title":"Anxiety Disorders, Sub-Syndromic Depressive Episodes and Major Depressive Episodes: Do they Differ on their Impact on the Quality of Life of Patients with Epilepsy?","volume":"51","author":"Kanner","year":"2010","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.seizure.2017.04.007_bib0175","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1474-4422(06)70415-X","article-title":"Rapid detection of major depression in epilepsy: a multicenter study","volume":"5","author":"Gilliam","year":"2006","journal-title":"Lancet Neurol"},{"issue":"5","key":"10.1016\/j.seizure.2017.04.007_bib0180","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1528-1167.2005.49704.x","article-title":"Screening for major depression in epilepsy with common self-report depression inventories","volume":"46","author":"Jones","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.04.007_bib0185","doi-asserted-by":"crossref","first-page":"317","DOI":"10.7326\/0003-4819-146-5-200703060-00004","article-title":"Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection","volume":"146","author":"Kroenke","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.seizure.2017.04.007_bib0190","series-title":"The Conners\u2019 Ratings Scales","author":"Conners","year":"1985"},{"issue":"20","key":"10.1016\/j.seizure.2017.04.007_bib0195","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.seizure.2017.04.007_bib0200","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/archpsyc.57.7.675","article-title":"Brief screening for family psychiatric history: the family history screen","volume":"57","author":"Weissman","year":"2000","journal-title":"Arch Gen Psychiatry"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131117302674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131117302674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:48:14Z","timestamp":1761011294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131117302674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":40,"alternative-id":["S1059131117302674"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2017.04.007","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psychiatric comorbidities in new onset epilepsy: Should they be always investigated?","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2017.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd on behalf of British Epilepsy Association.","name":"copyright","label":"Copyright"}]}}