{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:28:02Z","timestamp":1761514082656,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"UCB Pharma Nederland BV"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.seizure.2017.09.017","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T02:16:47Z","timestamp":1507169807000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions"],"prefix":"10.1016","volume":"52","author":[{"given":"J.","family":"Brenner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.M.","family":"Majoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Carpay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2017.09.017_bib0005","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1474-4422(11)70047-3","article-title":"The pharmacological treatment of epilepsy in adults","volume":"10","author":"Perucca","year":"2011","journal-title":"Lancet Neurol"},{"issue":"Suppl. 6","key":"10.1016\/j.seizure.2017.09.017_bib0010","first-page":"45","article-title":"The role of the old and the new antiepileptic drugs in special populations: mental and multiple handicaps","volume":"37","author":"Mattson","year":"1996","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.seizure.2017.09.017_bib0015","first-page":"1","article-title":"Epilepsy and mental retardation: an overview","volume":"98","author":"Coulter","year":"1993","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.seizure.2017.09.017_bib0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/0883073897012001091","article-title":"Meeting the challenge of epilepsy in persons with multiple handicaps","volume":"12","author":"Sunder","year":"1997","journal-title":"J Child Neurol"},{"issue":"2","key":"10.1016\/j.seizure.2017.09.017_bib0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.seizure.2008.07.007","article-title":"Retention of new AEDs in institutionalized intellectually disabled patients with epilepsy","volume":"18","author":"Carpay","year":"2009","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2017.09.017_bib0030","series-title":"NICE guideline (CG137)","article-title":"Epilepsies: diagnosis and management","author":"National Institute for Health and Clinical Excellence","year":"2012"},{"key":"10.1016\/j.seizure.2017.09.017_bib0035","first-page":"1","article-title":"Pharmacological interventions for epilepsy in people with intellectual disabilities","volume":"9","author":"Jackson","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.seizure.2017.09.017_bib0040","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.yebeh.2006.12.005","article-title":"Long-term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability","volume":"10","author":"Simister","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.09.017_bib0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yebeh.2016.10.013","article-title":"Evaluation of perampanel in patients with intellectual disability and epilepsy","volume":"66","author":"Snoeijen-Schouwenaars","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.09.017_bib0050","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.seizure.2008.11.006","article-title":"The impact of side effects on long-term retention in three new antiepileptic drugs","volume":"18","author":"Bootsma","year":"2009","journal-title":"Seizure"},{"issue":"3","key":"10.1016\/j.seizure.2017.09.017_bib0055","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1528-1167.2008.01951.x","article-title":"SP755 Study Group. Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial","volume":"50","author":"Hal\u00e1sz","year":"2009","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.seizure.2017.09.017_bib0060","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1528-1167.2007.01188.x","article-title":"Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures","volume":"48","author":"Ben-Menachem","year":"2007","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.seizure.2017.09.017_bib0065","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1528-1167.2009.02496.x","article-title":"SP754 Study Group. Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial","volume":"51","author":"Chung","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.09.017_bib0070","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.eplepsyres.2013.05.002","article-title":"Long-term retention of lacosamide in a large cohort of people with medically refractory epilepsy: a single centre evaluation","volume":"106","author":"Novy","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2017.09.017_bib0075","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.seizure.2012.05.005","article-title":"Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: a multicentre study in epilepsy clinics in the United Kingdom (UK)","volume":"21","author":"Flores","year":"2012","journal-title":"Seizure"},{"issue":"133","key":"10.1016\/j.seizure.2017.09.017_bib0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/ane.12451","article-title":"SP774 Study Investigators. Long-term adjunctive lacosamide treatment in patients with partial-onset seizures","volume":"2","author":"Rosenow","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.seizure.2017.09.017_bib0085","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.yebeh.2014.09.074","article-title":"SP615 Study Investigators. Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8 years","volume":"41","author":"Rosenfeld","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.09.017_bib0090","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.yebeh.2016.10.029","article-title":"Long-term lacosamide retention \u2013 real world experience at a tertiary epilepsy centre in Ireland","volume":"68","author":"McGinty","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.09.017_bib0095","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yebeh.2017.04.017","article-title":"Lacosamide and concomitant use of antiepileptic and other medications in a US population","volume":"72","author":"Kalilani","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.09.017_bib0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.seizure.2015.10.009","article-title":"Efficacy and tolerability of add-on Lacosamide treatment in adults with Lennox-Gastaut syndrome: an observational study","volume":"33","author":"Andrade-Machado","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2017.09.017_bib0105","doi-asserted-by":"crossref","DOI":"10.1111\/epi.13869","article-title":"Lacosamide in the treatment of patients with epilepsy and intellectual disabilities: a long-term study of 136 patients","author":"B\u00f6ttcher","year":"2017","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.seizure.2017.09.017_bib0110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.otohns.2010.05.007","article-title":"A practical guide to understanding Kaplan-Meier curves","volume":"143","author":"Rich","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.seizure.2017.09.017_bib0115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yebeh.2016.02.041","article-title":"A long-term noninterventional safety study of adjunctive lacosamide therapy in patients with epilepsy and uncontrolled partial-onset seizures","volume":"58","author":"Steinhoff","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.09.017_bib0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yebeh.2017.05.001","article-title":"Effects of adjunctive lacosamide on mood and quality of life in patients with epilepsy","volume":"73","author":"Nakhutina","year":"2017","journal-title":"Epilepsy Behav"},{"year":"2001","series-title":"Current challenges in pharmacovigilance: pragmatic approaches","author":"CIOMS working group V","key":"10.1016\/j.seizure.2017.09.017_bib0125"},{"key":"10.1016\/j.seizure.2017.09.017_bib0130","unstructured":"Netherlands Pharmacovigilance Centre (Lareb). An overview of reports on lacosamide. https:\/\/databankws.lareb.nl\/Downloads\/kwb_2011_2_lacos.pdf (2011)."},{"key":"10.1016\/j.seizure.2017.09.017_bib0135","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jpain.2009.01.322","article-title":"Lacosamide in painful diabetic neuropathy: an 18-week double- blind placebo-controlled trial","volume":"10","author":"Shaibani","year":"2009","journal-title":"J Pain"},{"issue":"10","key":"10.1016\/j.seizure.2017.09.017_bib0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1528-1167.2011.03212.x","article-title":"Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy","volume":"52","author":"Nizam","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.09.017_bib0145","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yebeh.2010.04.043","article-title":"Atrial flutter\/atrial fibrillation associated with lacosamide for partial seizures","volume":"18","author":"DeGiorgio","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2017.09.017_bib0150","unstructured":"European Medicines Agency (EMA). Vimpat: EPAR summary for the public. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Summary_for_the_public\/human\/000863\/WC500050339.pdf (2008) (last updated 24-01-2017)."},{"issue":"Suppl. 11","key":"10.1016\/j.seizure.2017.09.017_bib0155","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1528-1167.2005.00411.x","article-title":"Sudden Unexpected Death in Epilepsy: a review of incidence and risk factors","volume":"46","author":"Tomson","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2017.09.017_bib0160","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1056\/NEJMoa0911610","article-title":"Long-term mortality in childhood-onset epilepsy","volume":"363","author":"Sillanpaa","year":"2010","journal-title":"New Engl J Med"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131117304740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131117304740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:50:04Z","timestamp":1761011404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131117304740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":32,"alternative-id":["S1059131117304740"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2017.09.017","relation":{},"ISSN":["1059-1311"],"issn-type":[{"type":"print","value":"1059-1311"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The retention of lacosamide in patients with epilepsy and intellectual disability in three specialised institutions","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2017.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 British Epilepsy Association. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}