{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:02:17Z","timestamp":1778047337153,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.seizure.2019.04.017","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:19:02Z","timestamp":1556191142000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Impact of antiepileptic drugs for seizure prophylaxis on short and long-term functional outcomes in patients with acute intracerebral hemorrhage: A meta-analysis and systematic review"],"prefix":"10.1016","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-9498","authenticated-orcid":false,"given":"Brian","family":"Spoelhof","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Sanchez-Bautista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-8486","authenticated-orcid":false,"given":"Andres","family":"Zorrilla-Vaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salia","family":"Farrokh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Mirski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brin","family":"Freund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-2283","authenticated-orcid":false,"given":"Lucia","family":"Rivera-Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2019.04.017_bib0005","article-title":"Heart Disease and Stroke Statistics--2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"119","author":"Lloyd-Jones","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.seizure.2019.04.017_bib0010","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1001\/archneur.57.11.1617","article-title":"Seizures after stroke: a prospective multicenter study","volume":"57","author":"Bladin","year":"2000","journal-title":"Arch Neurol"},{"key":"10.1016\/j.seizure.2019.04.017_bib0015","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1212\/01.WNL.0000063316.47591.B4","article-title":"Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome","volume":"60","author":"Vespa","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.04.017_bib0020","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1212\/WNL.32.10.1146","article-title":"Lobar intracerebral hematomas: clinical and CT analysis of 22 cases","volume":"32","author":"Kase","year":"1982","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.04.017_bib0025","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1212\/WNL.38.9.1363","article-title":"Early seizures following intracerebral hemorrhage: implications for therapy","volume":"38","author":"Berger","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.04.017_bib0030","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1528-1167.2007.01513.x","article-title":"Incidence of seizures in the acute phase of stroke: a population-based study","volume":"49","author":"Szaflarski","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.04.017_bib0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jcrc.2008.10.015","article-title":"Predictors of seizure onset after intracerebral hemorrhage and the role of long-term antiepileptic therapy","volume":"24","author":"Garrett","year":"2009","journal-title":"J Crit Care"},{"key":"10.1016\/j.seizure.2019.04.017_bib0040","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1212\/01.wnl.0000281664.02615.6c","article-title":"Electrographic seizures and periodic discharges after intracerebral hemorrhage","volume":"69","author":"Claassen","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.04.017_bib0045","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1161\/STROKEAHA.109.559948","article-title":"Anticonvulsant use and outcomes after intracerebral hemorrhage","volume":"40","author":"Naidech","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.seizure.2019.04.017_bib0050","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1046\/j.1528-1157.2002.00302.x","article-title":"Seizures after spontaneous supratentorial intracerebral hemorrhage","volume":"43","author":"Passero","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.04.017_bib0055","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.eplepsyres.2014.02.020","article-title":"Immediate, early and late seizures after primary intracerebral hemorrhage","volume":"108","author":"Qian","year":"2014","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2019.04.017_bib0060","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.clineuro.2007.04.001","article-title":"Seizures and epilepsy in patients with a spontaneous intracerebral haematoma","volume":"109","author":"De Reuck","year":"2007","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.seizure.2019.04.017_bib0065","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.clineuro.2011.07.008","article-title":"The prophylactic use of an antiepileptic drug in intracerebral hemorrhage","volume":"113","author":"Reddig","year":"2011","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.seizure.2019.04.017_bib0070","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.05.026","article-title":"Prophylactic Use of Antiepileptic Drugs in Patients with Spontaneous Intracerebral Hemorrhage","volume":"25","author":"Zandieh","year":"2016","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.seizure.2019.04.017_bib0075","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.seizure.2013.03.011","article-title":"Seizures and antiepileptic drugs in patients with spontaneous intracerebral hemorrhages","volume":"22","author":"Srinivasan","year":"2013","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2019.04.017_bib0080","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1179\/1743132813Y.0000000197","article-title":"Survey of prophylactic antiseizure drug use for non-traumatic intracerebral hemorrhage","volume":"35","author":"Jensen","year":"2013","journal-title":"Neurol Res"},{"key":"10.1016\/j.seizure.2019.04.017_bib0085","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/STR.0000000000000069","article-title":"Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals from the American Heart Association\/American Stroke Association","volume":"46","author":"Hemphill","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.seizure.2019.04.017_bib0090","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.seizure.2019.04.017_bib0095","series-title":"The cochrane collaboration","article-title":"Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]","author":"Higgins","year":"2011"},{"key":"10.1016\/j.seizure.2019.04.017_bib0100","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12028-012-9776-z","article-title":"Confounding by indication in retrospective studies of intracerebral hemorrhage: antiepileptic treatment and mortality","volume":"17","author":"Battey","year":"2012","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.seizure.2019.04.017_bib0105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.eplepsyres.2011.04.002","article-title":"Are post intracerebral hemorrhage seizures prevented by anti-epileptic treatment?","volume":"95","author":"Gilad","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2019.04.017_bib0110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s12028-009-9207-y","article-title":"Prophylactic antiepileptic drug use is associated with poor outcome following ICH","volume":"11","author":"Mess\u00e9","year":"2009","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.seizure.2019.04.017_bib0115","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1161\/STROKEAHA.115.010875","article-title":"Prophylactic antiepileptic drug use and outcome in the Ethnic\/Racial variations of intracerebral hemorrhage study","volume":"46","author":"Sheth","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.seizure.2019.04.017_bib0120","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1093\/brain\/aww199","article-title":"Delayed seizures after intracerebral haemorrhage","volume":"139","author":"Biffi","year":"2016","journal-title":"Brain."},{"key":"10.1016\/j.seizure.2019.04.017_bib0125","first-page":"S282","article-title":"Levetiracetam versus phenytoin for seizure prophylaxis in patients admitted with subarachnoid or inracerebral hemorrhage: a retrospective study","volume":"17","author":"Hashim","year":"2012","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.seizure.2019.04.017_bib0130","first-page":"S1","article-title":"Effect of prophylactic antiepileptic drugs on seizures in patients with nontraumatic intracranial hemorrhage","volume":"12","author":"Rapaport","year":"2012","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.seizure.2019.04.017_bib0135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12028-010-9341-6","article-title":"Levetiracetam is associated with improved cognitive outcome for patients with intracranial hemorrhage","volume":"15","author":"Taylor","year":"2011","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.seizure.2019.04.017_bib0140","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s00415-017-8573-1","article-title":"Mortality after primary intracerebral hemorrhage in relation to post-stroke seizures","volume":"264","author":"Claessens","year":"2017","journal-title":"J Neurol"},{"key":"10.1016\/j.seizure.2019.04.017_bib0145","first-page":"1","article-title":"Antiepileptic drugs for patients with intracerebral hemorrhage \u2014 a meta analysis","author":"Yao","year":"2016","journal-title":"Turk Neurosurg"},{"key":"10.1016\/j.seizure.2019.04.017_bib0150","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1212\/WNL.0b013e3182364878","article-title":"Incidence and predictors of acute symptomatic seizures after stroke","volume":"77","author":"Beghi","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.04.017_bib0155","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3171\/2009.2.JNS081622","article-title":"Predictors and outcome of seizures after spontaneous intracerebral hemorrhage. Clinical article","volume":"111","author":"Yang","year":"2009","journal-title":"J Neurosurg"},{"key":"10.1016\/j.seizure.2019.04.017_bib0160","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/STROKEAHA.111.000232","article-title":"Incidence and predictors of late seizures in intracerebral hemorrhages","volume":"44","author":"Rossi","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.seizure.2019.04.017_bib0165","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1212\/WNL.0b013e31823648a6","article-title":"Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome","volume":"77","author":"De Herdt","year":"2011","journal-title":"Neurolog"},{"key":"10.1016\/j.seizure.2019.04.017_bib0170","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.021","article-title":"Association between seizures and outcomes among intracerebral hemorrhage patients: the China National Stroke Registry","volume":"24","author":"Li","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.seizure.2019.04.017_bib0175","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/phar.1374","article-title":"Seizure prophylaxis in neurocritical care: a review of evidence-based support","volume":"34","author":"Rowe a","year":"2014","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.seizure.2019.04.017_bib0180","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1161\/STROKEAHA.116.012410","article-title":"Review of the utility of prophylactic anticonvulsant use in critically ill patients with intracerebral hemorrhage","volume":"47","author":"Gilmore","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.seizure.2019.04.017_bib0185","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jocn.2014.03.009","article-title":"Incidence of delayed seizures, delayed cerebral ischemia and poor outcome with the use of levetiracetam versus phenytoin after aneurysmal subarachnoid hemorrhage","volume":"21","author":"Karamchandani","year":"2014","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.seizure.2019.04.017_bib0190","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/STR.0000000000000069","article-title":"Guidelines for the management of spontaneous intracerebral hemorrhage","volume":"46","author":"Hemphill","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.seizure.2019.04.017_bib0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1212\/WNL.0000000000003461","article-title":"Evolving use of seizure medications after intracerebral hemorrhage: a multicenter study","volume":"88","author":"Naidech","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.04.017_bib0200","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/WNL.0000000000003467","article-title":"AEDs after ICH: preventing the prophylaxis","volume":"88","author":"Koch","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.04.017_bib0205","first-page":"1","article-title":"Drug interactions in Neurocritical Care","author":"Spoelhof","year":"2017","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.seizure.2019.04.017_bib0210","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.seizure.2015.07.004","article-title":"The adverse event profile of levetiracetam: a meta-analysis on children and adults","volume":"31","author":"Verrotti","year":"2015","journal-title":"Seizure"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131118304345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131118304345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:53:56Z","timestamp":1761011636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131118304345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":42,"alternative-id":["S1059131118304345"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2019.04.017","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of antiepileptic drugs for seizure prophylaxis on short and long-term functional outcomes in patients with acute intracerebral hemorrhage: A meta-analysis and systematic review","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2019.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 British Epilepsy Association. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}