{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:24:48Z","timestamp":1790846688048,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.seizure.2019.11.003","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T19:22:58Z","timestamp":1573068178000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Influence of new versus traditional antiepileptic drugs on course and outcome of status epilepticus"],"prefix":"10.1016","volume":"74","author":[{"given":"Caroline","family":"Reindl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian I.","family":"Spr\u00fcgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen A.","family":"Sembill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara M.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T.","family":"Gerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji B.","family":"Kuramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajo M.","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen B.","family":"Huttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Mad\u017ear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2019.11.003_bib0005","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1046\/j.1528-1157.2001.01101.x","article-title":"Incidence of status epilepticus in adults in Germany: a prospective, population-based study","volume":"42","author":"Knake","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0010","article-title":"Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes","author":"Leitinger","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0015","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/jnnp.2005.080887","article-title":"Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation","volume":"77","author":"Rossetti","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.seizure.2019.11.003_bib0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/epi.12903","article-title":"Recurrence of status epilepticus: prognostic role and outcome predictors","volume":"56","author":"Tsetsou","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0025","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/ene.13073","article-title":"A new clinical score for the prognosis of status epilepticus in adults","volume":"23","author":"Gonzalez-Cuevas","year":"2016","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.seizure.2019.11.003_bib0030","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s00415-008-0989-1","article-title":"Status epilepticus severity score (STESS): a tool to orient early treatment strategy","volume":"255","author":"Rossetti","year":"2008","journal-title":"J Neurol"},{"key":"10.1016\/j.seizure.2019.11.003_bib0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12028-014-0080-y","article-title":"Epidemiology-based mortality score in status epilepticus (EMSE)","volume":"22","author":"Leitinger","year":"2015","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.seizure.2019.11.003_bib0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1528-1157.1999.tb02069.x","article-title":"The EEG and prognosis in status epilepticus","volume":"40","author":"Nei","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/ane.12605","article-title":"Refractory and super-refractory status epilepticus in adults: a 9- year cohort study","volume":"135","author":"Delaj","year":"2017","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.seizure.2019.11.003_bib0050","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/epi.13837","article-title":"Costs, length of stay, and mortality of super-refractory status epilepticus: A population-based study from Germany","volume":"58","author":"Strzelczyk","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrd2997","article-title":"Key factors in the discovery and development of new antiepileptic drugs","volume":"9","author":"Bialer","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.seizure.2019.11.003_bib0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s40263-017-0424-1","article-title":"Newer antiepileptic drugs in Status epilepticus: prescription trends and outcomes in comparison with traditional agents","volume":"31","author":"Beuchat","year":"2017","journal-title":"CNS Drugs"},{"issue":"Suppl. 8","key":"10.1016\/j.seizure.2019.11.003_bib0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1528-1167.2011.03237.x","article-title":"Established status epilepticus treatment trial (ESETT)","volume":"52","author":"Cock","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0070","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1111\/epi.14434","article-title":"Use of newer antiepileptic drugs and prognosis in adults with status epilepticus: comparison between 2009 and 2017","volume":"59","author":"Fatuzzo","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2008.09.005","article-title":"Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (Eilat IX)","volume":"83","author":"Bialer","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2019.11.003_bib0080","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.addr.2011.11.006","article-title":"Chemical properties of antiepileptic drugs (AEDs)","volume":"64","author":"Bialer","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.seizure.2019.11.003_bib0085","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1528-1157.1999.tb02000.x","article-title":"It\u2019s time to revise the definition of status epilepticus","volume":"40","author":"Lowenstein","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0090","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus--report of the ILAE task force on classification of Status epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/ene.12531","article-title":"Early predictors of refractory status epilepticus: an international two-center study","volume":"22","author":"Sutter","year":"2015","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.seizure.2019.11.003_bib0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12028-012-9695-z","article-title":"Guidelines for the evaluation and management of status epilepticus","volume":"17","author":"Brophy","year":"2012","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.seizure.2019.11.003_bib0105","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1468-1331.2009.02917.x","article-title":"EFNS guideline on the management of status epilepticus in adults","volume":"17","author":"Meierkord","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.seizure.2019.11.003_bib0110","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0196-0644(05)80120-9","article-title":"Refractory status epilepticus in adults","volume":"22","author":"Jagoda","year":"1993","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.seizure.2019.11.003_bib0115","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/01.wnl.0000223352.71621.97","article-title":"A clinical score for prognosis of status epilepticus in adults","volume":"66","author":"Rossetti","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.11.003_bib0120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/003693305700200504","article-title":"Cerebral vascular accidents in patients over the age of 60. II. Prognosis","volume":"2","author":"Rankin","year":"1957","journal-title":"Scott Med J"},{"key":"10.1016\/j.seizure.2019.11.003_bib0125","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archneur.59.2.205","article-title":"Refractory status epilepticus: frequency, risk factors, and impact on outcome","volume":"59","author":"Mayer","year":"2002","journal-title":"Arch Neurol"},{"key":"10.1016\/j.seizure.2019.11.003_bib0130","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000004147","article-title":"Emergency response to out-of-hospital status epilepticus: A 10-year observational cohort study","author":"Semmlack","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2019.11.003_bib0135","doi-asserted-by":"crossref","DOI":"10.1002\/ana.25416","article-title":"Factors predicting cessation of status epilepticus in clinical practice - data from a prospective observational registry (SENSE)","author":"Kellinghaus","year":"2019","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2019.11.003_bib0140","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/epi.13056","article-title":"Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparison","volume":"56","author":"Alvarez","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0145","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1528-1167.2011.03056.x","article-title":"Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam","volume":"52","author":"Alvarez","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2019.11.003_bib0150","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","article-title":"Treatment outcomes in patients with newly diagnosed epilepsy treated with established and New antiepileptic drugs: A 30-year longitudinal cohort study","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.seizure.2019.11.003_bib0155","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(07)60460-7","article-title":"The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.seizure.2019.11.003_bib0160","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1528-1167.2012.03416.x","article-title":"Focal epilepsies in adult patients attending two epilepsy centers: classification of drug-resistance, assessment of risk factors, and usefulness of \u201cnew\u201d antiepileptic drugs","volume":"53","author":"Gilioli","year":"2012","journal-title":"Epilepsia"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131119302754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131119302754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:53:25Z","timestamp":1761011605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131119302754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":32,"alternative-id":["S1059131119302754"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2019.11.003","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of new versus traditional antiepileptic drugs on course and outcome of status epilepticus","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2019.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 British Epilepsy Association. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}