{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:23:59Z","timestamp":1791080639099,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.seizure.2020.10.021","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T03:55:03Z","timestamp":1604030103000},"page":"154-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study"],"prefix":"10.1016","volume":"83","author":[{"given":"Claudia","family":"Basti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Maranella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cimini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Catalucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Ciccarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Del Torto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Di Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Di Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Mareri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Pannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Di Fabio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.seizure.2020.10.021_bib0005","first-page":"329","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"EarlyHum Dev"},{"key":"10.1016\/j.seizure.2020.10.021_bib0010","doi-asserted-by":"crossref","first-page":"e459","DOI":"10.1542\/peds.2008-2190","article-title":"Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years","volume":"124","author":"Murray","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.seizure.2020.10.021_bib0015","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/0883073810380915","article-title":"Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental out come secondary analyses of data from the neonatal research network hypothermia trial","volume":"26","author":"Kwon","year":"2011","journal-title":"J Child Neurol"},{"issue":"1","key":"10.1016\/j.seizure.2020.10.021_bib0020","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.seizure.2020.10.021_bib0025","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1542\/peds.2014-0899","article-title":"Hypothermia and neonatal encephalopathy","volume":"133","author":"Committee on Fetus and Newborn","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.seizure.2020.10.021_bib0030","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1542\/peds.2007-1839","article-title":"Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants","volume":"121","author":"Shah","year":"2008","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.seizure.2020.10.021_bib0035","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/jp.2017.14","article-title":"Predictive value of amplitude-integrated EEG [aEEG] after rescue hypothermic neuroprotection for hypoxic ischemic encephalopathy: a meta-analysis","volume":"37","author":"Chandrasekaran","year":"2017","journal-title":"J Perinatol"},{"key":"10.1016\/j.seizure.2020.10.021_bib0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.seizure.2020.10.021_bib0045","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jpeds.2011.07.015","article-title":"Seizures and magnetic resonance imaging-detected brain injury in newborns cooled for hypoxic-ischemic encephalopathy","volume":"159","author":"Glass","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.seizure.2020.10.021_bib0050","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1542\/peds.2009-0136","article-title":"Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial","volume":"125","author":"Van Rooij","year":"2010","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.seizure.2020.10.021_bib0055","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1542\/peds.111.2.351","article-title":"Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy","volume":"111","author":"Shalak","year":"2003","journal-title":"Pediatrics"},{"issue":"14","key":"10.1016\/j.seizure.2020.10.021_bib0060","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.seizure.2020.10.021_bib0065","series-title":"Italian guidelines for therapeutic hypothermia","author":"Ancora","year":"2012"},{"key":"10.1016\/j.seizure.2020.10.021_bib0070","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1542\/peds.103.6.1263","article-title":"Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography","volume":"103","author":"al Naqeeb","year":"1999","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.seizure.2020.10.021_bib0075","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1136\/fn.81.1.F19","article-title":"Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy","volume":"81","author":"Hellstrom-Westas","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.seizure.2020.10.021_bib0080","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/dmcn.13215","article-title":"Seizure burden and neurodevelopmental out come in neonates with hypoxic ischemic encephalopathy","volume":"58","author":"Kharoshankaya","year":"2016","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.seizure.2020.10.021_bib0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clp.2013.10.005","article-title":"Mechanisms of hypothermic neuroprotection","volume":"41","author":"Drury","year":"2014","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.seizure.2020.10.021_bib0090","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.410320511","article-title":"Suppression of postischemic epileptiform activity with MK-801 improves neural outcome in fetal sheep","volume":"32","author":"Tan","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2020.10.021_bib0095","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1212\/WNL.58.4.542","article-title":"Seizure-associated brain injury in term newborns with perinatal asphyxia","volume":"58","author":"Miller","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2020.10.021_bib0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ana.21167","article-title":"Neonatal seizures","volume":"62","author":"Silverstein","year":"2007","journal-title":"Ann Neurol"},{"issue":"6","key":"10.1016\/j.seizure.2020.10.021_bib0105","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/epi.13745","article-title":"Early discontinuation of anti-seizure medications in neonates with hypoxic-ischemic encephalopathy","volume":"58","author":"Fitzgerald","year":"2017","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.seizure.2020.10.021_bib0110","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/jp.2013.116","article-title":"Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures","volume":"33","author":"Maitre","year":"2013","journal-title":"J Perinatol"},{"key":"10.1016\/j.seizure.2020.10.021_bib0115","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of Hypothermia on Amplitude-Integrated Electroencephalogram in Infants With Asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.seizure.2020.10.021_bib0120","series-title":"Amplitude integrated electroencephalogram as a prognostic tool in neonates with hypoxic-ischemic encephalopathy: a systematic review","author":"Ochoa","year":"2020"},{"key":"10.1016\/j.seizure.2020.10.021_bib0125","series-title":"Evolution of amplitude-integrated electroencephalogram as a predictor of outcome in term encephalopathic neonates receiving therapeutic hypothermia","author":"Sewell","year":"2020"},{"key":"10.1016\/j.seizure.2020.10.021_bib0130","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41390-018-0040-x","article-title":"Predictive value of early EEG for seizures in neonates with hypoxic\u2013ischemic encephalopathy undergoing therapeutic hypothermia","volume":"84","author":"Cornet","year":"2018","journal-title":"Pediatr Res"},{"key":"10.1016\/j.seizure.2020.10.021_bib0135","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1542\/peds.2008-1000","article-title":"Amplitude integrated electroencephalography in the newborns: a valuable tool","volume":"122","author":"Shah","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.seizure.2020.10.021_bib0140","series-title":"Acute neonatal encephalopathy and seizures recurrence: a combined aEEG\/EEG study","author":"Mastrangelo","year":"2020"},{"key":"10.1016\/j.seizure.2020.10.021_bib0145","doi-asserted-by":"crossref","DOI":"10.1136\/archdischild-2011-301524","article-title":"Brain injury followingtrial of hypothermia for neonatal hypoxic-ischaemicencephalopathy","volume":"97","author":"Shankaran","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.seizure.2020.10.021_bib0150","doi-asserted-by":"crossref","DOI":"10.1542\/peds.102.2.323","article-title":"Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxicischemic encephalopathy","volume":"102","author":"Rutherford","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.seizure.2020.10.021_bib0155","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1212\/WNL.0b013e31821f442d","article-title":"Predicting motor outcome and death in term hypoxicischemic encephalopathy","volume":"76","author":"Martinez-Biarge","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2020.10.021_bib0160","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/dmcn.13195","article-title":"Hypothermia reduces seizure burden and improves neurological outcome in severe hypoxic-ischemic encephalopathy: an observational study","volume":"58","author":"Guidotti","year":"2016","journal-title":"Dev Med Child Neurol"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131120303393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131120303393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:57:09Z","timestamp":1761011829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131120303393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":32,"alternative-id":["S1059131120303393"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2020.10.021","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2020.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 British Epilepsy Association. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}