{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:55:55Z","timestamp":1793051755038,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.seizure.2020.10.024","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T02:24:47Z","timestamp":1607999087000},"page":"243-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Carbamazepine \u2013An oldie but a goodie\u2013A clinician\u2019s perspective"],"prefix":"10.1016","volume":"83","author":[{"given":"Roy G.","family":"Beran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 1","key":"10.1016\/j.seizure.2020.10.024_bib0005","article-title":"\u00c4 quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012","volume":"18","author":"Tolou-Ghamari","year":"2013","journal-title":"J Res Med Sci"},{"issue":"1","key":"10.1016\/j.seizure.2020.10.024_bib0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1526-4610.1969.hed0901054.x","article-title":"A four year double-blind study of Tegretol \u00ae in facial pain","volume":"6","author":"Nicol","year":"1969","journal-title":"Headache"},{"issue":"4","key":"10.1016\/j.seizure.2020.10.024_bib0015","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/00007691-198612000-00021","article-title":"Discovery of phenytoin","volume":"8","author":"Glazko","year":"1986","journal-title":"Ther Drug Monit"},{"issue":"2","key":"10.1016\/j.seizure.2020.10.024_bib0020","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/hlca.19540370211","article-title":"Uber derivatives des iminodibenzyls","volume":"37","author":"Schindler","year":"1954","journal-title":"Helvetica"},{"issue":"1","key":"10.1016\/j.seizure.2020.10.024_bib0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1176\/ajp.143.1.29","article-title":"Antidepressant effects of carbamazepine","volume":"143","author":"Post","year":"1986","journal-title":"Am J Psychiatry"},{"issue":"6","key":"10.1016\/j.seizure.2020.10.024_bib0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1212\/01.wnl.0000252941.50833.4a","article-title":"Comparison of leviteracetam and controlled-release carbamazepine in newly diagnosed epilepsy","volume":"68","author":"Brodie","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2020.10.024_bib0035","article-title":"Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review","volume":"11","author":"Nevitt","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"9566","key":"10.1016\/j.seizure.2020.10.024_bib0040","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(07)60460-7","article-title":"The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.seizure.2020.10.024_bib0045","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1684\/epd.2012.0531","article-title":"Randomised controlled monotherapy trials: which comparators to use","volume":"14","author":"Beghi","year":"2012","journal-title":"Epileptic Disord"},{"issue":"6","key":"10.1016\/j.seizure.2020.10.024_bib0050","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1212\/WNL.53.6.1170","article-title":"Carbamazepine in comparative trials - Pharmacokinetic characteristics too often forgotten","volume":"53","author":"Arroyo","year":"1999","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.seizure.2020.10.024_bib0055","first-page":"411","article-title":"Selective liver enzyme induction by carbamazepine and phenytoin in Chinese epileptics","volume":"50","author":"Tomlinson","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.seizure.2020.10.024_bib0060","doi-asserted-by":"crossref","first-page":"g254","DOI":"10.1136\/bmj.g254","article-title":"Drug treatment of epilepsy in adults","volume":"348","author":"Schmidt","year":"2014","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.seizure.2020.10.024_bib0065","first-page":"493","article-title":"Assessing to cost-effectiveness of new pharmaceuticals in epilepsy in adults: The results of a probabilistic decision model","volume":"25","author":"Hawkins","year":"2005","journal-title":"J Indexing Metrics"},{"issue":"1","key":"10.1016\/j.seizure.2020.10.024_bib0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/0976-500X.124428","article-title":"Anticonvulsant hypersensitivity syndrome associated with carbamazepine administration: case series","volume":"5","author":"Mehta","year":"2014","journal-title":"J Pharmacol Pharmacother"},{"issue":"4","key":"10.1016\/j.seizure.2020.10.024_bib0075","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.seizure.2010.12.011","article-title":"Gastrointestinal adverse effects of antiepileptic drugs in intractable epileptic patients","volume":"20","author":"Jahromi","year":"2011","journal-title":"Seizure"},{"issue":"1\u20133","key":"10.1016\/j.seizure.2020.10.024_bib0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2013.09.013","article-title":"A review of antiepileptic drug-dependant fatigue: pathophysiological mechanisms and incidence","volume":"718","author":"Siniscalchi","year":"2013","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"10.1016\/j.seizure.2020.10.024_bib0085","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1517\/14656566.2016.1168399","article-title":"Carbamazepine-related antiepileptic drugs for the treatment of epilepsy \u2013 a comparative review","volume":"17","author":"Gierbolini","year":"2016","journal-title":"Expert Opin Pharmacother"},{"issue":"Suppl 1","key":"10.1016\/j.seizure.2020.10.024_bib0090","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.0013-9580.2004.451006.x","article-title":"Treatment of photosensitivity","volume":"45","author":"Covanis","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2020.10.024_bib0095","doi-asserted-by":"crossref","first-page":"426","DOI":"10.5694\/j.1326-5377.1984.tb108107.x","article-title":"Leucopenia as an adverse reaction to carbamazepine therapy","volume":"1","author":"Rush","year":"1984","journal-title":"Med J Aust"},{"issue":"9","key":"10.1016\/j.seizure.2020.10.024_bib0100","first-page":"0D12","article-title":"Carbamazepine induced thrombocytopenia","volume":"11","author":"Kumar","year":"2017","journal-title":"J Clin Diagn Res"},{"issue":"12","key":"10.1016\/j.seizure.2020.10.024_bib0105","first-page":"1214","article-title":"A review of carbamazepine hASMatologic reactions and monitoring recommendations","volume":"24","author":"Sobotka","year":"1991","journal-title":"Annals Pharmacother"},{"key":"10.1016\/j.seizure.2020.10.024_bib0110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.seizure.2019.01.014","article-title":"Co-medication and potential drug interactions among patients with epilepsy","volume":"66","author":"Bosak","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2020.10.024_bib0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neulet.2017.01.014","article-title":"Pharmacogenonomics in epilepsy","volume":"667","author":"Balestrini","year":"2018","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.seizure.2020.10.024_bib0120","series-title":"Carbamazepine therapy and HLA genotypes in medical genetics summaries","first-page":"87","author":"Dean","year":"2012"},{"issue":"4","key":"10.1016\/j.seizure.2020.10.024_bib0125","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/epi.12937","article-title":"Cost-effectiveness of screening for HLA-A 31:01 prior to initiation of carbamazepine in epilepsy","volume":"56","author":"Plumpton","year":"2015","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.seizure.2020.10.024_bib0130","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1001\/archneur.61.8.1328-a","article-title":"Evolving antiepileptic drug treatment in juvenile myoclonic epilepsy","volume":"61","author":"Grunewald","year":"2004","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.seizure.2020.10.024_bib0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1528-1157.1998.tb01268.x","article-title":"Antiepileptic drugs as a cause of worsening seizures","volume":"39","author":"Perucca","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2020.10.024_bib0140","first-page":"1","article-title":"New recommendations for antiepileptic drugs therapy: the last piece in the review of epilepsy care","volume":"117","author":"Tomson","year":"2020","journal-title":"Medicinsk Kommenstar (Lakartigningen)"},{"key":"10.1016\/j.seizure.2020.10.024_bib0145","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.yebeh.2013.10.027","article-title":"Rectal carbamazepine as effective long-acting treatment after cluster seizures and status epilepticus","volume":"31","author":"Patel","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"3","key":"10.1016\/j.seizure.2020.10.024_bib0150","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.yebeh.2007.12.013","article-title":"An alternative perspective on the management of status epilepticus","volume":"12","author":"Beran","year":"2008","journal-title":"Epilepsy Behav"},{"issue":"3","key":"10.1016\/j.seizure.2020.10.024_bib0155","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/157015910792246254","article-title":"Antiepileptic drug interactions \u2013 principles and clinical implications","volume":"8","author":"Johannessen","year":"2010","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.seizure.2020.10.024_bib0160","first-page":"185","article-title":"Therapeutic drug monitoring \u2013 antiepileptic drugs","volume":"46","author":"Eadie","year":"1998","journal-title":"J Clin Pharmacol"},{"issue":"9","key":"10.1016\/j.seizure.2020.10.024_bib0165","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1001\/archneur.62.9.1432","article-title":"Effect of antiepileptic drug comedication on lamotrigine clearance","volume":"62","author":"Weintraub","year":"2005","journal-title":"Arch Neurol"},{"issue":"2","key":"10.1016\/j.seizure.2020.10.024_bib0170","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1528-1167.2010.02917.x","article-title":"Carbamazepine co-administration with an oral contraceptive: effects on steroid pharmacokinetics, ovulation and bleeding","volume":"52","author":"Davis","year":"2011","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.seizure.2020.10.024_bib0175","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/jth.13268","article-title":"The effect of carbamazepine on warfarin anticoagulation: a register-based nationwide cohort study involving the Swedish population","volume":"14","author":"Maunheimer","year":"2016","journal-title":"J ThrombHASMost"},{"issue":"8","key":"10.1016\/j.seizure.2020.10.024_bib0180","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/jnnp.41.8.713","article-title":"Water intoxication in epileptic patients receiving carbamazepine","volume":"41","author":"Perucca","year":"1978","journal-title":"J Neurol Neurosurg Psychiatr"},{"issue":"12","key":"10.1016\/j.seizure.2020.10.024_bib0185","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1111\/j.1528-1167.2006.00861.x","article-title":"Electrolytes disturbances and seizures","volume":"47","author":"Castilla-Guerra","year":"2006","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.seizure.2020.10.024_bib0190","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/00007611-197804000-00011","article-title":"Severe electrolyte disturbance associated with metolazone and furosemide","volume":"71","author":"Black","year":"1978","journal-title":"South Med J"},{"issue":"3","key":"10.1016\/j.seizure.2020.10.024_bib0195","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/17425255.2020.1724956","article-title":"Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects","volume":"16","author":"Johannessen Landmark","year":"2020","journal-title":"Expert Opinion Drug Metab Toxicol"},{"key":"10.1016\/j.seizure.2020.10.024_bib0200","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.seizure.2014.02.003","article-title":"Measurement of leviteracetam drug levels to assist with seizure control and monitoring of drug interactions with other antiepileptic medications (ASMs)","volume":"23","author":"Stepanova","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2020.10.024_bib0205","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.seizure.2007.12.007","article-title":"Value of therapeutic drug level monitoring and unbound (free) level","volume":"17","author":"Chan","year":"2008","journal-title":"Seizure"},{"issue":"8","key":"10.1016\/j.seizure.2020.10.024_bib0210","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/archneur.1990.00530080072013","article-title":"Carbamazepine \u2013 10, 11 \u2013 epoxide in epilepsy. A pilot study","volume":"47","author":"Tomson","year":"1990","journal-title":"Arch Neurol"},{"issue":"Suppl 3","key":"10.1016\/j.seizure.2020.10.024_bib0215","first-page":"569","article-title":"Role of carbamazepine epoxide in the assessment of patients with epilepsy","volume":"36","author":"Beran","year":"1995","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.seizure.2020.10.024_bib0220","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1528-1157.1998.tb01372.x","article-title":"Pharmacokinetic evaluation of twice daily extended release carbamazepine (CBZ) and four times daily immediate release CBZ in patients with epilepsy","volume":"39","author":"Garnett","year":"1998","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.seizure.2020.10.024_bib0225","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/epi.13655","article-title":"A systematic review of economic evaluations of treatments for patients with epilepsy","volume":"58","author":"Wijnen","year":"2017","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.seizure.2020.10.024_bib0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1046\/j.0306-5251.2001.01436.x","article-title":"A pharmacoeconomic analysis of the impact of therapeutic drug monitoring in adults with generalised tonic-clonic epilepsy","volume":"52","author":"Rane","year":"2001","journal-title":"Br J Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.seizure.2020.10.024_bib0235","first-page":"18","article-title":"Evaluating the factors affecting the quality of life and total costs in epilepsy patients on monotherapy with carbamazepine and valproate","volume":"50","author":"Balabanov","year":"2008","journal-title":"Folio Med Plovdir"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131120303423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131120303423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:58:25Z","timestamp":1761011905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131120303423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":47,"alternative-id":["S1059131120303423"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2020.10.024","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbamazepine \u2013An oldie but a goodie\u2013A clinician\u2019s perspective","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2020.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd on behalf of British Epilepsy Association.","name":"copyright","label":"Copyright"}]}}