{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:53:24Z","timestamp":1784098404465,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure: European Journal of Epilepsy"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.seizure.2022.10.017","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T12:32:11Z","timestamp":1666182731000},"page":"46-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Intolerance to quinidine in a n-of-1 trial for KCNT1 associated epilepsy of infancy with migrating focal seizures"],"prefix":"10.1016","volume":"103","author":[{"given":"Elaine","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Oates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deb K","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2022.10.017_bib0002","unstructured":"KCNT1-Related Epilepsy. [Internet]. GeneReviews\u00ae [Internet]. 2018. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK525917\/."},{"issue":"3","key":"10.1016\/j.seizure.2022.10.017_bib0003","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.24229","article-title":"Targeted treatment of migrating partial seizures of infancy with quinidine","volume":"76","author":"Bearden","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2022.10.017_bib0004","doi-asserted-by":"crossref","unstructured":"Burbano L.E., Li M., Jancovski N., Jafar-Nejad P., Richards K., Sedo A., et\u00a0al. Antisense oligonucleotide therapy for KCNT1 encephalopathy. bioRxiv. 2020:2020.11.12.379164.","DOI":"10.1101\/2020.11.12.379164"},{"issue":"4","key":"10.1016\/j.seizure.2022.10.017_bib0005","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/hrt.66.4.301","article-title":"Quinine and quinidine","volume":"66","author":"Hollman","year":"1991","journal-title":"Br Heart J"},{"key":"10.1016\/j.seizure.2022.10.017_bib0006","series-title":"Cardiac electrophysiology: from cell to bedside","article-title":"Standard antiarrhythmic drugs","author":"Darbar","year":"2018"},{"issue":"4","key":"10.1016\/j.seizure.2022.10.017_bib0007","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ana.24128","article-title":"KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine","volume":"75","author":"Milligan","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2022.10.017_bib0008","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mcn.2016.01.004","article-title":"Characterization of two de novoKCNT1 mutations in children with malignant migrating partial seizures in infancy","volume":"72","author":"Rizzo","year":"2016","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"10.1016\/j.seizure.2022.10.017_bib0009","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.braindev.2016.08.002","article-title":"Quinidine therapy for West syndrome with KCNTI mutation: a case report","volume":"39","author":"Fukuoka","year":"2017","journal-title":"Brain Dev"},{"issue":"6","key":"10.1016\/j.seizure.2022.10.017_bib0010","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/ana.24520","article-title":"Quinidine in the treatment of KCNT1-positive epilepsies","volume":"78","author":"Mikati","year":"2015","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.seizure.2022.10.017_bib0011","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ana.24598","article-title":"Ineffective quinidine therapy in early onset epileptic encephalopathy with KCNT1 mutation","volume":"79","author":"Chong","year":"2016","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.seizure.2022.10.017_bib0012","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s13311-019-00739-y","article-title":"Treatment responsiveness in KCNT1-related epilepsy","volume":"16","author":"Fitzgerald","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.seizure.2022.10.017_bib0013","doi-asserted-by":"crossref","DOI":"10.1055\/s-0035-1550734","article-title":"Quinidine: a targeted drug treatment for patients with the syndrome of malignant migrating partial seizures in infancy and KCNT1 mutation","volume":"46","author":"Dietel","year":"2015","journal-title":"Neuropediatrics"},{"issue":"12","key":"10.1016\/j.seizure.2022.10.017_bib0014","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S1474-4422(15)00199-4","article-title":"A roadmap for precision medicine in the epilepsies","volume":"14","year":"2015","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.seizure.2022.10.017_bib0015","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1212\/WNL.0000000000004769","article-title":"Precision therapy for epilepsy due to KCNT1 mutations: a randomized trial of oral quinidine","volume":"90","author":"Mullen","year":"2018","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.seizure.2022.10.017_bib0001","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/ana.25619","article-title":"The genetic landscape of epilepsy of infancy with migrating focal seizures","volume":"86","author":"Burgess","year":"2019","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2022.10.017_bib0016","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41525-018-0052-9","article-title":"Incorporating epilepsy genetics into clinical practice: a 360 degrees evaluation","volume":"3","author":"Oates","year":"2018","journal-title":"NPJ Genom Med"},{"issue":"3","key":"10.1016\/j.seizure.2022.10.017_bib0017","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0026-895X(25)10372-6","article-title":"Oxidation of quinidine by human liver cytochrome P-450","volume":"30","author":"Guengerich","year":"1986","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.seizure.2022.10.017_bib0018","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2125.2005.02529.x","article-title":"Clinically relevant drug interactions with antiepileptic drugs","volume":"61","author":"Perucca","year":"2006","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.seizure.2022.10.017_bib0019","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1474-4422(19)30331-X","article-title":"Epilepsy genetics and the precision medicine matrix","volume":"19","author":"Sisodiya","year":"2020","journal-title":"Lancet Neurol"},{"issue":"8-9","key":"10.1016\/j.seizure.2022.10.017_bib0020","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/j.1552-4604.1982.tb02689.x","article-title":"Short- and long-term therapeutic efficacy of quinidine sulfate for the treatment of chronic ventricular arrhythmias","volume":"22","author":"Panidis","year":"1982","journal-title":"J Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.seizure.2022.10.017_bib0021","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0033-0620(77)90004-4","article-title":"Adverse reactions to quinidine in hospitalized patients: findings based on data from the boston collaborative drug surveillance program","volume":"20","author":"Cohen","year":"1977","journal-title":"Prog Cardiovasc Dis"},{"issue":"4","key":"10.1016\/j.seizure.2022.10.017_bib0022","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/epi.16480","article-title":"KCNT1-related epilepsy: an international multicenter cohort of 27 pediatric cases","volume":"61","author":"Borlot","year":"2020","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.seizure.2022.10.017_bib0023","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0022-3565(25)21198-3","article-title":"Quinidine preferentially blocks the slow delayed rectifier potassium channel in the rested state","volume":"279","author":"Yao","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.seizure.2022.10.017_bib0024","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1212\/WNL.0000000000004774","article-title":"Pitfalls in developing precision medicine for genetic epilepsy","volume":"90","author":"Meador","year":"2018","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.seizure.2022.10.017_bib0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2217\/pme.11.7","article-title":"The n-of-1 clinical trial: the ultimate strategy for individualizing medicine?","volume":"8","author":"Lillie","year":"2011","journal-title":"Per Med"},{"key":"10.1016\/j.seizure.2022.10.017_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107372","article-title":"Mapping epilepsy-specific patient-reported outcome measures for children to a proposed core outcome set for childhood epilepsy","volume":"112","author":"Crudgington","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2022.10.017_bib0027","doi-asserted-by":"crossref","DOI":"10.1038\/d41573-021-00085-9","article-title":"Clinical trial strategies for rare neurodevelopmental disorders: challenges and opportunities","author":"Krishnan","year":"2021","journal-title":"Nat Rev Drug Discov"}],"container-title":["Seizure: European Journal of Epilepsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131122002424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131122002424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T02:01:07Z","timestamp":1761012067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131122002424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":27,"alternative-id":["S1059131122002424"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2022.10.017","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intolerance to quinidine in a n-of-1 trial for KCNT1 associated epilepsy of infancy with migrating focal seizures","name":"articletitle","label":"Article Title"},{"value":"Seizure: European Journal of Epilepsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2022.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of British Epilepsy Association.","name":"copyright","label":"Copyright"}]}}