{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:04:17Z","timestamp":1780347857864,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","seizure-journal.com","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure: European Journal of Epilepsy"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.seizure.2023.06.016","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:31:35Z","timestamp":1687480295000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Early recognition of characteristic conventional and amplitude-integrated EEG patterns of seizures in SCN2A and KCNQ3-related epilepsy in neonates"],"prefix":"10.1016","volume":"110","author":[{"given":"Judith A.","family":"Pijpers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping Yee Billie","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Weeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla A.","family":"Vein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth S.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vilan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylke J.","family":"Steggerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Roberta","family":"Cilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Carapancea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Coralie","family":"Cornet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Appendino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cacha M.P.C.D.","family":"Peeters-Scholte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2023.06.016_bib0001","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.siny.2013.05.008","article-title":"Epidemiology and aetiology of neonatal seizures","volume":"18","author":"Vasudevan","year":"2013","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.seizure.2023.06.016_bib0002","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/epi.16815","article-title":"The ILAE classification of seizures and the epilepsies: modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures","volume":"62","author":"Pressler","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2023.06.016_bib0003","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/dmcn.12629","article-title":"The aetiology of neonatal seizures and the diagnostic contribution of neonatal cerebral magnetic resonance imaging","volume":"57","author":"Weeke","year":"2015","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.seizure.2023.06.016_bib0004","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.siny.2018.01.003","article-title":"Neonatal epilepsy genetics","volume":"23","author":"Axeen","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.seizure.2023.06.016_bib0005","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1212\/WNL.0000000000004284","article-title":"Profile of neonatal epilepsies: characteristics of a prospective US cohort","volume":"89","author":"Shellhaas","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2023.06.016_bib0006","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ajhg.2018.09.006","article-title":"De Novo pathogenic variants in CACNA1E cause developmental and epileptic encephalopathy with contractures, macrocephaly, and dyskinesias","volume":"103","author":"Helbig","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.seizure.2023.06.016_bib0007","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1212\/01.wnl.0000435296.72400.a1","article-title":"Extending the KCNQ2 encephalopathy spectrum: clinical and neuroimaging findings in 17 patients","volume":"81","author":"Weckhuysen","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2023.06.016_bib0008","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/brain\/awx054","article-title":"Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders","volume":"140","author":"Wolff","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.seizure.2023.06.016_bib0009","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1684\/epd.2018.1001","article-title":"Lacosamide for SCN2A-related intractable neonatal and infantile seizures","volume":"20","author":"Hadar","year":"2018","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.seizure.2023.06.016_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2019.02.001","article-title":"Antiepileptic therapy approaches in KCNQ2 related epilepsy: a systematic review","volume":"63","author":"Kuersten","year":"2020","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.seizure.2023.06.016_bib0011","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/brain\/awu042","article-title":"Seizure burden is independently associated with short term outcome in critically ill children","volume":"137","author":"Payne","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.seizure.2023.06.016_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107854","article-title":"Why we urgently need improved seizure and epilepsy therapies for children and neonates","volume":"170","author":"Pressler","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.seizure.2023.06.016_bib0013","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000478651","article-title":"A Distinctive ictal amplitude-integrated electroencephalography pattern in newborns with neonatal epilepsy associated with KCNQ2 mutations","volume":"112","author":"Vilan","year":"2017","journal-title":"Neonatology"},{"key":"10.1016\/j.seizure.2023.06.016_bib0014","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.seizure.2023.06.016_bib0015","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/epi.14074","article-title":"Diagnostic outcomes for genetic testing of 70 genes in 8565 patients with epilepsy and neurodevelopmental disorders","volume":"59","author":"Lindy","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2023.06.016_bib0016","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ng.2646","article-title":"Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1","volume":"45","author":"Carvill","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.seizure.2023.06.016_bib0017","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/epi4.12438","article-title":"Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I","volume":"5","author":"Maghera","year":"2020","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.seizure.2023.06.016_bib0018","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1152\/jn.00309.2021","article-title":"SCN2A -related epilepsy of infancy with migrating focal seizures: report of a variant with apparent gain- and loss-of-function effects","volume":"127","author":"Yang","year":"2022","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.seizure.2023.06.016_bib0019","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.dib.2018.08.122","article-title":"Data on mutations and Clinical features in SCN1A or SCN2A gene","volume":"22","author":"Kong","year":"2019","journal-title":"Data Brief"},{"key":"10.1016\/j.seizure.2023.06.016_bib0020","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1111\/epi.12554","article-title":"Exome sequencing identifies a de novo SCN2A mutation in a patient with intractable seizures, severe intellectual disability, optic atrophy, muscular hypotonia, and brain abnormalities","volume":"55","author":"Baasch","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2023.06.016_bib0021","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000448369","article-title":"Gene panel testing in epileptic encephalopathies and familial epilepsies","volume":"7","author":"M\u00f8ller","year":"2016","journal-title":"Mol Syndromol"},{"key":"10.1016\/j.seizure.2023.06.016_bib0022","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/brain\/awq057","article-title":"Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy","volume":"133","author":"Liao","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.seizure.2023.06.016_bib0023","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/epi.13596","article-title":"Rapid and safe response to low-dose carbamazepine in neonatal epilepsy","volume":"57","author":"Sands","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2023.06.016_bib0024","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/epi.12984","article-title":"Early and effective treatment of KCNQ2 encephalopathy","volume":"56","author":"Pisano","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2023.06.016_bib0025","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1542\/neo.7-2-e76","article-title":"Amplitude-integrated EEG classification and interpretation in preterm and term infants","volume":"7","author":"Hellstrom-Westas","year":"2006","journal-title":"Neoreviews"},{"key":"10.1016\/j.seizure.2023.06.016_bib0026","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.siny.2018.02.003","article-title":"Amplitude-integrated electroencephalography for seizure detection in newborn infants","volume":"23","author":"Hellstr\u00f6m-Westas","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.seizure.2023.06.016_bib0027","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/brain\/awf130","article-title":"The neuronal channelopathies","volume":"125","author":"Kullmann","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.seizure.2023.06.016_bib0028","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1097\/WNP.0000000000000974","article-title":"Tonic seizures in a patient with lennox\u2013gastaut syndrome manifest as \u201cIcicles\u201d rather than \u201cFlames\u201d on quantitative EEG analysis","volume":"40","author":"Catenaccio","year":"2023","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.seizure.2023.06.016_bib0029","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1111\/epi.16957","article-title":"Neonatal presentation of genetic epilepsies: early differentiation from acute provoked seizures","volume":"62","author":"Cornet","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2023.06.016_bib0030","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.1016\/j.jacr.2021.02.020","article-title":"ACR appropriateness criteria\u00ae seizures-child","volume":"18","author":"Trofimova","year":"2021","journal-title":"J Am Coll Radiol"},{"key":"10.1016\/j.seizure.2023.06.016_bib0031","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.3390\/ijms22084202","article-title":"Genetic neonatal-onset epilepsies and developmental\/epileptic encephalopathies with movement disorders: a systematic review","volume":"22","author":"Spagnoli","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.seizure.2023.06.016_bib0032","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/epi4.12104","article-title":"Epilepsy after perinatal stroke with different vascular subtypes","volume":"3","author":"Laugesaar","year":"2018","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.seizure.2023.06.016_bib0033","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/epi4.12353","article-title":"A novel homozygous KCNQ3 loss-of-function variant causes non-syndromic intellectual disability and neonatal-onset pharmacodependent epilepsy","volume":"4","author":"Lauritano","year":"2019","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.seizure.2023.06.016_bib0034","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.seizure.2018.05.005","article-title":"Diagnostic yield of targeted massively parallel sequencing in children with epileptic encephalopathy","volume":"59","author":"Kothur","year":"2018","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2023.06.016_bib0035","doi-asserted-by":"crossref","DOI":"10.1177\/1179573519849938","article-title":"Biallelic SCN2A gene mutation causing early infantile epileptic encephalopathy: case report and review","volume":"11","author":"AlSaif","year":"2019","journal-title":"J Cent Nerv Syst Dis"},{"key":"10.1016\/j.seizure.2023.06.016_bib0036","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/epi.16438","article-title":"Biological concepts in human sodium channel epilepsies and their relevance in clinical practice","volume":"61","author":"Brunklaus","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2023.06.016_bib0037","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12863-018-0628-5","article-title":"Genetic etiologies of the electrical status epilepticus during slow wave sleep: systematic review","volume":"19","author":"Kessi","year":"2018","journal-title":"BMC Genet"},{"key":"10.1016\/j.seizure.2023.06.016_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2015.08.001","article-title":"Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures","volume":"117","author":"Saitoh","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2023.06.016_bib0039","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-0-444-63326-2.00002-8","article-title":"Potassium channel genes and benign familial neonatal epilepsy","author":"Maljevic","year":"2014","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.seizure.2023.06.016_bib0040","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1523\/JNEUROSCI.4314-05.2006","article-title":"A common ankyrin-G-based mechanism retains KCNQ and Na V channels at electrically active domains of the axon","volume":"26","author":"Pan","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.seizure.2023.06.016_bib0041","doi-asserted-by":"crossref","first-page":"18577","DOI":"10.1073\/pnas.1209142109","article-title":"Modulation of voltage-gated K+ channels by the sodium channel 1 subunit","volume":"109","author":"Nguyen","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.seizure.2023.06.016_bib0042","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2021.1437","article-title":"Safety of early discontinuation of antiseizure medication after acute symptomatic neonatal seizures","author":"Glass","year":"2021","journal-title":"JAMA Neurol"}],"container-title":["Seizure: European Journal of Epilepsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131123001760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131123001760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T16:50:32Z","timestamp":1722617432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131123001760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":42,"alternative-id":["S1059131123001760"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2023.06.016","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early recognition of characteristic conventional and amplitude-integrated EEG patterns of seizures in SCN2A and KCNQ3-related epilepsy in neonates","name":"articletitle","label":"Article Title"},{"value":"Seizure: European Journal of Epilepsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2023.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of British Epilepsy Association.","name":"copyright","label":"Copyright"}]}}