{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:45:02Z","timestamp":1793108702560,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure: European Journal of Epilepsy"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.seizure.2025.06.005","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T19:14:46Z","timestamp":1749237286000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Maternal exposure to lamotrigine and the risk of orofacial clefts in offspring: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"131","author":[{"given":"Ze-lin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-ming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-ping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-qun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2025.06.005_bib0001","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.seizure.2025.06.005_bib0002","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1097\/SCS.0000000000003820","article-title":"Cleft lip and palate repair","volume":"28","author":"Gatti","year":"2017","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.seizure.2025.06.005_bib0003","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1097\/SCS.0000000000009591","article-title":"Global prevalence and burden of orofacial clefts: a systematic analysis for the global burden of disease study 2019","volume":"34","author":"Kantar","year":"2023","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.seizure.2025.06.005_bib0004","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0140-6736(24)02811-3","article-title":"Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"405","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.seizure.2025.06.005_bib0005","article-title":"Evaluating geographic distribution and potential environmental risk factors of orofacial cleft anomalies utilizing a statewide birth defects registry","author":"Kennedy","year":"2025","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.seizure.2025.06.005_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/genes14081603","article-title":"Orofacial clefts: genetics of cleft lip and palate","volume":"14","author":"Babai","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.seizure.2025.06.005_bib0007","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-79346-7","article-title":"Maternal factors increase risk of orofacial cleft: a meta-analysis","volume":"14","author":"\u00c1cs","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.seizure.2025.06.005_bib0008","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/14737175.2023.2176751","article-title":"Targeting adverse effects of antiseizure medication on offspring: current evidence and new strategies for safety","volume":"23","author":"Sha","year":"2023","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.seizure.2025.06.005_bib0009","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1111\/bcp.15752","article-title":"Antiseizure medication use during pregnancy and neonatal growth outcomes: a systematic review and meta-analysis","volume":"90","author":"Lavu","year":"2024","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.seizure.2025.06.005_bib0010","article-title":"The use of newer anti-seizure medicines in women with epilepsy in pregnancy: a case series","volume":"29","author":"Devin","year":"2025","journal-title":"Epilepsy Behav Rep"},{"key":"10.1016\/j.seizure.2025.06.005_bib0011","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s13311-016-0464-0","article-title":"Use of antiepileptic drugs during pregnancy: evolving concepts","volume":"13","author":"Pennell","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.seizure.2025.06.005_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031369","article-title":"Epilepsy in pregnancy-management principles and focus on valproate","volume":"23","author":"B\u0142aszczyk","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.seizure.2025.06.005_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD012065","article-title":"Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review","volume":"11","author":"Nolan","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.seizure.2025.06.005_bib0014","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1468-2982.2008.01571.x","article-title":"Anticonvulsants in migraine prophylaxis: a Cochrane review","volume":"28","author":"Mulleners","year":"2008","journal-title":"Cephalalgia"},{"key":"10.1016\/j.seizure.2025.06.005_bib0015","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/bdi.13452","article-title":"The efficacy of lamotrigine in bipolar disorder: a systematic review and meta-analysis","volume":"26","author":"Haenen","year":"2024","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.seizure.2025.06.005_bib0016","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1212\/WNL.0b013e3182574f39","article-title":"Comparative safety of antiepileptic drugs during pregnancy","volume":"78","author":"Hern\u00e1ndez-D\u00edaz","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2025.06.005_bib0017","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.annepidem.2011.08.002","article-title":"Use of antiepileptic medications in pregnancy in relation to risks of birth defects","volume":"21","author":"Werler","year":"2011","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.seizure.2025.06.005_bib0018","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1001\/jama.2011.624","article-title":"Newer-generation antiepileptic drugs and the risk of major birth defects","volume":"305","author":"M\u00f8lgaard-Nielsen","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.seizure.2025.06.005_bib0019","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1212\/WNL.0000000000002540","article-title":"Lamotrigine use in pregnancy and risk of orofacial cleft and other congenital anomalies","volume":"86","author":"Dolk","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2025.06.005_bib0020","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1212\/WNL.0000000000007696","article-title":"Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs","volume":"93","author":"Bloti\u00e8re","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2025.06.005_bib0021","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/ana.26561","article-title":"Comparative safety of antiseizure medication monotherapy for major malformations","volume":"93","author":"Cohen","year":"2023","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2025.06.005_bib0022","article-title":"Association of commonly prescribed antepartum medications and incidence of orofacial clefting","author":"Laspro","year":"2024","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.seizure.2025.06.005_bib0023","doi-asserted-by":"crossref","DOI":"10.1212\/CPJ.0000000000200289","article-title":"Specific birth defects following antiseizure medications used by pregnant women with epilepsy","volume":"14","author":"Wiggs","year":"2024","journal-title":"Neurol Clin Pract"},{"key":"10.1016\/j.seizure.2025.06.005_bib0024","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1212\/01.wnl.0000316194.98475.d8","article-title":"Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations?","volume":"71","author":"Dolk","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2025.06.005_bib0025","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1212\/01.wnl.0000304343.45104.d6","article-title":"Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy","volume":"70","author":"Holmes","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2025.06.005_bib0026","unstructured":"Higgins, J.P. Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane collaboration. Available at: https:\/\/cochrane-handbook.org\/. [6 December 2014]. 2014."},{"key":"10.1016\/j.seizure.2025.06.005_bib0027","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.seizure.2025.06.005_bib0028","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.seizure.2025.06.005_bib0029","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/j.1528-1167.2009.02130.x","volume":"50","author":"Harden","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2025.06.005_bib0030","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1124\/mol.111.072314","article-title":"Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects","volume":"80","author":"Tung","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.seizure.2025.06.005_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115352","article-title":"Effects of valproic acid, levetiracetam, carbamazepine, lamotrigine, and topiramate on LIF, E-cadherin, and FOXO1 mediator molecules in rat embryo implantation","volume":"199","author":"Kart","year":"2025","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.seizure.2025.06.005_bib0032","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0890-6238(01)00199-X","article-title":"The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures","volume":"16","author":"Matalon","year":"2002","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.seizure.2025.06.005_bib0033","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/cpt.158","article-title":"Risks of congenital malformations in offspring exposed to valproic acid in utero: a systematic review and cumulative meta-analysis","volume":"98","author":"Tanoshima","year":"2015","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.seizure.2025.06.005_bib0034","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.reprotox.2015.03.003","article-title":"First trimester exposure to topiramate and the risk of oral clefts in the offspring: a systematic review and meta-analysis","volume":"53","author":"Alsaad","year":"2015","journal-title":"Reprod Toxicol"}],"container-title":["Seizure: European Journal of Epilepsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131125001517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131125001517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:39:25Z","timestamp":1788244765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131125001517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":34,"alternative-id":["S1059131125001517"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2025.06.005","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal exposure to lamotrigine and the risk of orofacial clefts in offspring: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Seizure: European Journal of Epilepsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2025.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Epilepsy Association. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}