{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:26:24Z","timestamp":1793597184837,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia in Katowice","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010252","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["BNW-1-180\/K\/4\/K"],"award-info":[{"award-number":["BNW-1-180\/K\/4\/K"]}],"id":[{"id":"10.13039\/501100010252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure: European Journal of Epilepsy"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.seizure.2025.08.030","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T23:26:31Z","timestamp":1756250791000},"page":"98-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Tough to treat: What we know about managing PCDH19-related epilepsy - Systematic review"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1788-3404","authenticated-orcid":false,"given":"Aleksandra","family":"Tobiasz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Hager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"D\u0119bowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Jaunich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-8546","authenticated-orcid":false,"given":"Justyna","family":"Paprocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.seizure.2025.08.030_bib0001","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1007\/s00018-005-5320-z","article-title":"Delta-protocadherins: unique structures and functions","volume":"62","author":"Redies","year":"2005","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"10.1016\/j.seizure.2025.08.030_bib0002","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4103\/1673-5374.322455","article-title":"PCDH19 interplay with GABA(A) receptors: a window to DEE9 pathogenetic mechanisms","volume":"17","author":"Mazzoleni","year":"2022","journal-title":"Neural Regen Res"},{"issue":"6","key":"10.1016\/j.seizure.2025.08.030_bib0003","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ng.149","article-title":"X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment","volume":"40","author":"Dibbens","year":"2008","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.seizure.2025.08.030_bib0004","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/dneu.22654","article-title":"The role of protocadherin 19 (PCDH19) in neurodevelopment and in the pathophysiology of early infantile epileptic encephalopathy-9 (EIEE9)","volume":"79","author":"Gerosa","year":"2019","journal-title":"Dev Neurobiol"},{"issue":"1","key":"10.1016\/j.seizure.2025.08.030_bib0005","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000200233","article-title":"Women with genetic epilepsies","volume":"11","author":"Marques","year":"2025","journal-title":"Neurol Genet"},{"key":"10.1016\/j.seizure.2025.08.030_bib0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pediatrneurol.2019.10.009","article-title":"PCDH19-related epilepsy syndrome: a comprehensive clinical review","volume":"105","author":"Samanta","year":"2020","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.seizure.2025.08.030_bib0007","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18529","article-title":"Structural determinants of adhesion by protocadherin-19 and implications for its role in epilepsy","volume":"5","author":"Cooper","year":"2016","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.seizure.2025.08.030_bib0008","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12881-018-0621-x","article-title":"Chinese cases of early infantile epileptic encephalopathy: a novel mutation in the PCDH19 gene was proved in a mosaic male- case report","volume":"19","author":"Tan","year":"2018","journal-title":"BMC Med Genet"},{"issue":"2","key":"10.1016\/j.seizure.2025.08.030_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000381","article-title":"Sporadic infantile epileptic encephalopathy caused by mutations in PCDH19 resembles Dravet syndrome but mainly affects females","volume":"5","author":"Depienne","year":"2009","journal-title":"PLoS Genet"},{"issue":"6","key":"10.1016\/j.seizure.2025.08.030_bib0010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1684\/epd.2018.1009","article-title":"Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation","volume":"20","author":"Chemaly","year":"2018","journal-title":"Epileptic Disord"},{"issue":"6","key":"10.1016\/j.seizure.2025.08.030_bib0011","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s10038-020-00880-z","article-title":"Comparative characterization of PCDH19 missense and truncating variants in PCDH19-related epilepsy","volume":"66","author":"Shibata","year":"2021","journal-title":"J Hum Genet"},{"issue":"12","key":"10.1016\/j.seizure.2025.08.030_bib0012","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1111\/epi.14600","article-title":"Defining the electroclinical phenotype and outcome of PCDH19-related epilepsy: a multicenter study","volume":"59","author":"Trivisano","year":"2018","journal-title":"Epilepsia"},{"issue":"12","key":"10.1016\/j.seizure.2025.08.030_bib0013","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1111\/j.1528-1167.2012.03649.x","article-title":"Focal seizures with affective symptoms are a major feature of PCDH19 gene-related epilepsy","volume":"53","author":"Marini","year":"2012","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.seizure.2025.08.030_bib0014","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/epd2.20264","article-title":"Multicenter retrospective study of patients with PCDH19-related epilepsy: the first Hungarian cohort","volume":"26","author":"Kovacs","year":"2024","journal-title":"Epileptic Disord"},{"issue":"1-2","key":"10.1016\/j.seizure.2025.08.030_bib0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.eplepsyres.2013.04.005","article-title":"PCDH19-related female-limited epilepsy: further details regarding early clinical features and therapeutic efficacy","volume":"106","author":"Higurashi","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2025.08.030_bib0016","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.seizure.2016.01.006","article-title":"Effectiveness of antiepileptic therapy in patients with PCDH19 mutations","volume":"35","author":"Lotte","year":"2016","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.seizure.2025.08.030_bib0017","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12920-022-01313-w","article-title":"Expanding the genetic and clinical characteristics of Protocadherin 19 gene mutations","volume":"15","author":"Dell'Isola","year":"2022","journal-title":"BMC Med Genom"},{"issue":"2","key":"10.1016\/j.seizure.2025.08.030_bib0018","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejpn.2014.11.008","article-title":"Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy","volume":"19","author":"Trivisano","year":"2015","journal-title":"Eur J Paediatr Neurol"},{"issue":"5","key":"10.1016\/j.seizure.2025.08.030_bib0019","doi-asserted-by":"crossref","first-page":"761","DOI":"10.32641\/rchped.v91i5.1490","article-title":"Pathogenic variant in the PCDH19 gene in a patient with epilepsy and cognitive disability. Variante patog\u00e9nica en el gen PCDH19 en una paciente con epilepsia y discapacidad cognitiva","volume":"91","author":"Venegas Silva","year":"2020","journal-title":"Rev Chil Pediatr"},{"key":"10.1016\/j.seizure.2025.08.030_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.seizure.2024.07.023","article-title":"Phenotypic and genotypic characteristics of children with PCDH19 clustering epilepsy in China","volume":"121","author":"Feng","year":"2024","journal-title":"Seizure"},{"issue":"2","key":"10.1016\/j.seizure.2025.08.030_bib0021","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000041211","article-title":"Abdominal pain as a novel manifestation in children with PCDH19-related epilepsy: a case report","volume":"104","author":"Hu","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.seizure.2025.08.030_bib0022","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejpn.2019.12.020","article-title":"Levetiracetam efficacy in PCDH19 girls clustering epilepsy","volume":"24","author":"Sadleir","year":"2020","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.seizure.2025.08.030_bib0023","article-title":"Behavioral and neuropsychological profile of a male patient with mosaic PCDH19 mutation","volume":"19","author":"Johannessen","year":"2022","journal-title":"Epilepsy Behav Rep"},{"issue":"2","key":"10.1016\/j.seizure.2025.08.030_bib0024","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000535144","article-title":"A male child with infantile epilepsy due to a mosaic missense variant of PCDH19","volume":"15","author":"Parmeggiani","year":"2024","journal-title":"Mol Syndromol"},{"issue":"4","key":"10.1016\/j.seizure.2025.08.030_bib0025","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/practneurol-2016-001521","article-title":"PCDH19-related epilepsy: a rare but recognisable clinical syndrome in females","volume":"17","author":"Lyons","year":"2017","journal-title":"Pract Neurol"},{"issue":"3","key":"10.1016\/j.seizure.2025.08.030_bib0026","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.pedneo.2024.04.011","article-title":"Dravet-like syndrome with PCDH19 mutations in Taiwan - a multicenter study","volume":"66","author":"Liu","year":"2025","journal-title":"Pediatr Neonatol"},{"issue":"6","key":"10.1016\/j.seizure.2025.08.030_bib0027","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/dmcn.15803","article-title":"Seizure course of PCDH19 clustering epilepsy in female children: a multicentre cohort study in China","volume":"66","author":"Chen","year":"2024","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.seizure.2025.08.030_bib0028","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.seizure.2023.03.017","article-title":"Levetiracetam, from broad-spectrum use to precision prescription: a narrative review and expert opinion","volume":"107","author":"Celdran de Castro","year":"2023","journal-title":"Seizure"},{"issue":"8","key":"10.1016\/j.seizure.2025.08.030_bib0029","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1528-1157.1995.tb01617.x","article-title":"Clobazam in long-term epilepsy treatment: sustained responders versus those developing tolerance","volume":"36","author":"Singh","year":"1995","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.seizure.2025.08.030_bib0030","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1007\/s12325-023-02586-y","article-title":"Narrative review of topiramate: clinical uses and pharmacological considerations","volume":"40","author":"Pearl","year":"2023","journal-title":"Adv Ther"},{"issue":"8","key":"10.1016\/j.seizure.2025.08.030_bib0031","first-page":"1334","article-title":"Genotype-phenotype analysis of children with epilepsy referred for whole-exome sequencing at a tertiary care university hospital","volume":"10","author":"Bashiri","year":"2023","journal-title":"Child (Basel Switz)"},{"issue":"1","key":"10.1016\/j.seizure.2025.08.030_bib0032","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuropharm.2008.06.004","article-title":"The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator","volume":"56","author":"Fisher","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.seizure.2025.08.030_bib0033","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.seizure.2020.06.007","article-title":"Antiseizure medication withdrawal in seizure-free patients with PCDH19-related epilepsy: a multinational cohort survey","volume":"80","author":"Aledo-Serrano","year":"2020","journal-title":"Seizure"},{"issue":"Pt 2","key":"10.1016\/j.seizure.2025.08.030_bib0034","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1113\/jphysiol.2006.106385","article-title":"Glucocorticoid effects on mouse microvascular endothelial barrier permeability are brain specific","volume":"573","author":"F\u00f6rster","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.seizure.2025.08.030_bib0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.seizure.2015.09.002","article-title":"Steroids efficacy in the acute management of seizure clusters in one case of PCDH19 female epilepsy","volume":"32","author":"Bertani","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2025.08.030_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.seizure.2015.02.006","article-title":"Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy","volume":"27","author":"Higurashi","year":"2015","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.seizure.2025.08.030_bib0037","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/14728214.2022.2059464","article-title":"Epilepsy: expert opinion on emerging drugs in phase 2\/3 clinical trials","volume":"27","author":"PPong","year":"2022","journal-title":"Expert Opin Emerg Drugs"},{"issue":"18","key":"10.1016\/j.seizure.2025.08.030_bib0038","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1093\/hmg\/ddv245","article-title":"Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency","volume":"24","author":"Tan","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.seizure.2025.08.030_bib0039","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1111\/epi.13772","article-title":"Reduced steroidogenesis in patients with PCDH19-female limited epilepsy","volume":"58","author":"Trivisano","year":"2017","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.seizure.2025.08.030_bib0040","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/15357597221125238","article-title":"Ganaxolone: a new treatment for CDKL5 deficiency disorder","volume":"22","author":"Vossler","year":"2022","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.seizure.2025.08.030_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2023.107112","article-title":"Phase 2, placebo-controlled clinical study of oral ganaxolone in PCDH19-clustering epilepsy","volume":"191","author":"Sullivan","year":"2023","journal-title":"Epilepsy Res"},{"issue":"20","key":"10.1016\/j.seizure.2025.08.030_bib0042","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015400","article-title":"Antiepileptogenic effects of anakinra, lamotrigine and their combination in a lithium-pilocarpine model of temporal lobe epilepsy in rats","volume":"24","author":"Zubareva","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.seizure.2025.08.030_bib0043","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1212\/WNL.0000000000200855","article-title":"Child neurology: initial presentation of PCDH19-related epilepsy with new-onset refractory status epilepticus and treatment with anakinra","volume":"99","author":"Varughese","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2025.08.030_bib0044","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.eplepsyres.2016.08.001","article-title":"Safety, efficacy and outcome-related factors of perampanel over 12 months in a real-world setting: the FYDATA study","volume":"126","author":"Villanueva","year":"2016","journal-title":"Epilepsy Res"},{"issue":"6","key":"10.1016\/j.seizure.2025.08.030_bib0045","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/acn3.51030","article-title":"Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition","volume":"7","author":"Wright","year":"2020","journal-title":"Ann Clin Transl Neurol"},{"issue":"4","key":"10.1016\/j.seizure.2025.08.030_bib0046","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/epi.17530","article-title":"Perampanel as precision therapy in rare genetic epilepsies","volume":"64","author":"Nissenkorn","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2025.08.030_bib0047","unstructured":"U.S. Food and Drug Administration. (2017). PMA approval for VNS therapy system (P970003S207). FDA. https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfpma\/pma.cfm?id=P970003S207."},{"key":"10.1016\/j.seizure.2025.08.030_bib0048","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neulet.2015.07.034","article-title":"How does the ketogenic diet induce anti-seizure effects?","volume":"637","author":"Rho","year":"2017","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1016\/j.seizure.2025.08.030_bib0049","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/epi4.12225","article-title":"Optimal clinical management of children receiving dietary therapies for epilepsy: updated recommendations of the international ketogenic diet study group","volume":"3","author":"Kossoff","year":"2018","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.seizure.2025.08.030_bib0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.seizure.2016.07.006","article-title":"Ketogenic diet treatment for pediatric super-refractory status epilepticus","volume":"41","author":"Appavu","year":"2016","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2025.08.030_bib0051","article-title":"Efficacy of ketogenic diet for infantile spasms in Chinese patients with or without monogenic etiology","volume":"10","author":"Wang","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.seizure.2025.08.030_bib0052","series-title":"Complications in neurosurgery","first-page":"196","article-title":"Complications after epilepsy surgery","author":"Mansfield","year":"2019"},{"key":"10.1016\/j.seizure.2025.08.030_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109517","article-title":"Epilepsy surgery as a treatment option for select patients with PCDH19-related epilepsy","volume":"149","author":"Simmons","year":"2023","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2025.08.030_bib0054","article-title":"Epilepsy surgery in PCDH 19 related developmental and epileptic encephalopathy: a case report","volume":"19","author":"Nagarajan","year":"2022","journal-title":"Epilepsy Behav Rep"}],"container-title":["Seizure: European Journal of Epilepsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131125002250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131125002250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:28:41Z","timestamp":1793593721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131125002250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":54,"alternative-id":["S1059131125002250"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2025.08.030","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tough to treat: What we know about managing PCDH19-related epilepsy - Systematic review","name":"articletitle","label":"Article Title"},{"value":"Seizure: European Journal of Epilepsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2025.08.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of British Epilepsy Association.","name":"copyright","label":"Copyright"}]}}