{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:26:23Z","timestamp":1793597183016,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["18PTC-19\\u2013602,325"],"award-info":[{"award-number":["18PTC-19\\u2013602,325"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["84,166"],"award-info":[{"award-number":["84,166"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018841","name":"Associazione Italiana Ricerca Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018841","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure: European Journal of Epilepsy"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.seizure.2025.09.002","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T06:53:22Z","timestamp":1756882402000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Angiotensin receptor blockers (ARBs) reduce the risk of developing epilepsy in patients with ischemic stroke and hypertension"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-5345","authenticated-orcid":false,"given":"Giacomo","family":"Evangelista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedele","family":"Dono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Melchiorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Corniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Liviello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Quintieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina Di","family":"Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9371-8035","authenticated-orcid":false,"given":"Catello","family":"Vollono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano L.","family":"Sensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2025.09.002_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1273270","article-title":"Post-stroke seizures, epilepsy, and mortality in a prospective hospital-based study","volume":"14","author":"Freiman","year":"2023","journal-title":"Front Neurol"},{"issue":"2","key":"10.1016\/j.seizure.2025.09.002_bib0002","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/2396987317705536","article-title":"European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy","volume":"2","author":"Holtkamp","year":"2017","journal-title":"Eur Stroke J"},{"issue":"7","key":"10.1016\/j.seizure.2025.09.002_bib0003","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1161\/01.STR.0000130989.17100.96","article-title":"Seizures and epilepsy after ischemic stroke","volume":"35","author":"Camilo","year":"2004","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.seizure.2025.09.002_bib0004","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s10072-019-03913-4","article-title":"Epilepsy Study Group of the Italian Neurological Society. Hypertension, seizures, and epilepsy: a review on pathophysiology and management","volume":"40","author":"Gasparini","year":"2019","journal-title":"Neurol Sci"},{"issue":"2","key":"10.1016\/j.seizure.2025.09.002_bib0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.43.2.425","article-title":"Hypertension and the risk of new-onset unprovoked seizures","volume":"43","author":"Ng","year":"1993","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.seizure.2025.09.002_bib0006","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10571-015-0278-3","article-title":"Long-term treatment with losartan attenuates seizure activity and neuronal damage without affecting behavioral changes in a model of co-morbid hypertension and epilepsy","volume":"36","author":"Tchekalarova","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.seizure.2025.09.002_bib0007","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fneur.2019.00501","article-title":"Blood pressure in seizures and epilepsy","volume":"10","author":"Nass","year":"2019","journal-title":"Front Neurol"},{"issue":"33","key":"10.1016\/j.seizure.2025.09.002_bib0008","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"issue":"10","key":"10.1016\/j.seizure.2025.09.002_bib0009","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1097\/HJH.0000000000001940","volume":"36","author":"Williams","year":"2018","journal-title":"J Hypertens"},{"issue":"6","key":"10.1016\/j.seizure.2025.09.002_bib0010","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1476-5381.2010.00750.x","article-title":"Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status","volume":"160","author":"Ma","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.seizure.2025.09.002_bib0011","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/ijms20030726","article-title":"Role of the angiotensin pathway and its target therapy in epilepsy management","volume":"20","author":"Krasniqi","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.seizure.2025.09.002_bib0012","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/jamaneurol.2022.3413","article-title":"Association between Angiotensin receptor blocker therapy and incidence of epilepsy in patients with hypertension","volume":"79","author":"Doege","year":"2022","journal-title":"JAMA Neurol"},{"issue":"1","key":"10.1016\/j.seizure.2025.09.002_bib0013","doi-asserted-by":"crossref","first-page":"I","DOI":"10.1177\/2396987321989865","article-title":"European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke","volume":"6","author":"Berge","year":"2021","journal-title":"Eur Stroke J"},{"issue":"8","key":"10.1016\/j.seizure.2025.09.002_bib0014","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1136\/neurintsurg-2018-014569","article-title":"European Stroke Organisation (ESO) - European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on mechanical thrombectomy in acute ischemic Stroke","volume":"15","author":"Turc","year":"2023","journal-title":"J Neurointerv Surg"},{"issue":"1","key":"10.1016\/j.seizure.2025.09.002_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Marsh EE 3rd. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in acute stroke treatment","volume":"24","author":"Jr","year":"1993","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.seizure.2025.09.002_bib0016","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1474-4422(17)30404-0","article-title":"Prediction of late seizures after ischaemic stroke with a novel prognostic model (the SeLECT score): a multivariable prediction model development and validation study","volume":"17","author":"Galovic","year":"2018","journal-title":"Lancet Neurol"},{"issue":"11","key":"10.1016\/j.seizure.2025.09.002_bib0017","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jamaneurol.2018.1935","article-title":"Association between midlife risk factors and late-onset epilepsy: results from the atheroscle- rosis risk in communities study","volume":"75","author":"Johnson","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.seizure.2025.09.002_bib0018","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1528-1167.2008.01581.x","article-title":"The renin- angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis","volume":"49","author":"Arganaraz","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2025.09.002_bib0019","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.43.2.425","article-title":"Hypertension and the risk of new-onset unprovoked seizures","volume":"43","author":"Ng","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2025.09.002_bib0020","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1528-1157.1997.tb01219.x","article-title":"Vascular determi- nants of epilepsy: the Rotterdam Study","volume":"38","author":"Li","year":"1997","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.seizure.2025.09.002_bib0021","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1528-1157.1996.tb00644.x","article-title":"Severe, uncontrolled hypertension and adult-onset seizures: a case-control study in Rochester, Minnesota","volume":"37","author":"Hesdorffer","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2025.09.002_bib0022","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0896-6974(98)00029-2","article-title":"The phenomenology of sei- zures and epilepsy after stroke","volume":"11","author":"Lambrakis","year":"1998","journal-title":"J Epilepsy"},{"issue":"8","key":"10.1016\/j.seizure.2025.09.002_bib0023","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/epi.13448","article-title":"Epilepsy Study Group of the Italian Neurological Society. Epilepsy in cerebrovascular diseases: review of experimental and clinical data with meta-analysis of risk factors","volume":"57","author":"Ferlazzo","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2025.09.002_bib0024","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fncel.2020.00051","article-title":"Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells","volume":"14","author":"Belov Kirdajova","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"10.1016\/j.seizure.2025.09.002_bib0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.seizure.2025.09.002_bib0026","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1038\/s41467-018-07318-3","article-title":"Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension","volume":"9","author":"Mestre","year":"2018","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.seizure.2025.09.002_bib0027","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1111\/ene.15792","article-title":"Heart rate variability modification as a predictive factor of sudden unexpected death in epilepsy: how far are we? A systematic review and meta-analysis","volume":"30","author":"Evangelista","year":"2023","journal-title":"Eur J Neurol"},{"issue":"7 Suppl 4","key":"10.1016\/j.seizure.2025.09.002_bib0028","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00005344-200000004-00001","article-title":"Sympathetic nervous system activation in essential hypertension, cardiac failure and psychosomatic heart disease","volume":"35","author":"Esler","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"10.1016\/j.seizure.2025.09.002_bib0029","doi-asserted-by":"crossref","first-page":"E726","DOI":"10.3390\/ijms20030726","article-title":"Role of the angiotensin pathway and its target therapy in epilepsy management","volume":"20","author":"Krasniqi","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.seizure.2025.09.002_bib0030","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders","volume":"123","author":"Saavedra","year":"2012","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"10.1016\/j.seizure.2025.09.002_bib0031","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ana.24147","article-title":"Losartan prevents acquired epilepsy via TGF-\u03b2 signaling suppression","volume":"75","author":"Bar-Klein","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2025.09.002_bib0032","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pbb.2014.10.005","article-title":"Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy","volume":"127","author":"Tchekalarova","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.seizure.2025.09.002_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2020.107230","article-title":"The role of l-type calcium channels in neuronal excitability and aging","volume":"173","author":"Moore","year":"2020","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"10.1016\/j.seizure.2025.09.002_bib0034","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/lm.88805","article-title":"The l-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice","volume":"12","author":"Cain","year":"2005","journal-title":"Learn Mem"},{"issue":"5264","key":"10.1016\/j.seizure.2025.09.002_bib0035","first-page":"1017","article-title":"Increase in single l-type calcium channels in hippocampal neurons during aging","volume":"272","author":"Thibault","year":"1996","journal-title":"Science (1979)"},{"issue":"2","key":"10.1016\/j.seizure.2025.09.002_bib0036","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0169-328X(02)00643-5","article-title":"Age-related working memory impairment is correlated with increases in the l-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment","volume":"110","author":"Veng","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.seizure.2025.09.002_bib0037","first-page":"2","article-title":"Learning and aging related changes in intrinsic neuronal excitability","volume":"2","author":"Oh","year":"2010","journal-title":"Front Aging Neurosci"},{"issue":"971","key":"10.1016\/j.seizure.2025.09.002_bib0038","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/pgmj.2005.041426","article-title":"Post-stroke seizure and post-stroke epilepsy","volume":"82","author":"Myint","year":"2006","journal-title":"Postgrad Med J"},{"issue":"10","key":"10.1016\/j.seizure.2025.09.002_bib0039","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.3390\/molecules26102838","article-title":"The effects of statins on neurotransmission and their neuroprotective role in neurological and psychiatric disorders","volume":"26","author":"Kosowski","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.seizure.2025.09.002_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107400","article-title":"Statins in primary prevention of poststroke seizures and epilepsy: a systematic review","volume":"112","author":"Nucera","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2025.09.002_bib0041","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6234758","article-title":"The effect of metformin in experimentally induced animal models of epileptic seizure","author":"Yimer","year":"2019","journal-title":"Behav Neurol"},{"issue":"1","key":"10.1016\/j.seizure.2025.09.002_bib0042","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yebeh.2012.12.031","article-title":"Does aspirin use make it harder to collect seizures during elective video-EEG telemetry?","volume":"27","author":"Godfred","year":"2013","journal-title":"Epilepsy Behav"},{"issue":"8","key":"10.1016\/j.seizure.2025.09.002_bib0043","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1080\/01616412.2017.1326657","article-title":"Aspirin attenuates spontaneous recurrent seizures in the chronically epileptic mice","volume":"39","author":"Zhu","year":"2017","journal-title":"Neurol Res"},{"key":"10.1016\/j.seizure.2025.09.002_bib0044","article-title":"Diagnostic and therapeutic value of P2Y12R in epilepsy","volume":"14","author":"Chen","year":"2023","journal-title":"Front Pharmacol"}],"container-title":["Seizure: European Journal of Epilepsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131125002377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131125002377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:28:16Z","timestamp":1793593696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131125002377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":44,"alternative-id":["S1059131125002377"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2025.09.002","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin receptor blockers (ARBs) reduce the risk of developing epilepsy in patients with ischemic stroke and hypertension","name":"articletitle","label":"Article Title"},{"value":"Seizure: European Journal of Epilepsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2025.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of British Epilepsy Association.","name":"copyright","label":"Copyright"}]}}