{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:08:15Z","timestamp":1778800095835,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure: European Journal of Epilepsy"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.seizure.2026.03.014","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:21:22Z","timestamp":1774545682000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy and tolerability of felbamate in adults with severe intellectual and developmental disabilities and drug-resistant epilepsy: A single-center evaluation"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8184-3961","authenticated-orcid":false,"given":"D.","family":"Stankewitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.seizure.2026.03.014_bib0001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.seizure.2015.03.016","article-title":"Prevalence of epilepsy among people with intellectual disabilities: a systematic review","volume":"29","author":"Robertson","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2026.03.014_bib0002","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/1098-2779(2000)6:4<309::AID-MRDD10>3.0.CO;2-I","article-title":"Treatment of epilepsy in the multiply handicapped","volume":"6","author":"Pellock","year":"2000","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.1016\/j.seizure.2026.03.014_bib0003","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1528-1157.1995.tb01061.x","article-title":"Sudden death in epilepsy: a study of incidence in a young cohort with epilepsy and learning difficulty","volume":"36","author":"Nashef","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2026.03.014_bib0004","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yebeh.2003.10.016","article-title":"Pharmacological outcomes in people with mental retardation and epilepsy","volume":"5","author":"Kelly","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2026.03.014_bib0005","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJM200002033420503","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Kwan","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.seizure.2026.03.014_bib0006","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1177\/106002809302700913","article-title":"Felbamate","volume":"27","author":"Graves","year":"1993","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.seizure.2026.03.014_bib0007","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eplepsyres.2006.06.020","article-title":"Felbamate: Consensus of current clinical experience","volume":"71","author":"Pellock","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2026.03.014_bib0008","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.41.11.1785","article-title":"Felbamate for partial seizures: results of a controlled clinical trial","volume":"41","author":"Leppik","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2026.03.014_bib0009","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1528-1157.1991.tb04668.x","article-title":"Felbamate: a clinical trial for complex partial seizures","volume":"32","author":"Theodore","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2026.03.014_bib0010","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ana.410320313","article-title":"Felbamate monotherapy: controlled trial in patients with partial onset seizures","volume":"32","author":"Sachdeo","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.seizure.2026.03.014_bib0011","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2165\/00002018-199921030-00006","article-title":"Felbamate in epilepsy therapy: evaluating the risks","volume":"21","author":"Pellock","year":"1999","journal-title":"Drug Saf"},{"key":"10.1016\/j.seizure.2026.03.014_bib0012","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies: definition of drug resistant epilepsy","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2026.03.014_bib0013","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.seizure.2020.03.004","article-title":"Position paper of a German interdisciplinary round table on future designs of trials on adjunctive treatment with antiseizure drugs","volume":"78","author":"Hamer","year":"2020","journal-title":"Seizure"},{"key":"10.1016\/j.seizure.2026.03.014_bib0014","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2165\/00023210-199504060-00004","article-title":"Clozapine-induced agranulocytosis: risk factors, monitoring and management","volume":"4","author":"Mendelowitz","year":"1995","journal-title":"CNS Drugs"},{"key":"10.1016\/j.seizure.2026.03.014_bib0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0920-1211(96)00070-8","article-title":"Felbamate in therapy-resistant epilepsy: an Italian experience","volume":"25","author":"Avanzini","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2026.03.014_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-1211(01)00290-X","article-title":"The long-term use of felbamate in children with severe refractory epilepsy","volume":"47","author":"Cilio","year":"2001","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2026.03.014_bib0017","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1111\/j.1528-1167.2009.02187.x","article-title":"Long-term use of felbamate: clinical outcomes and effect of age and concomitant antiepileptic drug use on its clearance","volume":"50","author":"White","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2026.03.014_bib0018","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.pediatrneurol.2010.02.013","article-title":"Efficacy of felbamate in the treatment of intractable pediatric epilepsy","volume":"42","author":"Zupanc","year":"2010","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.seizure.2026.03.014_bib0019","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.ejpn.2014.05.005","article-title":"Efficacy and safety of felbamate in children with refractory epilepsy","volume":"18","author":"Heyman","year":"2014","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.seizure.2026.03.014_bib0020","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.yebeh.2016.01.006","article-title":"Evaluating the safety and efficacy of felbamate in the context of a black box warning: a single center experience","volume":"56","author":"Shah","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.seizure.2026.03.014_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.979725","article-title":"Felbamate for pediatric epilepsy\u2014should we keep on using it as the last resort?","volume":"13","author":"Rabinowicz","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.seizure.2026.03.014_bib0022","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0920-1211(98)00098-9","article-title":"Felbamate in refractory partial epilepsy","volume":"34","author":"Canger","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.seizure.2026.03.014_bib0023","first-page":"146","article-title":"Felbamate as add-on therapy","volume":"36","author":"Li","year":"1996","journal-title":"Eur Neurol"},{"key":"10.1016\/j.seizure.2026.03.014_bib0024","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.43.4.693","article-title":"Felbamate: a double-blind controlled trial in patients undergoing presurgical evaluation of partial seizures","volume":"43","author":"Bourgeois","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2026.03.014_bib0025","first-page":"106","article-title":"Felbamate as add-on therapy in adult patients with partial drug- resistant epilepsy","author":"Binelli","year":"1999","journal-title":"Bollettino - Lega Italiana Contro l\u2019Epilessia"},{"key":"10.1016\/j.seizure.2026.03.014_bib0026","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/jnnp.64.2.231","article-title":"Epileptic drop attacks in partial epilepsy: clinical features, evolution, and prognosis","volume":"64","author":"Tinuper","year":"1998","journal-title":"J Neurol, Neurosurg Psychiatry"},{"key":"10.1016\/j.seizure.2026.03.014_bib0027","article-title":"Felbamate in the treatment of Lennox-Gastaut syndrome: results of a 12-month open-label study following a randomized clinical trial","volume":"34","author":"WEdwin","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.seizure.2026.03.014_bib0028","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1056\/NEJM199301073280105","article-title":"Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut Syndrome)","volume":"328","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.seizure.2026.03.014_bib0029","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.pediatrneurol.2015.07.007","article-title":"Successful treatment of electrographic status epilepticus of sleep with felbamate in a patient with SLC9A6 mutation","volume":"53","author":"Coorg","year":"2015","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.seizure.2026.03.014_bib0030","first-page":"1","article-title":"A potential role for felbamate in TSC- and NF1-related epilepsy: a case report and review of the literature. Case reports in neurological","volume":"2015","author":"Mishal","year":"2015","journal-title":"Medicine"}],"container-title":["Seizure: European Journal of Epilepsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131126000798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131126000798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:20:56Z","timestamp":1778797256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131126000798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"alternative-id":["S1059131126000798"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2026.03.014","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and tolerability of felbamate in adults with severe intellectual and developmental disabilities and drug-resistant epilepsy: A single-center evaluation","name":"articletitle","label":"Article Title"},{"value":"Seizure: European Journal of Epilepsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2026.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 British Epilepsy Association. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}