{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:01:46Z","timestamp":1789916506663,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure: European Journal of Epilepsy"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.seizure.2026.06.010","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:48:58Z","timestamp":1781884138000},"page":"6-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy, tolerability, and EEG lateralization-based predictors of neuropsychiatric adverse events in pediatric SeLECTS treated with perampanel monotherapy"],"prefix":"10.1016","volume":"141","author":[{"given":"Yaping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.seizure.2026.06.010_bib0001","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/epi.17241","article-title":"International league against epilepsy classification and definition of epilepsy syndromes with onset in childhood: position paper by the ILAE task force on nosology and definitions","volume":"63","author":"Specchio","year":"2022","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.seizure.2026.06.010_bib0002","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1528-1167.2006.00695.x","article-title":"Neuropsychological findings in Rolandic epilepsy and Landau-Kleffner syndrome","volume":"47","author":"Metz-Lutz","year":"2006","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.seizure.2026.06.010_bib0003","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/epi.13054","article-title":"Psychiatric and behavioral adverse events in randomized clinical studies of the noncompetitive AMPA receptor antagonist perampanel","volume":"56","author":"Ettinger","year":"2015","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.seizure.2026.06.010_bib0004","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/S1388-2457(00)00408-9","article-title":"Encephalopathy with electrical status epilepticus during slow sleep or ESES syndrome including the acquired aphasia","volume":"111","author":"Tassinari","year":"2000","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.seizure.2026.06.010_bib0005","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1528-1167.2011.03371.x","article-title":"A neurocognitive endophenotype associated with Rolandic epilepsy","volume":"53","author":"Smith","year":"2012","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0006","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/epd2.20003","article-title":"WISC-IV intellectual profiles in Italian children with self-limited epilepsy with centrotemporal spikes","volume":"25","author":"Zanaboni","year":"2023","journal-title":"Epileptic Disord"},{"issue":"3","key":"10.1016\/j.seizure.2026.06.010_bib0007","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/epi.12074","article-title":"Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes","volume":"54","author":"Glauser","year":"2013","journal-title":"Epilepsia"},{"issue":"14","key":"10.1016\/j.seizure.2026.06.010_bib0008","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s40265-015-0465-z","article-title":"Perampanel: a review in drug-resistant epilepsy","volume":"75","author":"Frampton","year":"2015","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.seizure.2026.06.010_bib0009","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00415-021-10751-y","article-title":"PERMIT study: a global pooled analysis study of the effectiveness and tolerability of perampanel in routine clinical practice","volume":"269","author":"Villanueva","year":"2022","journal-title":"J Neurol"},{"key":"10.1016\/j.seizure.2026.06.010_bib0010","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejpn.2024.02.008","article-title":"Phase IV PROVE study: perampanel in real-world clinical care of pediatric patients with epilepsy","volume":"50","author":"Moretz","year":"2024","journal-title":"Eur J Paediatr Neurol"},{"issue":"9","key":"10.1016\/j.seizure.2026.06.010_bib0011","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1111\/epi.14520","article-title":"Perampanel in routine clinical use across Europe: pooled, multicenter, observational data","volume":"59","author":"Rohracher","year":"2018","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.seizure.2026.06.010_bib0012","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/epi.12527","article-title":"Perampanel for adjunctive treatment of partial-onset seizures: a pooled dose-response analysis of phase III studies","volume":"55","author":"Kramer","year":"2014","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.seizure.2026.06.010_bib0013","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.clinph.2020.11.003","article-title":"Automated quantification of spike-wave activity may be used to predict the development of electrical status epilepticus in sleep (ESES) in children with perinatal stroke","volume":"132","author":"Azeem","year":"2021","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"10.1016\/j.seizure.2026.06.010_bib0014","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1684\/epd.2017.0935","article-title":"The role of EEG in the diagnosis and classification of the epilepsy syndromes: a tool for clinical practice by the ILAE neurophysiology task force (part 1)","volume":"19","author":"Koutroumanidis","year":"2017","journal-title":"Epileptic Disord"},{"issue":"4","key":"10.1016\/j.seizure.2026.06.010_bib0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1684\/epd.2017.0952","article-title":"The role of EEG in the diagnosis and classification of the epilepsy syndromes: a tool for clinical practice by the ILAE neurophysiology task force (part 2)","volume":"19","author":"Koutroumanidis","year":"2017","journal-title":"Epileptic Disord"},{"issue":"10","key":"10.1016\/j.seizure.2026.06.010_bib0016","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/epi.13125","article-title":"Cognition and brain development in children with benign epilepsy with centrotemporal spikes","volume":"56","author":"Garcia-Ramos","year":"2015","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.seizure.2026.06.010_bib0017","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.clinph.2019.03.026","article-title":"Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy","volume":"130","author":"Rehulka","year":"2019","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0018","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/epi4.12849","article-title":"Long-term efficacy and safety of adjunctive perampanel in patients from the Asia-pacific region with refractory focal-onset seizures in study 335 open-label extension","volume":"9","author":"Nishida","year":"2024","journal-title":"Epilepsia Open"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0019","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1212\/CPJ.0000000000000874","article-title":"Psychiatric comorbidities in people with epilepsy","volume":"11","author":"Mula","year":"2021","journal-title":"Neurol Clin Pract"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2015.243","article-title":"Management of psychiatric and neurological comorbidities in epilepsy","volume":"12","author":"Kanner","year":"2016","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0022","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.WNP.0000158699.78529.AF","article-title":"Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns","volume":"22","author":"Chong","year":"2005","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.seizure.2026.06.010_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.107939","article-title":"Behavioral adverse events with brivaracetam, levetiracetam, perampanel, and topiramate: a systematic review","volume":"118","author":"Steinhoff","year":"2021","journal-title":"Epilepsy Behav"},{"issue":"3","key":"10.1016\/j.seizure.2026.06.010_bib0024","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat Rev Neurosci"},{"issue":"1 Pt 2","key":"10.1016\/j.seizure.2026.06.010_bib0025","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1006\/nimg.2001.0839","article-title":"On the functional neuroanatomy of intrinsic and phasic alertness","volume":"14","author":"Sturm","year":"2001","journal-title":"Neuroimage"},{"issue":"9","key":"10.1016\/j.seizure.2026.06.010_bib0026","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S1474-4422(12)70188-6","article-title":"Impaired consciousness in epilepsy","volume":"11","author":"Blumenfeld","year":"2012","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0027","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The epidemiology of epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"issue":"Suppl 1","key":"10.1016\/j.seizure.2026.06.010_bib0028","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/epi.14456","article-title":"Perampanel: does it have broad-spectrum potential?","volume":"60","author":"Potschka","year":"2019","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.seizure.2026.06.010_bib0029","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1212\/WNL.0b013e3182635735","article-title":"Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304","volume":"79","author":"French","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.seizure.2026.06.010_bib0030","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.seizure.2023.01.013","article-title":"The safety of perampanel in different disorders and doses: a meta-analysis","volume":"106","author":"Liu","year":"2023","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.seizure.2026.06.010_bib0031","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phrs.2012.12.006","article-title":"Novel treatment options for epilepsy: focus on perampanel","volume":"70","author":"Franco","year":"2013","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0033","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/epi4.12398","article-title":"Efficacy and safety of perampanel monotherapy in patients with focal-onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period of remission: the open-label study 342 (FREEDOM Study)","volume":"5","author":"Yamamoto","year":"2020","journal-title":"Epilepsia Open"},{"issue":"2","key":"10.1016\/j.seizure.2026.06.010_bib0034","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/ane.12931","article-title":"Retrospective study of perampanel efficacy and tolerability in myoclonic seizures","volume":"138","author":"Gil-Lopez","year":"2018","journal-title":"Acta Neurol Scand"},{"issue":"4","key":"10.1016\/j.seizure.2026.06.010_bib0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/jamaneurol.2025.5625","article-title":"Comparative effectiveness of brivaracetam, cenobamate, lacosamide, and perampanel in focal epilepsy","volume":"83","author":"Cerulli Irelli","year":"2026","journal-title":"JAMA Neurol"},{"issue":"8","key":"10.1016\/j.seizure.2026.06.010_bib0036","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/epi.12212","article-title":"Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pooled analysis of three phase III studies","volume":"54","author":"Steinhoff","year":"2013","journal-title":"Epilepsia"},{"issue":"Pt A","key":"10.1016\/j.seizure.2026.06.010_bib0037","article-title":"Perampanel tolerability in children and adolescents with focal epilepsy: effects on behavior and executive functions","volume":"103","author":"Operto","year":"2020","journal-title":"Epilepsy Behav"},{"issue":"7","key":"10.1016\/j.seizure.2026.06.010_bib0038","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/epi.13417","article-title":"Adjunctive perampanel in adolescents with inadequately controlled partial-onset seizures: a randomized study evaluating behavior, efficacy, and safety","volume":"57","author":"Lagae","year":"2016","journal-title":"Epilepsia"},{"issue":"18","key":"10.1016\/j.seizure.2026.06.010_bib0039","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1212\/WNL.0b013e318254473a","article-title":"Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures","volume":"78","author":"Krauss","year":"2012","journal-title":"Neurology"}],"container-title":["Seizure: European Journal of Epilepsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131126001822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131126001822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:28:44Z","timestamp":1789914524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131126001822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S1059131126001822"],"URL":"https:\/\/doi.org\/10.1016\/j.seizure.2026.06.010","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy, tolerability, and EEG lateralization-based predictors of neuropsychiatric adverse events in pediatric SeLECTS treated with perampanel monotherapy","name":"articletitle","label":"Article Title"},{"value":"Seizure: European Journal of Epilepsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.seizure.2026.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of British Epilepsy Association.","name":"copyright","label":"Copyright"}]}}