{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:12:44Z","timestamp":1791900764054,"version":"4.3.4"},"reference-count":156,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.semarthrit.2005.01.013","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T07:30:18Z","timestamp":1123572618000},"page":"1-10","source":"Crossref","is-referenced-by-count":296,"special_numbering":"S1","title":["Osteoarthritis: An Overview of the Disease and Its Treatment Strategies"],"prefix":"10.1016","volume":"35","author":[{"given":"Piercarlo","family":"Sarzi-Puttini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Cimmino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Caporali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Parazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Zaninelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Atzeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Canesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2005.01.013_bib1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of OA. Classification of Osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.7326\/0003-4819-133-8-200010170-00016","article-title":"Osteoarthritis: new insights","volume":"133","author":"Felson","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7326\/0003-4819-133-9-200011070-00015","article-title":"Osteoarthritis: new insights","volume":"133","author":"Felson","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib4","unstructured":"Maurer K. Basic data on arthritis: knee, hip and sacroiliac joints in adult aged 25-74 years. United States, 1971-1975. Hyattsville, MD, National Centers for Health Statistics, 1979, Vital and Health Statistics, No. 213."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib5","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/art.1780401006","article-title":"Investigation of the association of the CTRM and CTRL-1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study","volume":"40","author":"Meulenbelt","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"suppl A","key":"10.1016\/j.semarthrit.2005.01.013_bib6","article-title":"Prevalence of symptomatic hand osteoarthritis in community-dwelling older persons: the ICARe Dicomano study","volume":"8","author":"Mannoni","year":"2000","journal-title":"Osteoarthritis Cart"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib7","first-page":"35","article-title":"Prevalence of self-reported peripheral joint pain and swelling in an Italian population: the Chiavari study","volume":"19","author":"Cimmino","year":"2001","journal-title":"Clin Exp Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/bmj.1.4751.181","article-title":"Generalised osteoarthritis and Heberden's nodes","volume":"1","author":"Kellgren","year":"1952","journal-title":"BMJ"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib9","unstructured":"Sharma L. Epidemiology of Osteoarthritis. In: Moskowitz RW, Howell DS, Altman RD, et al, eds. Osteoarthritis. Diagnosis and Medical\/Surgical Management, 3rd ed. Philadelphia, London, New York, St. Louis, Sydney, Toronto, WB Saunders Company, 2001;3-27."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF03327357","article-title":"The pathophysiology of osteoarthritis","volume":"15","author":"Iannone","year":"2003","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0009-9120(92)90250-V","article-title":"Cartilage matrix metabolism in osteoarthritis: markers in synovial fluid, serum and urine","volume":"25","author":"Lohmander","year":"1992","journal-title":"Clin Biochem"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/ard.52.8.557","article-title":"Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy","volume":"52","author":"Dieppe","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jor.1100140502","article-title":"Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage","volume":"14","author":"Poole","year":"1996","journal-title":"J Orthop Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib14","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/1529-0131(199707)40:7<1282::AID-ART13>3.0.CO;2-E","article-title":"Alteration of cartilage metabolism by cells from osteoarthritic bone","volume":"40","author":"Westacott","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib15","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI119526","article-title":"Aggrecan degradation in human cartilage: evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints","volume":"100","author":"Lark","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib17","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1172\/JCI116113","article-title":"Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis: evidence for molecular heterogeneity and extensive molecular changes in disease","volume":"90","author":"Rizkalla","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib18","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/art.1780380514","article-title":"Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilages","volume":"38","author":"Cs-Szab\u00f3","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib19","series-title":"Arthritis and Allied Conditions. A Textbook of Rheumatology","article-title":"Cartilage in health and disease","author":"Poole","year":"1997"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib20","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/art.1780400606","article-title":"Enhancement of cartilage matrix protein synthesis in arthritic cartilage","volume":"40","author":"Okimura","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/ar630","article-title":"Aggrecanases and cartilage matrix degradation","volume":"5","author":"Nagase","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/ard.54.4.281","article-title":"Cathepsin B in osteoarthritis: zonal variation of enzyme activity in human femoral head cartilage","volume":"54","author":"Baici","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/art.10185","article-title":"Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis","volume":"46","author":"Konttinen","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2174\/0929867013373417","article-title":"The design, structure, and therapeutic application of matrix metalloproteinase inhibitors","volume":"8","author":"Skiles","year":"2001","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/ar148","article-title":"Articular cartilage and changes in arthritis","volume":"3","author":"Sandell","year":"2001","journal-title":"Arthritis Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib26","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s11926-000-0019-5","article-title":"COX-2, NO, and cartilage damage and repair","volume":"2","author":"Amin","year":"2000","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib27","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/berh.2001.0196","article-title":"The role of nitric oxide in tissue destruction","volume":"15","author":"Abramson","year":"2001","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib28","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib29","first-page":"1662","article-title":"Synovial inflammation in patients with early osteoarthritis of the knee","volume":"17","author":"Myers","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/ar623","article-title":"Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action","volume":"5","author":"Moreland","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1053\/joca.2002.0819","article-title":"Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis","volume":"10","author":"Vilim","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/rheumatology\/36.1.140","article-title":"Elevated serum c-reactive protein levels in osteoarthritis","volume":"36","author":"Sharif","year":"1997","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/ard.50.1.8","article-title":"Study of 500 patients with limb joint osteoarthritis","volume":"50","author":"Cushnaghan","year":"1991","journal-title":"Ann Rheum Dis"},{"issue":"suppl 2","key":"10.1016\/j.semarthrit.2005.01.013_bib34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0049-0172(89)90021-8","article-title":"Pain, synovitis and articular cartilage changes in osteoarthritis","volume":"18","author":"Brandt","year":"1989","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib35","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/art.1780300811","article-title":"The prevalence of knee osteoarthritis in the elderly","volume":"30","author":"Felson","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib36","first-page":"378","article-title":"Longitudinal radiologic evaluation of osteoarthritis of the knee","volume":"19","author":"Dougados","year":"1992","journal-title":"J Rheumatol"},{"issue":"suppl","key":"10.1016\/j.semarthrit.2005.01.013_bib37","first-page":"S236","article-title":"Hip osteoarthritis is not rare in African-Americans and is different than in Caucasians [Abstract]","volume":"40","author":"Jordan","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib38","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/art.1790090610","article-title":"Ethnic differences in self-reported functional status in the rural South: the Johnston County Osteoarthritis Project","volume":"9","author":"Jordan","year":"1996","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib39","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/bmj.312.7036.940","article-title":"Genetic influences on osteoarthritis in women: a twin study","volume":"312","author":"Spector","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib40","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO;2-R","article-title":"Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project","volume":"42","author":"Clark","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/ard.55.5.317","article-title":"Association of two loci on chromosome 2q with nodal osteoarthritis","volume":"55","author":"Wright","year":"1996","journal-title":"Ann Rheum Dis."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1086\/302465","article-title":"Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage","volume":"65","author":"Chapman","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib43","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/1529-0131(199810)41:10<1867::AID-ART20>3.0.CO;2-W","article-title":"Estrogen replacement and worsening of radiographic knee osteoarthritis: the Framingham Study","volume":"41","author":"Zhang","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib44","doi-asserted-by":"crossref","first-page":"353","DOI":"10.7326\/0003-4819-125-5-199609010-00001","article-title":"Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study","volume":"125","author":"McAlindon","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib45","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/1529-0131(199905)42:5<854::AID-ANR3>3.0.CO;2-I","article-title":"Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study","volume":"42","author":"Lane","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib46","first-page":"251","article-title":"Plasma glucose concentrations in symptomatic osteoarthritis: a clinical and epidemiological survey","volume":"8","author":"Cimmino","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/030097401300162969","article-title":"Non-insulin dependent diabetes mellitus (NIDDM) and patterns of osteoarthritis","volume":"30","author":"St\u00fcrmer","year":"2001","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib48","first-page":"1827","article-title":"Serum cholesterol and osteoarthritis","volume":"25","author":"St\u00fcrmer","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib49","first-page":"1032","article-title":"Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study","volume":"27","author":"Zhang","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib50","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/rheumatology\/41.10.1155","article-title":"Influence of obesity on the development of osteoarthritis of the hip: a systematic review","volume":"41","author":"Lievense","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib51","doi-asserted-by":"crossref","first-page":"535","DOI":"10.7326\/0003-4819-116-7-535","article-title":"Weight loss reduces the risk for symptomatic knee osteoarthritis in women","volume":"116","author":"Felson","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib52","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/sj.ijo.0801585","article-title":"Knee Osteoarthritis and obesity","volume":"25","author":"Coggon","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0002-9343(02)01447-X","article-title":"Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors","volume":"114","author":"Karlson","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib54","first-page":"1587","article-title":"Occupational physical demands, knee bending, and knee osteoarthritis: results from the Framingham Study","volume":"18","author":"Felson","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib55","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/art.11012","article-title":"Influence of sporting activities on the development of osteoarthritis of the hip: a systematic review","volume":"49","author":"Lievense","year":"2003","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib56","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1063-4584(97)80001-5","article-title":"Sport practice and osteoarthritis of the limbs","volume":"5","author":"Lequesne","year":"1997","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib57","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9","article-title":"Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women?","volume":"41","author":"Slemenda","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0895-4356(94)90178-3","article-title":"Long-term physical functioning in persons with knee osteoarthritis from NHANES","volume":"47","author":"Ettinger","year":"1994","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib59","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/ard.52.4.258","article-title":"Determinants of disability in osteoarthritis of the knee","volume":"52","author":"McAlindon","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib60","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2105\/AJPH.84.3.351","article-title":"The effects of specific medical conditions on the functional limitations of elders in the Framingham Study","volume":"84","author":"Guccione","year":"1994","journal-title":"Am J Public Health"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib61","first-page":"1581","article-title":"Analysis of disability in knee osteoarthritis","volume":"18","author":"Salaffi","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib62","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1056\/NEJM199804093381506","article-title":"Aging, health risks, and cumulative disability","volume":"338","author":"Vita","year":"1998","journal-title":"N Engl J Med."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib63","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00002281-200209000-00017","article-title":"Impact of osteoarthritis on individuals and society: how much disability?","volume":"14","author":"Brooks","year":"2002","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib64","series-title":"Osteoarthritis","first-page":"23","article-title":"The economics of osteoarthritis","author":"Yelin","year":"1998"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib65","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.1780331101","article-title":"The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand","volume":"33","author":"Altman","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib66","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/art.1780340502","article-title":"The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip","volume":"34","author":"Altman","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib67","first-page":"42","article-title":"The classification of osteoarthritis","volume":"43","author":"Altman","year":"1995","journal-title":"J Rheumatol Suppl"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11926-999-0027-z","article-title":"Clinical assessment and significance of inflammation in knee osteoarthritis","volume":"1","author":"Baddour","year":"1999","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib69","first-page":"2263","article-title":"Erythrocyte sedimentation rate within rheumatic disease clinics","volume":"24","author":"Giacomello","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0049-0172(95)80020-4","article-title":"Acute-phase proteins in osteoarthritis","volume":"25","author":"Sipe","year":"1995","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib71","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/art.1780281209","article-title":"Quantitation of keratan sulfate in blood as marker of cartilage metabolism","volume":"28","author":"Thonar","year":"1985","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib72","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/art.1780380608","article-title":"Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee","volume":"38","author":"Sharif","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib73","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/art.1780340704","article-title":"Elevated plasma levels of hyaluronate in patients with osteoarthritis and rheumatoid arthritis","volume":"34","author":"Goldberg","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib74","first-page":"964","article-title":"Urinary hydroxypyridinium cross-links provide indices of cartilage and bone involvement in arthritic disease","volume":"16","author":"Seibel","year":"1989","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib75","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/rheumatology\/28.5.393","article-title":"Serum and synovial fluid osteocalcin (bone GLA protein) levels in joint disease","volume":"28","author":"Campion","year":"1989","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib76","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/rheumatology\/keg102","article-title":"Hydroxypyridinium collagen crosslinks in serum, urine, synovial fluid and synovial tissue in patients with rheumatoid arthritis compared with osteoarthritis","volume":"42","author":"Kaufmann","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib77","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/art.10822","article-title":"Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project","volume":"48","author":"Jordan","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib78","first-page":"1043","article-title":"Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis","volume":"30","author":"Bruyere","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib79","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1056\/NEJM199107113250203","article-title":"Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee","volume":"325","author":"Bradley","year":"1991","journal-title":"N Engl J Med."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib80","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/art.1780360904","article-title":"Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee","volume":"36","author":"Williams","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib81","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/jama.279.9.657","article-title":"Acetaminophen and other risk factors for excessive warfarin anticoagulation","volume":"279","author":"Hylek","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib82","first-page":"1358","article-title":"Efficacy and safety of tramadol HCl in breakthrough musculoskeletal pain attributed to osteoarthritis","volume":"25","author":"Roth","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib83","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1053\/berh.2001.0175","article-title":"Pharmacological therapy of osteoarthritis","volume":"15","author":"Hochberg","year":"2001","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.1780370102","article-title":"Are there differences among nonsteroidal anti-inflammatory drugs?","volume":"37","author":"Furst","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib85","doi-asserted-by":"crossref","first-page":"787","DOI":"10.7326\/0003-4819-115-10-787","article-title":"Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs","volume":"115","author":"Gabriel","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib86","doi-asserted-by":"crossref","first-page":"359","DOI":"10.7326\/0003-4819-109-5-359","article-title":"Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons","volume":"109","author":"Griffin","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib87","first-page":"204","article-title":"Risk factors for serious nonsteroidal-induced gastrointestinal complications: regression analysis of the MUCOSA Trial","volume":"28","author":"Simon","year":"1996","journal-title":"Family Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib88","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(98)12154-2","article-title":"COX-2 inhibitors","volume":"353","author":"Hawkey","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib89","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1053\/bean.2002.0262","article-title":"Pharmacology of systemic analgesics","volume":"16","author":"Camu","year":"2002","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib90","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1056\/NEJM200011233432103","article-title":"VIGOR Study Group","volume":"343","author":"Bombardier","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib91","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jama.284.10.1247","article-title":"Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial","volume":"284","author":"Silverstein","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib92","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/bmj.325.7365.624","article-title":"Observational study of upper gastrointestinal hemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs","volume":"325","author":"Mamdani","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0149-2918(03)90003-8","article-title":"The impact of nonsteroidal anti-inflammatory drugs on blood pressure, with an emphasis on newer agents","volume":"25","author":"Armstrong","year":"2003","journal-title":"Clin Ther"},{"issue":"suppl 1","key":"10.1016\/j.semarthrit.2005.01.013_bib94","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/sarh.2002.37216","article-title":"Anti-inflammatory agents and renal function","volume":"32","author":"Brater","year":"2002","journal-title":"Semin Arthritis Rheum"},{"issue":"suppl 15","key":"10.1016\/j.semarthrit.2005.01.013_bib95","article-title":"Cardiorenal differences among NSAIDs and coxibs: real-world experience","volume":"8","author":"Sonnenblick","year":"2002","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib96","article-title":"Comparative safety of traditional non-steroidal anti-inflammatory drugs and COX-2 selective inhibitors","volume":"31","author":"Bannwarth","year":"2002","journal-title":"Presse Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib97","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.1068711","article-title":"Role of prostacyclin in the cardiovascular response to thromboxane A2","volume":"296","author":"Cheng","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib98","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/01.EDE.0000034633.74133.C3","article-title":"Nonsteroidal antiinflammatory drugs as a trigger of clinical heart failure","volume":"14","author":"Garcia Rodriguez","year":"2003","journal-title":"Epidemiology"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib99","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0140-6736(02)11131-7","article-title":"COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease","volume":"360","author":"Ray","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib100","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0885-3924(02)00383-4","article-title":"Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial","volume":"23","author":"Caldwell","year":"2002","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib101","first-page":"383","article-title":"Treatment of arthritis with topical capsaicin: a double-blind trial","volume":"13","author":"Deal","year":"1991","journal-title":"Clin Ther"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib102","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/1529-0131(199904)42:3<475::AID-ANR12>3.0.CO;2-S","article-title":"Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: results of a multicenter, randomized, controlled trial","volume":"42","author":"Ravaud","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib103","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/ar623","article-title":"Intra-articular hyaluronan (hyaluronic acid) and hyalans for the treatment of osteoarthritis: mechanism of action","volume":"5","author":"Moreland","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib104","first-page":"2203","article-title":"Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial","volume":"25","author":"Altman","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib105","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1053\/joca.2000.0398","article-title":"Morphological analysis of articular cartilage biopsies from a randomized clinical study comparing the effects of 500-730 kDa sodium hyaluronate (Hyalgan) and methylprednisolone acetate on primary osteoarthritis of the knee","volume":"9","author":"Guidolin","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib106","first-page":"375","article-title":"Intra-articular treatment of knee osteoarthritis","volume":"9","author":"Leardini","year":"1991","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib107","first-page":"53","article-title":"Effet du traitement par le sulfate de galactosaminoglucuronoglycane sur l'estase granulocytaire synovial de patients atteints d'osteoarthrose","volume":"14","author":"De Gennaro","year":"1992","journal-title":"Liter Rhumatologica"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib108","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s11926-001-0065-7","article-title":"Joint structure modification in osteoarthritis: development of SMOAD drugs","volume":"3","author":"Beary","year":"2001","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib109","doi-asserted-by":"crossref","first-page":"14014","DOI":"10.1073\/pnas.93.24.14014","article-title":"A novel mechanism of action of tetracyclines: effects on nitric oxide synthases","volume":"93","author":"Amin","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib110","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/art.10768","article-title":"Immunologic intervention in the pathogenesis of osteoarthritis","volume":"48","author":"Yuan","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib111","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/art.10842","article-title":"Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach","volume":"48","author":"Kafienah","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib112","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jama.283.11.1469","article-title":"Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis","volume":"283","author":"McAlindon","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib113","doi-asserted-by":"crossref","first-page":"26","DOI":"10.12968\/pnur.1999.10.19.26","article-title":"Glucosamine for osteoarthritis","volume":"10","author":"Blake","year":"2002","journal-title":"Adv Nurse Pract"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib114","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(00)03610-2","article-title":"Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial","volume":"357","author":"Reginster","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib115","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1002\/1529-0131(200111)44:11<2539::AID-ART434>3.0.CO;2-T","article-title":"Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial","volume":"44","author":"Dougados","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib116","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jama.283.11.1469","article-title":"Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis","volume":"283","author":"McAlindon","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib117","unstructured":"Hicks JE, Perry MB, Gerber LH. Rehabilitation in the management of patients with osteoarthritis. In: Moskowitz RW, Howell DS, Altman RD, et al, eds. Osteoarthritis: Diagnosis and Medical\/Surgical Management, 3rd ed. Philadelphia, London, New York, St. Louis, Sydney, Toronto, WB Saunders Company, 2001;413-6."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib118","doi-asserted-by":"crossref","first-page":"133","DOI":"10.7326\/0003-4819-121-2-199407150-00010","article-title":"Published trials of nonmedicinal and noninvasive therapies for hip and knee osteoarthritis","volume":"121","author":"Puett","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib119","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00002281-200303000-00010","article-title":"Effectiveness and safety of strengthening, aerobic, and coordination exercises for patients with osteoarthritis","volume":"15","author":"Bischoff","year":"2003","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib120","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/1529-0131(199907)42:7<1361::AID-ANR9>3.0.CO;2-9","article-title":"Effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review of randomized clinical trials","volume":"42","author":"van Baar","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib121","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00003086-200303000-00025","article-title":"Exercise improves early functional recovery after total hip arthroplasty","volume":"408","author":"Gilbey","year":"2003","journal-title":"Clin Orthop"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib122","first-page":"47","article-title":"Bracing and heel wedging for unicompartmental osteoarthritis of the knee","volume":"11","author":"Pollo","year":"1998","journal-title":"Am J Knee Surg"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib123","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00003086-198708000-00021","article-title":"Clinical evaluation of the treatment of osteoarthritic knees using a newly designed wedged insole","volume":"221","author":"Sasaki","year":"1987","journal-title":"Clin Orthop"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib124","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/anr.1780321108","article-title":"Efficacy of physical conditioning exercise in patients with rheumatoid arthritis or osteoarthritis","volume":"32","author":"Minor","year":"1989","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib125","doi-asserted-by":"crossref","unstructured":"Brosseau L, Casimiro L, Robinson V, Milne S, Shea B, Judd M, et al. Therapeutic ultrasound for treating patellofemoral pain syndrome. Cochrane Database Syst Rev 2001;CD003375.","DOI":"10.1002\/14651858.CD003375"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib126","doi-asserted-by":"crossref","unstructured":"Hulme J, Robinson V, DeBie R, Wells G, Judd M, Tugwell P. Electromagnetic fields for the treatment of osteoarthritis. Cochrane Database Syst Rev 2002; CD003523.","DOI":"10.1002\/14651858.CD003523"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib127","unstructured":"Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Knipschild PG. Balneotherapy for rheumatoid arthritis and osteoarthritis. Cochrane Database Syst Rev 2000; CD000518."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib128","first-page":"177","article-title":"Cryotherapy in rehabilitative medicine","volume":"30","author":"Cazzola","year":"1994","journal-title":"Eur Med Phys"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib129","first-page":"1042","article-title":"Managing musculoskeletal complaints with rehabilitation therapy: summary of the Philadelphia Panel evidence-based clinical practice guidelines on musculoskeletal rehabilitation interventions","volume":"51","author":"Harris","year":"2002","journal-title":"J Family Pract"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib130","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/1529-0131(199608)9:4<292::AID-ANR1790090414>3.0.CO;2-4","article-title":"Patient education interventions in osteoarthritis and rheumatoid arthritis: a meta-analytic comparison with nonsteroidal antiinflammatory drug treatment","volume":"9","author":"Superio-Cabuslay","year":"1996","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib131","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/anr.1780321212","article-title":"Can the provision of information to patients with osteoarthritis improve functional status?","volume":"32","author":"Weinberger","year":"1989","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib132","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/art.1780360403","article-title":"Evidence suggesting that health education for self-management in patients with chronic arthritis has sustained health benefits while reducing health care costs","volume":"36","author":"Lorig","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib133","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/art.1780280612","article-title":"Outcomes of self-help education for patients with arthritis","volume":"28","author":"Lorig","year":"1985","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib134","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/1529-0131(199608)9:4<279::AID-ANR1790090413>3.0.CO;2-6","article-title":"Spouse-assisted coping skills training in the management of osteoarthritic knee pain","volume":"9","author":"Keefe","year":"1996","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib135","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/art.1780390818","article-title":"Health outcomes of two telephone interventions for patients with rheumatoid arthritis or osteoarthritis","volume":"39","author":"Maisiak","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib136","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/art.1790100205","article-title":"The effects of social support and education interventions on health care costs","volume":"10","author":"Cronan","year":"1997","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib137","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1001\/jama.280.18.1569","article-title":"Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey","volume":"280","author":"Eisenberg","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib138","doi-asserted-by":"crossref","first-page":"409","DOI":"10.7326\/0003-4819-131-6-199909210-00003","article-title":"Use of complementary therapies for arthritis among patients of rheumatologists","volume":"131","author":"Rao","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib139","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1001\/jama.279.19.1548","article-title":"Why patients use alternative medicine: results of a national study","volume":"279","author":"Astin","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib140","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3109\/03009749709065717","article-title":"Acupuncture as a symptomatic treatment of osteoarthritis","volume":"26","author":"Ernst","year":"1997","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib141","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/1529-0131(200104)44:4<819::AID-ANR138>3.0.CO;2-P","article-title":"Acupuncture for osteoarthritis of the knee: a systematic review","volume":"44","author":"Ezzo","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib142","first-page":"209","article-title":"Osteotomies about the hip for the prevention and treatment of osteoarthritis","volume":"45","author":"Millis","year":"1996","journal-title":"Instr Course Lect"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib143","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00003086-199712000-00012","article-title":"Survivorship of cemented total knee arthroplasty","volume":"345","author":"Font-Rodriguez","year":"1997","journal-title":"Clin Orthop"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib144","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1001\/jama.273.24.1950","article-title":"Total hip replacement. NIH Consensus Development Panel on Total Hip Replacement","volume":"273","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib145","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0883-5403(94)90093-0","article-title":"Costs of elective total hip arthroplasty during the first year","volume":"9","author":"Laupacis","year":"1994","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib146","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00003086-199712000-00018","article-title":"Cost effectiveness and quality of life in knee arthroplasty","volume":"345","author":"Lavernia","year":"1997","journal-title":"Clin Orthop"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib147","series-title":"Rheumatology","first-page":"1853","article-title":"Management of limb joint osteoarthritis","author":"Lozada","year":"2003"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib148","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jama.275.11.858","article-title":"A cost-effectiveness analysis of total hip arthroplasty for osteoarthritis of the hip","volume":"275","author":"Chang","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib149","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2106\/00004623-199901000-00016","article-title":"Wear in total hip and knee replacements","volume":"81","author":"Schmalzried","year":"1999","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib150","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/art.1780381104","article-title":"Guidelines for the medical management of osteoarthritis","volume":"38","author":"Hochberg","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib151","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/art.1780381103","article-title":"Guidelines for the medical management of osteoarthritis","volume":"38","author":"Hochberg","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib152","doi-asserted-by":"crossref","unstructured":"Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum 2000;43:1905-15.","DOI":"10.1002\/1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib153","unstructured":"American Pain Society. Guidelines for the management of pain in osteoarthritis, rheumatoid arthritis and juvenile chronic arthritis. Glenview, March 2002."},{"key":"10.1016\/j.semarthrit.2005.01.013_bib154","first-page":"6","article-title":"The role of Coxibs in the treatment of osteoarthritis","volume":"55","author":"Canesi","year":"2003","journal-title":"Consensus Conference. Reumatismo Suppl"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib155","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/rheumatology\/40.8.841","article-title":"From protocols to principles, from guidelines to toolboxes: aids to good management of osteoarthritis","volume":"40","author":"Dieppe","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2005.01.013_bib156","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.semarthrit.2005.01.014","article-title":"The characteristics of symptomatic osteoarthritis in general and specialist practice in Italy: design and methods of the AMICA study","volume":"35","author":"Parazzini","year":"2005","journal-title":"Semin Arthritis Rheum"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017205000338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017205000338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T13:58:25Z","timestamp":1706450305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017205000338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":156,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0049017205000338"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2005.01.013","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}