{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:08:01Z","timestamp":1792598881340,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.semarthrit.2006.11.004","type":"journal-article","created":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T07:56:16Z","timestamp":1170748576000},"page":"380-385","source":"Crossref","is-referenced-by-count":59,"title":["Exploring the Cause of the Most Ancient Clinical Sign of Medicine: Finger Clubbing"],"prefix":"10.1016","volume":"36","author":[{"given":"Manuel","family":"Martinez-Lavin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2006.11.004_bib1","series-title":"Medicine: An Illustrated History","first-page":"216","author":"Lyons","year":"1978"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib2","first-page":"193","article-title":"Uber knochenver\u00e4nderugen bei chronishen lungen und herzkrankheiten","volume":"18","author":"Bamberger","year":"1891","journal-title":"Z Klin Med"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib3","first-page":"1","article-title":"De l\u2019ost\u00e9o-arthropathie hypertrophiante pneumique","volume":"10","author":"Marie","year":"1890","journal-title":"Rev Med"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib4","series-title":"Rheumatology","article-title":"Hypertrophic osteoarthropathy","author":"Martinez-Lavin","year":"2007"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib5","first-page":"151","article-title":"Hypertrophic osteoarthropathy in congenital cyanotic cardiopathy, description of 2 cases","volume":"50","author":"Pineda","year":"1980","journal-title":"Arch Inst Cardiol Mex"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib6","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/art.1780251007","article-title":"Hypertrophic osteoarthropathy in cyanotic congenital heart disease: its prevalence and relationship to bypass of the lung","volume":"25","author":"Mart\u00ednez-Lav\u00edn","year":"1982","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(56)91186-2","article-title":"Reversal of pulmonary hypertrophic osteoarthropathy by vagotomy","volume":"1","author":"Flavell","year":"1956","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.7326\/0003-4819-81-4-555","article-title":"Loss of symptoms of pulmonary hypertrophic osteoarthropathy after laparotomy","volume":"81","author":"Greco","year":"1974","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib9","first-page":"6","article-title":"Digital clubbing and hypertrophic ostearthropathy: a unifying hypothesis","volume":"14","author":"Mart\u00ednez-Lav\u00edn","year":"1987","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib10","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/S0140-6736(87)91132-9","article-title":"Megakaryocytes and platelet clumps as the cause of finger clubbing","volume":"ii","author":"Dickinson","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib11","first-page":"59","article-title":"Macrothrombocytes in the peripheral circulation of patients with cardiogenic hypertrophic osteoarthropathy","volume":"9","author":"Vazquez-Abad","year":"1991","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0002-9440(10)64518-X","article-title":"Platelet production in the pulmonary capillary bed: new ultrastructural evidence for an old concept","volume":"157","author":"Zucker-Franklin","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib13","first-page":"765","article-title":"von Willebrand factor antigen in hypertrophic osteoarthropathy","volume":"19","author":"Matucci-Cerinic","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0049-0172(85)90045-9","article-title":"The skeletal manifestations of clubbing: a study in patients with cyanotic heart disease and hypertrophic osteoarthropathy","volume":"14","author":"Pineda","year":"1985","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2214\/ajr.148.4.773","article-title":"Periostitis in hypertrophic osteoarthropathy","volume":"148","author":"Pineda","year":"1987","journal-title":"AJR Am J Roentgenol"},{"issue":"Suppl. 7","key":"10.1016\/j.semarthrit.2006.11.004_bib16","first-page":"73","article-title":"Circulating plasma levels of platelet-derived growth factor in patients with hypertrophic osteoarthropathy","volume":"10","author":"Fonseca","year":"1992","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib17","first-page":"2267","article-title":"Features of hypertrophic osteoarthropathy in patients with POEMS syndrome: a metaanalysis","volume":"24","author":"Mart\u00ednez-Lav\u00edn","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(96)91261-1","article-title":"Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome","volume":"347","author":"Watanabe","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib19","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/art.1780400430","article-title":"Growth factors in POEMS syndrome: evidence for a marked increase in circulating vascular endothelial growth factor","volume":"40","author":"Soubrier","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2003-0027","article-title":"Vascular endothelial growth factor: basic science and clinical progress","volume":"25","author":"Ferrara","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib22","first-page":"57","article-title":"Vascular endothelial growth factor and hypertrophic osteoarthropathy","volume":"18","author":"Silveira","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib23","first-page":"614","article-title":"Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy","volume":"31","author":"Olan","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib24","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/path.1565","article-title":"Vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF) play a central role in the pathogenesis of digital clubbing","volume":"203","author":"Atkinson","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib25","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1164\/ajrccm\/140.4.1063","article-title":"A study of capillary morphology in the digits of patients with acquired clubbing","volume":"140","author":"Fara","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0007-0971(88)90092-7","article-title":"The pathology of clubbing: vascular changes in the nail bed","volume":"82","author":"Currie","year":"1988","journal-title":"Br J Dis Chest"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/art.1780190317","article-title":"Articular manifestations of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma","volume":"19","author":"Schumacher","year":"1976","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/ard.47.3.218","article-title":"The arthropathy of cystic fibrosis","volume":"47","author":"Dixey","year":"1988","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/02724936.1989.11748622","article-title":"Arterial oxygen tension, haemoglobin F and red cell 2, 3 diphosphoglycerate in sickle cell anaemia patients with digital clubbing","volume":"9","author":"Adekile","year":"1989","journal-title":"Ann Trop Paediatr"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ppul.1950100106","article-title":"Digital clubbing and pulmonary function abnormalities in children with lung disease","volume":"10","author":"Paton","year":"1991","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/thx.42.2.117","article-title":"Significance of finger clubbing in asbestosis","volume":"42","author":"Coutts","year":"1987","journal-title":"Thorax"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib32","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1089\/10507250360731541","article-title":"Graves\u2019 dermopathy and acropachy are markers of severe Graves\u2019 ophthalmopathy","volume":"13","author":"Fatourechi","year":"2003","journal-title":"Thyroid"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib33","first-page":"639","article-title":"Relationships among digital clubbing, disease severity, and serum prostaglandins F2alpha and E concentrations in cystic fibrosis patients","volume":"117","author":"Lemen","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0002-9343(94)90305-0","article-title":"Toxic effects of intravenous and oral prostaglandin E therapy in patients with liver disease","volume":"97","author":"Cattral","year":"1994","journal-title":"Am J Med"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib35","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1046\/j.1365-2362.1996.2260560.x","article-title":"Elevated serum transforming growth factor beta 1 level in primary lung cancer patients with finger clubbing","volume":"26","author":"Hirakata","year":"1996","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib36","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1651-2227.2000.tb00407.x","article-title":"Plasma immunoreactive endothelin levels in children with cystic fibrosis","volume":"89","author":"Siahanidou","year":"2000","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib37","first-page":"85","article-title":"The relationship between digital clubbing and serum growth hormone level in patients with lung cancer","volume":"5","author":"Yorgancioglu","year":"1996","journal-title":"Monaldi Arch Chest Dis"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0002-9343(79)90078-0","article-title":"Hypertrophic hepatic osteoarthropathy","volume":"67","author":"Epstein","year":"1979","journal-title":"Am J Med"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0940-2993(11)80506-3","article-title":"Hypertrophic osteopathy in rats following chronic administration of SDZ MNS 949, an isoquinoline","volume":"45","author":"Langle","year":"1994","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00246-002-0266-5","article-title":"Increased angiogenic growth factor in cyanotic congenital heart disease","volume":"24","author":"Himeno","year":"2003","journal-title":"Pediatric Cardiol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/(SICI)1097-0185(19990101)254:1<61::AID-AR8>3.0.CO;2-D","article-title":"Differential immunolocalization of VEGF in rat and human adult lung, and in experimental rat lung fibrosis: light, fluorescence, and electron microscopy","volume":"254","author":"Fehrenbach","year":"1999","journal-title":"Anat Rec"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/hupa.2001.21139","article-title":"Expression of vascular endothelial growth factor (VEGF) and VEGF receptor-1 (Flt-1) in Graves disease possible correlates with increased vascular density","volume":"32","author":"Nagura","year":"2001","journal-title":"Human Pathol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/sj.bjc.6690650","article-title":"VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours","volume":"81","author":"Ohta","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib44","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.3748\/wjg.v9.i12.2832","article-title":"Spider angiomas in patients with liver cirrhosis: role of vascular endothelial growth factor and basic fibroblast growth factor","volume":"9","author":"Li","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib45","first-page":"861","article-title":"Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma","volume":"3","author":"Fontanini","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.semarthrit.2006.11.004_bib46","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1172\/JCI117258","article-title":"Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts","volume":"93","author":"Harada","year":"1994","journal-title":"J Clin Invest"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017206001673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017206001673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T04:03:37Z","timestamp":1556078617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017206001673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0049017206001673"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2006.11.004","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}