{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:45:13Z","timestamp":1787586313834,"version":"build-2736575974"},"reference-count":92,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.semarthrit.2010.12.003","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T04:15:33Z","timestamp":1296792933000},"page":"116-130","source":"Crossref","is-referenced-by-count":119,"title":["Imaging of Synovitis in Osteoarthritis: Current Status and Outlook"],"prefix":"10.1016","volume":"41","author":[{"given":"Daichi","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Katur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Felson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoung-Oh","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris","family":"Alomran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2010.12.003_bib1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/art.27290","article-title":"The Role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis","volume":"62","author":"Bondeson","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03008209909005273","article-title":"The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models","volume":"40","author":"Goldring","year":"1999","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcna.2008.08.009","article-title":"Etiopathogenesis of osteoarthritis","volume":"93","author":"Brandt","year":"2009","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.addr.2006.01.020","article-title":"Osteoarthritis: pathobiology-targets and ways for therapeutic intervention","volume":"58","author":"Aigner","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib6","first-page":"1247","article-title":"Prevalence of cartilage shards in synovium and their association with synovitis in patients with early and end stage osteoarthritis","volume":"19","author":"Myers","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/art.1780310214","article-title":"Articular responses to purified cartilage proteoglycans","volume":"31","author":"Boniface","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00296-009-1032-2","article-title":"Investigation of calcium crystals in OA knees","volume":"30","author":"Fuerst","year":"2010","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib9","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1002\/art.21373","article-title":"Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity","volume":"52","author":"Loeuille","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.berh.2009.08.011","article-title":"Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?","volume":"24","author":"Attur","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00296-008-0518-7","article-title":"Early lymphocyte activation in the synovial microenvironment in patients with osteoarthritis: comparison with rheumatoid arthritis patients and healthy controls","volume":"28","author":"Rollin","year":"2008","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib12","first-page":"1330","article-title":"Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis","volume":"28","author":"Hill","year":"2001","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.joca.2005.01.005","article-title":"Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis\u2014results of a 1 year longitudinal arthroscopic study in 422 patients","volume":"13","author":"Ayral","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs","author":"Baker","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib15","first-page":"1662","article-title":"Synovial inflammation in patients with early osteoarthritis of the knee","volume":"17","author":"Myers","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib16","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1136\/ard.2004.025270","article-title":"Synovial tissue inflammation in early and late osteoarthritis","volume":"64","author":"Benito","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.rdc.2008.04.006","article-title":"Imaging in osteoarthritis","volume":"34","author":"Guermazi","year":"2008","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib18","doi-asserted-by":"crossref","DOI":"10.1136\/ard.2009.124875","article-title":"Pain in hand osteoarthritis is associated with inflammation: the value of ultrasound","author":"Kortekaas","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib19","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/art.24312","article-title":"An ultrasonographic study of osteoarthritis of the hand: synovitis and its relationship to structural pathology and symptoms","volume":"59","author":"Keen","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib20","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/rheumatology\/keq010","article-title":"Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study","volume":"49","author":"Keen","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/ard.2008.099564","article-title":"Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study","volume":"69","author":"Conaghan","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.2007.080382","article-title":"Contrast-enhanced ultrasound in monitoring the efficacy of a bradykinin receptor 2 antagonist in painful knee osteoarthritis compared with MRI","volume":"68","author":"Song","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/ard.2006.067462","article-title":"Knee osteoarthritis","volume":"67","author":"Song","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keq030","article-title":"Steroid injection for hip osteoarthritis: efficacy under ultrasound guidance","author":"Micu","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.joca.2003.11.003","article-title":"Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis","volume":"12","author":"Peterfy","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib26","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1136\/ard.2006.067470","article-title":"Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis","volume":"66","author":"Hill","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib27","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.2214\/AJR.08.2038","article-title":"Hoffa's Fat Pad: evaluation on unenhanced mr images as a measure of patellofemoral synovitis in osteoarthritis","volume":"192","author":"Roemer","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00256-004-0828-0","article-title":"MRI assessment of knee osteoarthritis: Knee Osteoarthritis Scoring System (KOSS)\u2014inter-observer and intra-observer reproducibility of a compartment-based scoring system","volume":"34","author":"Kornaat","year":"2005","journal-title":"Skeletal Radiol"},{"issue":"Suppl 1","key":"10.1016\/j.semarthrit.2010.12.003_bib29","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1016\/S1063-4584(09)60423-4","article-title":"Whole-knee synovitis semiquantitatively assessed on T1-weighted contrast-enhanced MRI is associated with radiographic tibiofemoral osteoarthritis and severe meniscal damage: The MOST Study (Abstract)","volume":"17","author":"Guermazi","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib30","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10067-010-1522-3","article-title":"Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery","volume":"29","author":"Liu","year":"2010","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib31","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/rheumatology\/kei094","article-title":"The validation of simple scoring methods for evaluating compartment-specific synovitis detected by MRI in knee osteoarthritis","volume":"44","author":"Rhodes","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib32","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.joca.2009.03.006","article-title":"Magnetic resonance imaging in osteoarthritis: which method best reflects synovial membrane inflammation?","volume":"17","author":"Loeuille","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib33","first-page":"S696","article-title":"Assessment of synovitis in knee osteoarthritis on contrast-enhanced MRI using a novel comprehensive semiquantitative scoring system\u2014The MOST Study (Abstract)","volume":"58","author":"Guermazi","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib34","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.joca.2010.06.006","article-title":"Ultrasound-detected synovitis with power Doppler signal is associated with severe radiographic damage and reduced cartilage thickness in hand osteoarthritis","volume":"18","author":"Mancarella","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib35","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1136\/ard.2005.037994","article-title":"EULAR report on the use of ultrasonography in painful knee osteoarthritis","volume":"64","author":"D'Agostino","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib36","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1148\/radiol.2523082197","article-title":"Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study","volume":"252","author":"Roemer","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib37","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.rcl.2009.04.007","article-title":"Ultrasonography in osteoarthritis","volume":"47","author":"Keen","year":"2009","journal-title":"Radiol Clin North Am"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/rheumatology\/38.3.195","article-title":"The current status of ultrasonography in rheumatology","volume":"38","author":"Wakefield","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib39","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/joca.2001.0433","article-title":"Guidance by ultrasound of intra-articular injections in the knee and hip joints","volume":"9","author":"Qvistgaard","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mcna.2008.08.003","article-title":"Osteoarthritis: current role of imaging","volume":"93","author":"Guermazi","year":"2009","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib41","first-page":"2485","article-title":"Musculoskeletal ultrasound including definitions for ultrasonographic pathology","volume":"32","author":"Wakefield","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/art.1780340205","article-title":"Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis: in vivo effects of antirheumatic drugs","volume":"34","author":"Haraoui","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/art.20054","article-title":"Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: a comparison with arthroscopy and clinical examination","volume":"50","author":"Karim","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib44","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/1529-0131(200102)44:2<331::AID-ANR50>3.0.CO;2-0","article-title":"Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis","volume":"44","author":"Walther","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1148\/radiol.2251011272","article-title":"Synovial tissue of the hip at power Doppler US: correlation between vascularity and power Doppler US signal","volume":"225","author":"Walther","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib46","first-page":"439","article-title":"Colour Doppler ultrasonography to detect pannus in knee joint synovitis","volume":"18","author":"Schmidt","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/028418519503600104","article-title":"Ultrasonography in arthritis of the knee","volume":"36","author":"Ostergaard","year":"1995","journal-title":"Acta Radiol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib48","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/ard.60.7.641","article-title":"Guidelines for musculoskeletal ultrasound in rheumatology","volume":"60","author":"Backhaus","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib49","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/ard.2007.079483","article-title":"Can ultrasonography improve on radiographic assessment in osteoarthritis of the hands?","volume":"67","author":"Keen","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib50","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/02841850600551508","article-title":"Indications of inflammation visualized by ultrasound in osteoarthritis of the knee","volume":"47","author":"Kristoffersen","year":"2006","journal-title":"Acta Radiol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib51","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s00223-009-9302-2","article-title":"Association between ultrasonographic findings and bone\/cartilage biomarkers in patients with early-stage knee osteoarthritis","volume":"85","author":"Kumm","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.semarthrit.2006.04.009","article-title":"Power Doppler ultrasound in musculoskeletal disease: A systematic review","volume":"36","author":"Joshua","year":"2006","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib53","first-page":"839","article-title":"Summary findings of a systematic review of the ultrasound assessment of synovitis","volume":"34","author":"Joshua","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib54","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/ard.2007.077081","article-title":"The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis","volume":"67","author":"Keen","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib55","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-2004-861576","article-title":"Magnetic resonance imaging of the synovium in rheumatoid arthritis","volume":"8","author":"Ostergaard","year":"2004","journal-title":"Semin Musculoskelet Radiol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib56","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/ard.2006.066183","article-title":"The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score)","volume":"67","author":"Hunter","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib57","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0730-725X(94)00119-N","article-title":"Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis","volume":"13","author":"Fernandez-Madrid","year":"1995","journal-title":"Magn Reson Imaging"},{"issue":"Suppl 3","key":"10.1016\/j.semarthrit.2010.12.003_bib58","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.joca.2008.06.007","article-title":"A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI","volume":"16","author":"Pelletier","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib59","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.joca.2008.09.020","article-title":"Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI","volume":"17","author":"Roemer","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib60","article-title":"Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis?","author":"Yusuf","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib61","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1148\/radiol.2373041989","article-title":"Osteoarthritis of the knee: comparison of MR imaging findings with radiographic severity measurements and pain in middle-aged women","volume":"237","author":"Hayes","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib62","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.joca.2006.03.015","article-title":"The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis","volume":"14","author":"Torres","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib63","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.joca.2009.06.006","article-title":"Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative","volume":"17","author":"Lo","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib64","doi-asserted-by":"crossref","first-page":"R172","DOI":"10.1186\/ar3132","article-title":"Longitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain","volume":"12","author":"Hayashi","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib65","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00256-003-0724-z","article-title":"MRI of Hoffa's fat pad","volume":"33","author":"Saddik","year":"2004","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib66","first-page":"1524","article-title":"An outcome measure for Japanese people with knee osteoarthritis","volume":"32","author":"Akai","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib67","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2214\/ajr.179.1.1790193","article-title":"Patterns of gadopentetate-enhanced MR imaging of radiocarpal joints of healthy subjects","volume":"179","author":"Partik","year":"2002","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib68","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/art.20135","article-title":"Magnetic resonance imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis","volume":"50","author":"Ejbjerg","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib69","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/02841859409172382","article-title":"Dynamic gadolinium-enhanced MR imaging in active and inactive immunoinflammatory gonarthritis","volume":"35","author":"Ostergaard","year":"1994","journal-title":"Acta Radiol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib70","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2214\/ajr.142.3.619","article-title":"Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent","volume":"142","author":"Weinmann","year":"1984","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib71","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/art.1780241215","article-title":"Permeability of rheumatoid and normal human synovium to specific plasma proteins","volume":"24","author":"Levick","year":"1981","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib72","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0730-725X(98)00008-3","article-title":"Quantification of synovistis by MRI: correlation between dynamic and static gadolinium-enhanced magnetic resonance imaging and microscopic and macroscopic signs of synovial inflammation","volume":"16","author":"Ostergaard","year":"1998","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib73","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/art.1780370807","article-title":"Dynamic magnetic resonance imaging for the evaluation of synovitis in patients with rheumatoid arthritis","volume":"37","author":"Tamai","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib74","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/art.1780401020","article-title":"Magnetic resonance imaging-determined synovial membrane and joint effusion volumes in rheumatoid arthritis and osteoarthritis: comparison with the macroscopic and microscopic appearance of the synovium","volume":"40","author":"Ostergaard","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib75","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/02841850600838210","article-title":"Contrast-enhanced dynamic magnetic resonance imaging of finger joints in osteoarthritis and rheumatoid arthritis: an analysis based on pharmacokinetic modeling","volume":"47","author":"Kirkhus","year":"2006","journal-title":"Acta Radiol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2010.07.008","article-title":"Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI","author":"Roemer","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib77","first-page":"S72","article-title":"Baseline effusion but not synovitis predicts cartilage loss over 30 months in subjects without tibiofemoral osteoarthritis\u2014Results from the Multicenter Osteoarthritis (MOST) Study (Abstract)","volume":"59","author":"Roemer","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib78","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2215\/CJN.06580909","article-title":"Low risk for nephrogenic systemic fibrosis in nondialysis patients who have chronic kidney disease and are investigated with gadolinium-enhanced magnetic resonance imaging","volume":"5","author":"Chrysochou","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib79","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.3899\/jrheum.090350","article-title":"Reducing invasiveness, duration, and cost of magnetic resonance imaging in rheumatoid arthritis by omitting intravenous contrast injection\u2014Does it change the assessment of inflammatory and destructive joint changes by the OMERACT RAMRIS?","volume":"36","author":"Ostergaard","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/mrm.22401","article-title":"Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semi-automated segmentation and semiquantitative assessment using contrast-enhanced fat-suppressed T1-weighted MRI","author":"Fotinos-Hoyer","year":"2010","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib81","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1148\/radiol.2521081706","article-title":"Rheumatoid arthritis: Evaluation with contrast-enhanced CT with digital bone masking","volume":"252","author":"Polster","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib82","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/rheumatology\/36.7.758","article-title":"Macrophage targeting with 99mTc-labelled J001 for scintigraphic assessment of experimental osteoarthritis in the rabbit","volume":"36","author":"Goupille","year":"1997","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib83","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/ard.47.6.485","article-title":"Inflammatory joint disease: A comparison of liposome scanning, bone scanning and radiography","volume":"47","author":"O'Sullivan","year":"1988","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib84","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1259\/bjr\/63780400","article-title":"Monitoring rheumatoid arthritis synovitis with 99mTc-anti-CD3","volume":"81","author":"Martins","year":"2008","journal-title":"Br J Radiol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib85","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/ard.49.2.88","article-title":"Measurement of joint inflammation in rheumatoid arthritis with indium-111 chloride","volume":"49","author":"Shmerling","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib86","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/00006231-199210000-00002","article-title":"Radioleucoscintigrpahy in osteoarthritis","volume":"13","author":"Al-Janabi","year":"1992","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib87","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/rheumatology\/33.1.67","article-title":"Joint scintigraphy for quantification of synovitis with 99mTc-labelled human immunoglobulin G compared to late phase scintigraphy with 99mTc-labelled diphosphonate","volume":"33","author":"de Bois","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib88","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.rcl.2009.04.005","article-title":"CT arthrography, MR arthrography, PET and scintigraphy in osteoarthritis","volume":"47","author":"Omoumi","year":"2009","journal-title":"Radiol Clin North Am"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib89","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2214\/ajr.185.3.01850797","article-title":"Diffuse FDG shoulder uptake on PET is associated with clinical findings of osteoarthritis","volume":"185","author":"Wandler","year":"2005","journal-title":"AJR Am J Roentogenol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib90","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.joca.2006.12.010","article-title":"Positron emission tomography with 18F-FDG in osteoarthritic knee","volume":"15","author":"Nakamura","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib91","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11307-007-0113-4","article-title":"2-Deoxy-2-[F-18]fluoro-D-glucose joint uptake on positron emission tomography images: rheumatoid arthritis versus osteoarthritis","volume":"9","author":"Elzinga","year":"2007","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.semarthrit.2010.12.003_bib92","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59745-401-8_1","article-title":"Imaging inflamed synovial joints","volume":"135","author":"Tan","year":"2007","journal-title":"Methods Mol Med"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017210002568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017210002568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T06:07:56Z","timestamp":1559974076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017210002568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":92,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0049017210002568"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2010.12.003","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}