{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:04:21Z","timestamp":1791180261450,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.semarthrit.2011.04.006","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T00:13:17Z","timestamp":1309047197000},"page":"415-423","source":"Crossref","is-referenced-by-count":137,"title":["Risk, Predictors, and Clinical Characteristics of Lymphoma Development in Primary Sj\u00f6gren's Syndrome"],"prefix":"10.1016","volume":"41","author":[{"given":"Roser","family":"Solans-Laqu\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"L\u00f3pez-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Angel Bosch-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Campillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Vilardell-Tarres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2011.04.006_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren's syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1001\/archinte.164.12.1275","article-title":"Clinical manifestations and early diagnosis of Sj\u00f6gren syndrome","volume":"164","author":"Kassan","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MD.0b013e318181e6af","article-title":"Primary Sj\u00f6gren syndrome in Spain: Clinical and immunological expression of 1010 patients","volume":"87","author":"Ramos-Casals","year":"2008","journal-title":"Medicine (Baltimore)"},{"issue":"Suppl 1","key":"10.1016\/j.semarthrit.2011.04.006_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02205560","article-title":"Anti-Ro (SS-A)\/La (SS-B) antibodies and Sjogren's syndrome","volume":"9","author":"Moutsopoulos","year":"1990","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/MD.0b013e3181b76ab5","article-title":"Hematologic manifestations and predictors of lymphoma development in Primary Sj\u00f6gren Syndrome","volume":"88","author":"Baimpa","year":"2009","journal-title":"Medicine"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib6","doi-asserted-by":"crossref","first-page":"888","DOI":"10.7326\/0003-4819-89-6-888","article-title":"Increased risk of lymphoma in sicca syndrome","volume":"89","author":"Kassan","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib7","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/1529-0131(199908)42:8<1765::AID-ANR28>3.0.CO;2-V","article-title":"Malignant lymphoma in primary Sj\u00f6gren's syndrome: a multicenter, retrospective, clinical study","volume":"42","author":"Voulgarelis","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/art.10221","article-title":"Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjogren's syndrome","volume":"46","author":"Ioannidis","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib9","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/ard.2005.041186","article-title":"Lymphoma and other malignancies in S\u00f6gren's syndrome: a cohort study on cancer incidence and lymphoma predictors","volume":"65","author":"Theander","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib10","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/rheumatology\/kem079","article-title":"Predicting adverse outcomes in primary Sj\u00f6grens's syndrome: identification of prognostic factors","volume":"46","author":"Brito-Zer\u00f3n","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0049-0172(96)80019-9","article-title":"Clinicopathological factors relating malignant lymphoma with Sj\u00f6gren's syndrome","volume":"25","author":"Anaya","year":"1996","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/art.1780390508","article-title":"Mixed monoclonal cryoglobulinemia and monoclonal rheumatoid factor cross-reactive idiotypes as predictive factors for the development of lymphoma in primary Sj\u00f6gren's syndrome","volume":"39","author":"Tzioufas","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.1780360309","article-title":"Preliminary criteria for the classification of Sjogren's syndrome","volume":"36","author":"Vitali","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib14","series-title":"Pathology and genetics: tumours of the hematopoietic and lymphoid tissues","year":"2001"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1200\/JCO.2006.09.2403","article-title":"Revised response criteria for malignant lymphoma","volume":"25","author":"Cheson","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"Oken","year":"1982","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib17","article-title":"GLOBOCAN 2000: Cancer incidence, mortality and prevalence worldwide (IARC Cancer Base No. 5)","year":"2001"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib18","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib19","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1001\/archinte.165.20.2337","article-title":"The risk of lymphoma development in autoimmune diseases","volume":"165","author":"Zintzaras","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00004728-200307000-00011","article-title":"Clinical and imaging findings of lymphoma in patients with Sj\u00f6gren syndrome","volume":"27","author":"Tonami","year":"2003","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/jnci\/djj004","article-title":"Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype","volume":"98","author":"Smebdy","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0049-0172(00)80016-5","article-title":"Clinical evolution, and morbidity and mortality of primary Sj\u00f6gren's syndrome","volume":"29","author":"Skopouli","year":"2000","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/rheumatology\/keh407","article-title":"Hypocomplementemia as an immunological marker of morbidity and mortality in patients with primary Sj\u00f6gren's syndrome","volume":"44","author":"Ramos-Casals","year":"2005","journal-title":"Rheumatol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molimm.2004.03.017","article-title":"The complement system in B cell regulation","volume":"41","author":"Carroll","year":"2004","journal-title":"Mol Immunol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/ar2210","article-title":"B cells in Sj\u00f6gren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue","volume":"9","author":"Hansen","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib26","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/1529-0131(199908)42:8<1673::AID-ANR16>3.0.CO;2-1","article-title":"Correlation of increased susceptibility to apoptosis of CD4+ T cells with lymphocyte activation and activity of disease in patients with primary Sj\u00f6gren's syndrome","volume":"42","author":"Zeher","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3109\/07853899809029932","article-title":"AIDS-related malignancies","volume":"4","author":"Smith","year":"1998","journal-title":"Ann Med"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/ard.60.11.1007","article-title":"Lymphomas complicating Sj\u00f6gren's syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulations of rheumatoid factor B cells","volume":"60","author":"Mariette","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/ard.60.5.467","article-title":"A longitudinal cohort study of Finnish patients with primary Sj\u00f6gren's syndrome: clinical, immunological and epidemiological aspects","volume":"60","author":"Pertovaara","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib30","first-page":"1050","article-title":"Correlation of serum B lymphocyte stimulator and B2 microglobulin with autoantibody secretion and systemic involvement in pSS","volume":"64","author":"Gottenberg","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib31","first-page":"207","article-title":"An improved prognostic parameter for non-Hodgkin's lymphoma based in the combination of three serum tumor markers","volume":"23","author":"Gui","year":"2008","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/art.1780400217","article-title":"Characterization of prelymphomatous stages of B cell lymphoproliferation in Sj\u00f6gren's syndrome","volume":"40","author":"De Vita","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib33","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/art.27564","article-title":"Significance of B cell clonality in Sj\u00f6gren's syndrome","volume":"62","author":"Youinou","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib34","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1182\/blood.V91.6.1864","article-title":"Clonal salivary gland infiltrates associated with myoepithelial sialadenitis (Sj\u00f6gren's syndrome) begin as nonmalignant antigen-selected expansion","volume":"91","author":"Bahler","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib35","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.4049\/jimmunol.179.7.4929","article-title":"Activation-induced cytidine-deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sj\u00f6gren's syndrome","volume":"179","author":"Bombardieri","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib36","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/annonc\/mdm513","article-title":"Ocular adnexal MALT lymphoma: an intriguing model for antigen-driven lymphomagenesis and microbial-targeted therapy","volume":"19","author":"Ferreri","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib37","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1182\/blood.V90.2.766","article-title":"Lymphomas in patients with Sj\u00f6gren's syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses","volume":"90","author":"Royer","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1084\/jem.174.3.525","article-title":"The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma","volume":"174","author":"Friedman","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib39","first-page":"1153","article-title":"Relationship between high grade lymphoma and low grade B-cell mucosa associated lymphoid tissue lymphoma (MALToma) of the stomach","volume":"136","author":"Chang","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2249.2007.03486.x","article-title":"Clonality analysis of lymphoproliferative disorders in patients with Sj\u00f6gren's syndrome","volume":"150","author":"Dong","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1034\/j.1600-0714.2003.00092.x","article-title":"Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sj\u00f6gren's syndrome","volume":"32","author":"Klussmann","year":"2003","journal-title":"Oral Pathol Med"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib42","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1346-8138.2000.tb02204.x","article-title":"Salivary gland MALT lymphoma associated with Helycobacter Pylori infection in a patient with Sj\u00f6gren's syndrome","volume":"27","author":"Nishimura","year":"2000","journal-title":"J Dermatol"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib43","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/jnci\/djh102","article-title":"Evidence for an association between Chlamydia psitacii and ocular adnexal lymphomas","volume":"96","author":"Ferreri","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1096\/fasebj.12.13.1255","article-title":"Molecular mimicry and immune-mediated diseases","volume":"12","author":"Oldstone","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib45","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM199405053301803","article-title":"Helicobacter pylori infection and gastric lymphoma","volume":"330","author":"Parsonnet","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.semarthrit.2011.04.006_bib46","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1532\/IJH97.06065","article-title":"Absence of chlamydial infection in Japanese patients with adnexal ocular lymphoma of mucosa-associated lymphoid tissue","volume":"85","author":"Yakushijin","year":"2007","journal-title":"Int J Hematol"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017211000953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017211000953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T20:05:18Z","timestamp":1592683518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017211000953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0049017211000953"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2011.04.006","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}