{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:24:47Z","timestamp":1789496687041,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","semarthritisrheumatism.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.semarthrit.2015.11.008","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T12:47:47Z","timestamp":1449060467000},"page":"S28-S33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":159,"special_numbering":"S","title":["Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys"],"prefix":"10.1016","volume":"45","author":[{"given":"Emmanuel","family":"Maheu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Reginster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2015.11.008_bib1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.semarthrit.2014.05.014","article-title":"An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"44","author":"Bruyere","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.joca.2010.09.014","article-title":"Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis\u2014meta-analysis","volume":"19","author":"Bannuru","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7326\/0003-4819-157-3-201208070-00473","article-title":"Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis","volume":"157","author":"Rutjes","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7326\/M14-1231","article-title":"Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis","volume":"162","author":"Bannuru","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/ard.2003.011742","article-title":"EULAR Recommendations 2003: an evidence-based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)","volume":"62","author":"Jordan","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/acr.21596","article-title":"American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee","volume":"64","author":"Hochberg","year":"2012","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005328.pub2","article-title":"Viscosupplementation for the treatment of osteoarthritis of the knee","author":"Bellamy","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.semarthrit.2013.10.002","article-title":"Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis: a systematic review and meta-analysis","volume":"43","author":"Bannuru","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4137\/CMAMD.S12743","article-title":"US-approved intra-articular hyaluronic acid injections are safe and effective in patients with knee osteoarthritis: systematic review and meta-analysis of randomized, saline-controlled trials","volume":"6","author":"Miller","year":"2013","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib11","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1002\/art.24925","article-title":"Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis","volume":"61","author":"Bannuru","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib12","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1001\/jama.290.23.3115","article-title":"Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis","volume":"290","author":"Lo","year":"2003","journal-title":"J.Am Med Assoc"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2106\/00004623-200403000-00012","article-title":"Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials","volume":"86-A","author":"Wang","year":"2004","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib14","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1503\/cmaj.1041203","article-title":"Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis","volume":"172","author":"Arrich","year":"2005","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib15","first-page":"758","article-title":"Hyaluronic acid injections relieve knee pain","volume":"54","author":"Modawal","year":"2005","journal-title":"J Fam Pract"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib16","first-page":"669","article-title":"Knee osteoarthritis: should your patient opt for hyaluronic acid injection?","volume":"55","author":"Medina","year":"2006","journal-title":"J Fam Pract"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib17","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/art.23103","article-title":"Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis","volume":"57","author":"Reichenbach","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF03261884","article-title":"Hyaluronic acid in the treatment of knee osteoarthritis: a systematic review and meta-analysis with emphasis on the efficacy of different products","volume":"26","author":"Colen","year":"2012","journal-title":"BioDrugs"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib19","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1136\/ard.2011.152017","article-title":"A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project","volume":"70","author":"Navarro-Sarabia","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/01.PHM.0000156899.18885.06","article-title":"Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience","volume":"84","author":"Petrella","year":"2005","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1055\/s-0030-1248072","article-title":"Clinical experience with the effectiveness and tolerability of hylan G-F 20 in 1047 patients with osteoarthritis of the knee","volume":"19","author":"Waddell","year":"2006","journal-title":"J Knee Surg"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib22","first-page":"258","article-title":"Intrarticular hyaluronic acid in the treatment of arthroses","volume":"45","author":"Kausch","year":"2009","journal-title":"Orthop\u00e4dische Praxis"},{"issue":"Suppl. 1","key":"10.1016\/j.semarthrit.2015.11.008_bib23","first-page":"S910","article-title":"Do hyaluronic acid injections delay total knee replacement surgery?","volume":"65","author":"Abbott","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.18553\/jmcp.2007.13.2.113","article-title":"Total knee replacement delayed with Hylan G-F 20 use in patients with grade IV osteoarthritis","volume":"13","author":"Waddell","year":"2007","journal-title":"J Manag Care Pharm"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib25","first-page":"6","article-title":"Cost-analysis of viscosupplementation treatment with hyaluronic acid in candidate knee replacement patients with osteoarthritis","volume":"57","author":"Mar","year":"2013","journal-title":"Rev Esp Cir Ortop Traumatol"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib26","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1136\/annrheumdis-2011-200972","article-title":"A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis","volume":"71","author":"Berenbaum","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib27","first-page":"946","article-title":"Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee","volume":"33","author":"Bagga","year":"2006","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/sarh.2002.33720","article-title":"Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?","volume":"32","author":"Ghosh","year":"2002","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/PL00005742","article-title":"Reduction of sensory responses to passive movements of inflamed knee joints by hylan, a hyaluronan derivative","volume":"116","author":"Pozo","year":"1997","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00270463","article-title":"The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment","volume":"7","author":"Smith","year":"1987","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib31","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.orthres.2005.05.003.1100230619","article-title":"Apoptosis and nitric oxide in an experimental model of osteoarthritis in rabbit after hyaluronic acid treatment","volume":"23","author":"Diaz-Gallego","year":"2005","journal-title":"J Orthop Res"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/1753425909340419","article-title":"Differential effect of molecular mass hyaluronan on lipopolysaccharide-induced damage in chondrocytes","volume":"16","author":"Campo","year":"2010","journal-title":"Innate Immun"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib33","first-page":"297","article-title":"The molecular weight of therapeutic hyaluronan (sodium hyaluronate): how significant is it?","volume":"21","author":"Aviad","year":"1994","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib34","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/rheumatology\/41.11.1240","article-title":"Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study","volume":"41","author":"Karlsson","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib35","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.joca.2005.09.003","article-title":"A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee","volume":"14","author":"Kirchner","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib36","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1002\/art.23026","article-title":"Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial","volume":"56","author":"Juni","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib37","first-page":"527","article-title":"Comparative efficacy and safety of two different molecular weight (MW) hyaluronans F60027 and Hylan G-F20 in symptomatic osteoarthritis of the knee (KOA). Results of a non inferiority, prospective, randomized, controlled trial","volume":"29","author":"Maheu","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib38","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.joca.2011.07.016","article-title":"Efficacy evaluation of highly purified intra-articular hyaluronic acid (Sinovial(R) vs hylan G-F20 [Synvisc(R)]) in the treatment of symptomatic knee osteoarthritis. A double-blind, controlled, randomized, parallel-group non-inferiority study","volume":"19","author":"Pavelka","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib39","first-page":"1579","article-title":"Viscosupplementation with hylan for the treatment of osteoarthritis: findings from clinical practice in Canada","volume":"23","author":"Lussier","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1297-319X(03)00005-8","article-title":"Factors predicting long-term efficacy of Hylan GF-20 viscosupplementation in knee osteoarthritis","volume":"70","author":"Conrozier","year":"2003","journal-title":"Joint Bone Spine"},{"issue":"Suppl. 9","key":"10.1016\/j.semarthrit.2015.11.008_bib41","first-page":"S158","article-title":"Evaluation of safety and efficacy of viscosupplementation in knee osteoarthritis with chondrocalcinosis","volume":"42","author":"Daumen-Legr\u00e9","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.semarthrit.2014.12.003","article-title":"Commentary on recent therapeutic guidelines for osteoarthritis","volume":"44","author":"Cutolo","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2015.11.008_bib43","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.2106\/00004623-200207000-00008","article-title":"Granulomatous inflammation after Hylan G-F 20 viscosupplementation of the knee: a report of six cases","volume":"84-A","author":"Chen","year":"2002","journal-title":"J Bone Joint Surg Am"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017215002863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017215002863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T05:01:50Z","timestamp":1599886910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017215002863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0049017215002863"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2015.11.008","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2015.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}