{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T07:17:21Z","timestamp":1693034241925},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.semarthrit.2017.08.010","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T02:32:11Z","timestamp":1504665131000},"page":"601-603","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["T-regulatory cells\u2014Triumph of perseverance: The Crafoord Prize for Polyarthritis in 2017"],"prefix":"10.1016","volume":"47","author":[{"given":"Frank A.","family":"Wollheim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2017.08.010_bib1","unstructured":"http:\/\/www.kva.se\/en\/publicerat\/the-crafoord-prize-1982-2016"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.semarthrit.2013.06.003","article-title":"The Crafoord Prize in Polyarthritis 2013: significant discoveries and remaining challenges","volume":"43","author":"Wollheim","year":"2013","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-3083.1988.tb02344.x","article-title":"Do suppressor T cells exist?","volume":"27","author":"M\u00f6ller","year":"1988","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib4","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.156.6.1577","article-title":"Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis","volume":"156","author":"Sakaguchi","year":"1982","journal-title":"J Exp Med"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1084\/jem.161.1.72","article-title":"Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease","volume":"161","author":"Sakaguchi","year":"1985","journal-title":"J Exp Med"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib6","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib7","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.162.9.5317","article-title":"Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic selftolerance","volume":"162","author":"Itoh","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib8","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1073\/pnas.45.4.554","article-title":"Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X\/O sex-chromosome constitution is female","volume":"45","author":"Russell","year":"1959","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib9","first-page":"1379","article-title":"X-linked lymphoreticular disease in the scurfy (sf) mutant mouse","volume":"138","author":"Godfrey","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri3650","article-title":"FOXP3 and scurfy: how it all began","volume":"14","author":"Ramsdell","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/83784","article-title":"Disruption of a new forkhead\/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse","volume":"27","author":"Bruno","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib13","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"H\u00e4ri","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ni1428","article-title":"Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice","volume":"8","author":"Kim","year":"2007","journal-title":"Nat Immunol"},{"issue":"3906","key":"10.1016\/j.semarthrit.2017.08.010_bib17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.166.3906.753","article-title":"Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice","volume":"166","author":"Nishizuka","year":"1969","journal-title":"Science"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/science.1160062","article-title":"CTLA-4 control over Foxp3+ regulatory T cell function","volume":"322","author":"Wing","year":"2008","journal-title":"Science"},{"issue":"6216","key":"10.1016\/j.semarthrit.2017.08.010_bib19","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1126\/science.aaa1292","article-title":"Detection of self-reactive CD87 T cells with an anergic phenotype in healthy individuals","volume":"346","author":"Maeda","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrrheum.2014.105","article-title":"TREG-cell therapies for autoimmune rheumatic diseases","volume":"10","author":"Miyara","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib21","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1080\/1744666X.2016.1199957","article-title":"Restoring regulation\u2014IL-2 therapy in systemic lupus erythematosus","volume":"12","author":"Humrich","year":"2016","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib22","unstructured":"Varga J, Trojanowska M, Kuwana M. Pathogenesis of systemic sclerosis: recent insight of molecular mechanisms and therapeutic opportunities. J Scleroderma Relat Dis. \u3008doi:105301\/jsrd.5000249\u3009"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.immuni.2005.01.016","article-title":"Regulatory T cell lineage specification by the forkhead transcription factor foxp3","volume":"22","author":"Fontenot","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1084\/jem.20062465","article-title":"Lack of Foxp3 function and expression in the thymic epithelium","volume":"204","author":"Liston","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.immuni.2004.07.009","article-title":"Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors","volume":"21","author":"Hsieh","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib26","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1084\/jem.20101235","article-title":"A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota","volume":"207","author":"Chinen","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib27","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1084\/jem.20101235","article-title":"A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota","volume":"207","author":"Chinen","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.semarthrit.2017.08.010_bib28","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017217305590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017217305590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:48:12Z","timestamp":1692971292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017217305590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0049017217305590"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2017.08.010","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T-regulatory cells\u2014Triumph of perseverance: The Crafoord Prize for Polyarthritis in 2017","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2017.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}