{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:34:07Z","timestamp":1790685247172,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.semarthrit.2019.06.019","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T02:01:54Z","timestamp":1561773714000},"page":"166-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Torque teno virus viremia in patients with chronic arthritis: Influence of biologic therapies"],"prefix":"10.1016","volume":"50","author":[{"given":"Mar\u00eda","family":"Mart\u00edn-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliseo","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Fern\u00e1ndez-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidoro","family":"Gonz\u00e1lez-\u00c1lvaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Pablos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.semarthrit.2019.06.019_bib0001","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s13075-015-0880-2","article-title":"Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials","volume":"17","author":"Strand","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0002","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0140-6736(14)61704-9","article-title":"The risk of serious infection with biologics in treating patients with rheumatoid arthritis: a systematic review and metaanalysis","volume":"386","author":"Singh","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0003","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/ard.2010.146365","article-title":"The comparative risk of serious infections among rheumatoid arthritis patients starting or switching biological agents","volume":"70","author":"Curtis","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0004","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.berh.2015.05.009","article-title":"Risk of infection with biologic antirheumatic therapies in patients with rheumatoid arthritis","volume":"29","author":"Lahiri","year":"2015","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0005","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.cmi.2018.01.029","article-title":"ESCMID study group for infections in compromised hosts (ESGICH) consensus document on the safety of targeted and biological therapies: an infectious diseases perspective (introduction)","volume":"24","author":"Fern\u00e1ndez-Ruiz","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0006","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.cell.2013.10.034","article-title":"Temporal response of the human virome to immunosuppression and antiviral therapy","volume":"155","author":"De Vlaminck","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0007","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1099\/vir.0.046862-0","article-title":"Antigenic diversity and seroprevalences of torque teno viruses in children and adults by ORF2-based immunoassays","volume":"94","author":"Chen","year":"2013","journal-title":"J Gen Virol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0008","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.virol.2009.08.036","article-title":"Torque teno virus DNA drives proinflammatory cytokines production and secretion by immune cells via toll-like receptor 9","volume":"394","author":"Rocchi","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0009","first-page":"1","article-title":"History of discoveries and pathogenicity of TT viruses","volume":"331","author":"Okamoto","year":"2009","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0010","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1432-2277.2008.00714.x","article-title":"Torque teno virus: any pathological role in liver transplanted patients?","volume":"21","author":"Burra","year":"2008","journal-title":"Transplant Int"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0011","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/bbrc.1997.7765","article-title":"A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology","volume":"241","author":"Nishizawa","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0012","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00705-009-0547-x","article-title":"Ratification vote on taxonomic proposals to the international committee on taxonomy of viruses (2009)","volume":"155","author":"Carstens","year":"2010","journal-title":"Arch Virol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0013","series-title":"Encyclopedia of virology","first-page":"104","article-title":"Anellovirus","author":"Biagini","year":"2008"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0014","doi-asserted-by":"crossref","first-page":"9716","DOI":"10.1007\/s11357-014-9716-2","article-title":"TTV DNA plasma load and its association with age, gender, and HCMV IgG serostatus in healthy adults","volume":"36","author":"Haloschan","year":"2014","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0015","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.cmi.2016.04.007","article-title":"Torquetenovirus: the human virome from bench to bedside","volume":"22","author":"Focosi","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0016","doi-asserted-by":"crossref","first-page":"e98819","DOI":"10.1371\/journal.pone.0098819","article-title":"Reactivation of multiple viruses in patients with sepsis","volume":"9","author":"Walton","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmv.20756","article-title":"Progression towards AIDS leads to increased torque teno virus and torque teno minivirus titers in tissues of HIV infected individuals","volume":"79","author":"Thom","year":"2007","journal-title":"J Med Virol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0018","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/829584","article-title":"Emergence of exhausted B cells in asymptomatic HIV-1-infected patients na\u00efve for HAART is related to reduced immune surveillance","volume":"2012","author":"Fogli","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0019","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jcv.2015.09.004","article-title":"Virome analysis of antiretroviral-treated HIV patients shows no correlation between T-cell activation and anelloviruses levels","volume":"72","author":"Li","year":"2015","journal-title":"J Clin Virol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2001.tb03868.x","article-title":"Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients","volume":"945","author":"Zhong","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0021","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1097\/TP.0b013e31817615e6","article-title":"Changes in CD8+57+ T lymphocyte expansions after autologous hematopoietic stem cell transplantation correlate with changes in torquetenovirus viremia","volume":"85","author":"Maggi","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0022","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/bmt.2015.262","article-title":"Torque teno virus in patients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies","volume":"51","author":"Masouridi-Levrat","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122975","article-title":"Pre-transplant plasma torque teno virus load and increase dynamics after lung transplantation","volume":"10","author":"Gorzer","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0024","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/infdis\/jit423","article-title":"Torque teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen","volume":"209","author":"Beland","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0025","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/infdis\/jiu209","article-title":"Torquetenovirus (TTV) viremia correlates with intensity of maintenance immunosuppression in adult orthotopic liver transplantation","volume":"210","author":"Focosi","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0026","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.healun.2013.12.007","article-title":"Plasma DNA levels of torque teno virus and immunosuppression after lung transplantation","volume":"33","author":"Gorzer","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0027","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/infdis\/jiy306","article-title":"Quantification of torque teno virus viremia as a prospective biomarker for infectious disease in kidney allograft recipients","volume":"218","author":"Strassl","year":"2018","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0028","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/TP.0000000000001455","article-title":"Torque teno virus load-inverse association with antibody-mediated rejection after kidney transplantation","volume":"101","author":"Schiemann","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0029","article-title":"Monitoring of alphatorquevirus DNA levels for the prediction of immunosuppression-related complications after kidney transplantation","author":"Fern\u00e1ndez-Ruiz","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.autrev.2006.03.002","article-title":"Possible pathogenic nature of the recently discovered TT virus. Does it play a role in autoimmune rheumatic diseases?","volume":"6","author":"Gergely Jr","year":"2006","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0031","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/art.1780380107","article-title":"Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis","volume":"38","author":"Prevoo","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0032","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/ard.2008.094870","article-title":"Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis","volume":"68","author":"Lukas","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0033","first-page":"S93","article-title":"The disease activity score and the EULAR response criteria","volume":"23","author":"Fransen","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0034","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/ard.2010.138594","article-title":"Ankylosing spondylitis disease activity score (ASDAS): defining cut-off values for disease activity states and improvement scores","volume":"70","author":"Machado","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/bmt.2017.235","article-title":"The kinetics of torque teno virus plasma DNA load shortly after engraftment predicts the risk of high-level CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients","volume":"53","author":"Albert","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0036","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jcv.2017.07.001","article-title":"Dynamics of torque teno virus plasma DNAemia in allogeneic stem cell transplant recipients","volume":"94","author":"Albert","year":"2017","journal-title":"J Clin Virol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0037","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/TP.0b013e31827a4bd6","article-title":"Epstein-Barr virus DNAemia is an early surrogate marker of the net state of immunosuppresion in solid organ transplant recipients","volume":"95","author":"San-Juan","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0038","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/TP.0000000000000306","article-title":"Utility of a monitoring strategy for human herpesviruses 6 and 7 viremia after liver transplantation: a randomized clinical trial","volume":"99","author":"Fern\u00e1ndez-Ruiz","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0039","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/rheumatology\/kep101","article-title":"Methotrexate, rheumatoid arthritis and infection risk: what is the evidence?","volume":"48","author":"McLean-Tooke","year":"2009","journal-title":"Rheumatology"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0040","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1136\/annrheumdis-2016-210708","article-title":"Safety of synthetic and biological DMARDs: a systematic literature review informing the 2016 update of the EULAR recommendations for management of rheumatoid arthritis","volume":"76","author":"Ramiro","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0041","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1310\/8C94-VYPQ-NG1H-4CNW","article-title":"TTV viral load as a marker for immune reconstitution after initiation of HAART in HIV-infected patients","volume":"3","author":"Madsen","year":"2002","journal-title":"HIV Clin Trials"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0042","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2018-000723","article-title":"Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial","volume":"4","author":"Mease","year":"2018","journal-title":"RMD Open"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0043","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3899\/jrheum.170429","article-title":"Efficacy and safety of ixekizumab in patients with active psoriatic arthritis: 52-week results from a phase III study (SPIRIT-P1)","volume":"45","author":"Van der Heijde","year":"2018","journal-title":"J Rheumatol"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0044","doi-asserted-by":"crossref","first-page":"36923","DOI":"10.1038\/srep36923","article-title":"Controlled mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNF\u03b1 neutralization","volume":"6","author":"Segueni","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0045","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/infdis\/jiy452","article-title":"Torque teno virus as a novel biomarker targeting the efficacy of immunosuppression after lung transplantation","volume":"218","author":"Jaksch","year":"2018","journal-title":"J Infect Dis"},{"key":"10.1016\/j.semarthrit.2019.06.019_bib0046","article-title":"Kinetics of torque teno virus-DNA plasma load predict rejection in lung transplant recipients","author":"Frye","year":"2018","journal-title":"Transplantation"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017219302781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017219302781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:02:06Z","timestamp":1758733326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017219302781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0049017219302781"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2019.06.019","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Torque teno virus viremia in patients with chronic arthritis: Influence of biologic therapies","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2019.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}