{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T09:39:54Z","timestamp":1775381994642,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.semarthrit.2020.01.007","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T15:50:48Z","timestamp":1580226648000},"page":"553-556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pregnancy success rate and response to heparins and\/or aspirin differ in women with antiphospholipid antibodies according to their Global AntiphosPholipid Syndrome Score"],"prefix":"10.1016","volume":"50","author":[{"given":"M.","family":"Radin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Cecchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rubini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Roccatello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Cuadrado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sciascia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1_suppl","key":"10.1016\/j.semarthrit.2020.01.007_bib0001","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/0961203318801746","article-title":"Management of pregnancy in systemic lupus erythematosus: what a GP should know","volume":"27","author":"Jordan","year":"2018","journal-title":"Lupus [Internet]"},{"issue":"2","key":"10.1016\/j.semarthrit.2020.01.007_bib0002","article-title":"A national study of the complications of lupus in pregnancy","volume":"199","author":"Clowse","year":"2008","journal-title":"Am J Obstet Gynecol [Internet]"},{"issue":"5","key":"10.1016\/j.semarthrit.2020.01.007_bib0003","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrrheum.2015.29","article-title":"The clinical spectrum of autoimmune congenital heart block","volume":"11","author":"Brito-Zer\u00f3n","year":"2015","journal-title":"Nat Rev Rheumatol [Internet]"},{"issue":"6","key":"10.1016\/j.semarthrit.2020.01.007_bib0004","doi-asserted-by":"crossref","DOI":"10.1097\/GCO.0000000000000406","article-title":"Current insights in obstetric antiphospholipid syndrome","volume":"29","author":"Schreiber","year":"2017","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.semarthrit.2020.01.007_bib0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost [Internet]"},{"issue":"1","key":"10.1016\/j.semarthrit.2020.01.007_bib0006","doi-asserted-by":"crossref","DOI":"10.1007\/s11739-016-1596-2","article-title":"Novel diagnostic and therapeutic frontiers in thrombotic anti-phospholipid syndrome","volume":"12","author":"Sciascia","year":"2017","journal-title":"Intern Emerg Med"},{"issue":"25","key":"10.1016\/j.semarthrit.2020.01.007_bib0007","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1182\/blood-2011-02-339234","article-title":"First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss","volume":"117","author":"Bramham","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.semarthrit.2020.01.007_bib0008","doi-asserted-by":"crossref","unstructured":"Sciascia S, Hunt BJJ, Talavera-Garcia E, Lliso G, Khamashta MAA, Cuadrado MJJ. The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. 2016;214(2):273.e1-8.","DOI":"10.1016\/j.ajog.2015.09.078"},{"issue":"3","key":"10.1016\/j.semarthrit.2020.01.007_bib0009","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijgo.2008.11.010","article-title":"Low-molecular-weight heparin versus intravenous immunoglobulin for recurrent abortion associated with antiphospholipid antibody syndrome","volume":"104","author":"Dendrinos","year":"2009","journal-title":"Int J Gynecol Obstet [Internet]"},{"issue":"8","key":"10.1016\/j.semarthrit.2020.01.007_bib0010","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/rheumatology\/kes388","article-title":"GAPSS: the global anti-phospholipid syndrome score","volume":"52","author":"Sciascia","year":"2013","journal-title":"Rheumatology (Oxford) [Internet]"},{"key":"10.1016\/j.semarthrit.2020.01.007_bib0011","article-title":"Clinical utility of the global antiphospholipid syndrome score (GAPSS) for risk stratification: a pooled analysis","author":"Sciascia","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.semarthrit.2020.01.007_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2017.12.006","article-title":"Extra-criteria manifestations of antiphospholipid syndrome: risk assessment and management","author":"Radin","year":"2018","journal-title":"Semin Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.semarthrit.2020.01.007_bib0013","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.semarthrit.2020.01.007_bib0030","doi-asserted-by":"crossref","DOI":"10.1081\/PRG-100104165","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens Pregnancy"},{"issue":"6","key":"10.1016\/j.semarthrit.2020.01.007_bib0014","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham heart study","volume":"117","author":"D'Agostino","year":"2008","journal-title":"Circulation [Internet]"},{"issue":"215_","key":"10.1016\/j.semarthrit.2020.01.007_bib0015","first-page":"22","article-title":"Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1987","volume":"68","author":"Harris","year":"1986","journal-title":"Clin Exp Immunol"},{"issue":"12","key":"10.1016\/j.semarthrit.2020.01.007_bib0016","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/rheumatology\/35.12.1239","article-title":"Specificity of ELISA for antibody to beta 2-glycoprotein I in patients with antiphospholipid syndrome","volume":"35","author":"Amengual","year":"1996","journal-title":"Br J Rheumatol [Internet]"},{"issue":"4","key":"10.1016\/j.semarthrit.2020.01.007_bib0017","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1055\/s-0038-1649901","article-title":"Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the subcommittee on lupus anticoagulant\/antiphospholipid antibody of the scientific and standardisation committee of the ISTH","volume":"74","author":"Brandt","year":"1995","journal-title":"Thromb Haemost [Internet]."},{"issue":"10","key":"10.1016\/j.semarthrit.2020.01.007_bib0018","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","article-title":"Update of the guidelines for lupus anticoagulant detection","volume":"7","author":"Pengo","year":"2009","journal-title":"J Thromb Haemost [Internet]"},{"key":"10.1016\/j.semarthrit.2020.01.007_bib0019","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2019-215213","article-title":"EULAR recommendations for the management of antiphospholipid syndrome in adults","author":"Tektonidou","year":"2019","journal-title":"Ann Rheum Dis [Internet]"},{"issue":"1","key":"10.1016\/j.semarthrit.2020.01.007_bib0020","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2019-000924","article-title":"Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the Eular recommendations for the management of antiphospholipid syndrome in adults","volume":"5","author":"Tektonidou","year":"2019","journal-title":"RMD Open"},{"issue":"2","key":"10.1016\/j.semarthrit.2020.01.007_bib0021","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1160\/th15-06-0491","article-title":"The efficacy of hydroxychloroquine in altering pregnancy outcome in women with antiphospholipid antibodies. Evidence and clinical judgment","volume":"115","author":"Sciascia","year":"2016","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1016\/j.semarthrit.2020.01.007_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001013","article-title":"Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. M. Fisk N, editor","volume":"8","author":"Salmon","year":"2011","journal-title":"PLoS Med"},{"issue":"1","key":"10.1016\/j.semarthrit.2020.01.007_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2015-000131","article-title":"Lupus anticoagulant is the main predictor of adverse pregnancy outcomes in aPL-positive patients: validation of PROMISSE study results","volume":"3","author":"Yelnik","year":"2016","journal-title":"Lupus Sci Med"},{"issue":"1","key":"10.1016\/j.semarthrit.2020.01.007_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2015.09.066","article-title":"Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study","volume":"214","author":"Kim","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"10.1016\/j.semarthrit.2020.01.007_bib0027","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/acr.22388","article-title":"Thrombotic risk assessment in systemic lupus erythematosus: validation of the global antiphospholipid syndrome score in a prospective cohort","volume":"66","author":"Sciascia","year":"2014","journal-title":"Arthritis Care Res"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004901722030007X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004901722030007X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:03:37Z","timestamp":1758733417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004901722030007X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S004901722030007X"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2020.01.007","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy success rate and response to heparins and\/or aspirin differ in women with antiphospholipid antibodies according to their Global AntiphosPholipid Syndrome Score","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2020.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}