{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:17:45Z","timestamp":1791811065045,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014468","name":"Mallinckrodt Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014468","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019175","name":"Scleroderma Society of Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013455","name":"Lady Davis Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Arthritis and Rheumatism"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.semarthrit.2021.01.001","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T13:00:44Z","timestamp":1610110844000},"page":"318-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trigeminal neuralgia in systemic sclerosis"],"prefix":"10.1016","volume":"51","author":[{"given":"Nancy","family":"Maltez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Y","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Troyanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mianbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie","family":"Jantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin J.","family":"Fritzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.semarthrit.2021.01.001_bib0001","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/ard.2010.135772","article-title":"Involvement of functional autoantibodies against vascular receptors in systemic sclerosis","volume":"70","author":"Riemekasten","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.semarthrit.2021.01.001_bib0002","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ijom.2018.02.006","article-title":"The psychosocial impact of orofacial pain in trigeminal neuralgia patients: a systematic review","volume":"47","author":"Melek","year":"2018","journal-title":"Int J Clin Oral Maxillofac Surg"},{"issue":"5","key":"10.1016\/j.semarthrit.2021.01.001_bib0003","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/RHU.0b013e3181e928e6","article-title":"Clues for previously undiagnosed connective tissue disease in patients with trigeminal neuralgia","volume":"16","author":"Nascimento","year":"2010","journal-title":"J Clin Rheumatol"},{"key":"10.1016\/j.semarthrit.2021.01.001_bib0004","unstructured":"Scardina G.A., Mazzullo M., Messina P. [Early diagnosis of progressive systemic sclerosis: the role of oro-facial phenomena]. Minerva Stomatol 51(7\u20138):311\u20137."},{"issue":"1","key":"10.1016\/j.semarthrit.2021.01.001_bib0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0002-9343(82)90926-3","article-title":"Trigeminal neuropathy in progressive systemic sclerosis","volume":"73","author":"Farrell","year":"1982","journal-title":"Am J Med"},{"issue":"5","key":"10.1016\/j.semarthrit.2021.01.001_bib0006","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/acr.22739","article-title":"Relationship between disease characteristics and oral radiologic findings in systemic sclerosis: results from a Canadian oral health study","volume":"68","author":"Baron","year":"2016","journal-title":"Arthritis Care Res"},{"issue":"4","key":"10.1016\/j.semarthrit.2021.01.001_bib0007","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1259\/dmfr.25.4.9084272","article-title":"Orofacial radiological manifestations of systemic sclerosis","volume":"25","author":"Rout","year":"1996","journal-title":"Dentomaxillofac Radiol"},{"issue":"4","key":"10.1016\/j.semarthrit.2021.01.001_bib0008","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1067\/moe.2000.108798","article-title":"Painful trigeminal neuropathy caused by severe mandibular resorption and nerve compression in a patient with systemic sclerosis: case report and literature review","volume":"90","author":"Fischoff","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"4","key":"10.1016\/j.semarthrit.2021.01.001_bib0009","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0901-5027(95)80025-5","article-title":"Mandibular resorption due to systemic sclerosis. Case report of surgical correction of a secondary open bite deformity","volume":"24","author":"Haers","year":"1995","journal-title":"Int J Clin Oral Maxillofac Surg"},{"issue":"10","key":"10.1016\/j.semarthrit.2021.01.001_bib0010","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tibs.2005.08.003","article-title":"The nuclear membrane proteome: extending the envelope","volume":"30","author":"Schirmer","year":"2005","journal-title":"Trends Biochem Sci"},{"issue":"24","key":"10.1016\/j.semarthrit.2021.01.001_bib0011","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/MD.0000000000000223","article-title":"An autoimmune myositis-overlap syndrome associated with autoantibodies to nuclear pore complexes: description and long-term follow-up of the Anti-Nup Syndrome","volume":"93","author":"Sen\u00e9cal","year":"2014","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"10.1016\/j.semarthrit.2021.01.001_bib0012","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/acr.22451","article-title":"2013 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for Systemic Sclerosis Outperform the 1980 Criteria: data From the Canadian Scleroderma Research Group","volume":"67","author":"Alhajeri","year":"2015","journal-title":"Arthritis Care Res"},{"issue":"4","key":"10.1016\/j.semarthrit.2021.01.001_bib0013","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/acr.21583","article-title":"Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis","volume":"64","author":"Steele","year":"2012","journal-title":"Arthritis Care Res"},{"issue":"7","key":"10.1016\/j.semarthrit.2021.01.001_bib0014","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1136\/annrheumdis-2018-214436","article-title":"Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective","volume":"78","author":"Damoiseaux","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.semarthrit.2021.01.001_bib0015","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/art.1780311017","article-title":"A novel autoantibody causing a peripheral fluorescent antinuclear antibody pattern is specific for nuclear pore complexes","volume":"31","author":"Dagenais","year":"1988","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.semarthrit.2021.01.001_bib0016","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00109-004-0554-z","article-title":"Autoantigens of the nuclear pore complex","volume":"82","author":"Enarson","year":"2004","journal-title":"J Mol Med"},{"issue":"2","key":"10.1016\/j.semarthrit.2021.01.001_bib0017","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2249.2004.02432.x","article-title":"The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence","volume":"136","author":"OU","year":"2004","journal-title":"Clin Exp Neuroimmunol"},{"issue":"1","key":"10.1016\/j.semarthrit.2021.01.001_bib0018","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2296-9-26","article-title":"Primary care incidence and treatment of four neuropathic pain conditions: a descriptive study, 2002\u20132005","volume":"9","author":"Hall","year":"2008","journal-title":"BMC Fam Pract"},{"issue":"4","key":"10.1016\/j.semarthrit.2021.01.001_bib0019","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/123.4.665","article-title":"The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK","volume":"123","author":"MacDonald","year":"2000","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.semarthrit.2021.01.001_bib0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000247422","article-title":"Carpal tunnel syndrome and systemic sclerosis","volume":"185","author":"Machet","year":"1992","journal-title":"Dermatology"},{"issue":"10","key":"10.1016\/j.semarthrit.2021.01.001_bib0021","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/ard.2005.038935","article-title":"Distal degeneration of sensory and autonomic cutaneous nerve fibres in systemic sclerosis","volume":"64","author":"Provitera","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.semarthrit.2021.01.001_bib0022","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/rheumatology\/kem251","article-title":"Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation","volume":"46","author":"Provitera","year":"2007","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.semarthrit.2021.01.001_bib0023","first-page":"1203","article-title":"Autonomic nervous system and smooth muscle cell involvement in systemic sclerosis: ultrastructural study of 3 cases","volume":"27","author":"Malandrini","year":"2000","journal-title":"J Rheumatol"},{"issue":"2","key":"10.1016\/j.semarthrit.2021.01.001_bib0024","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrm.2016.147","article-title":"The nuclear pore complex: understanding its function through structural insight","volume":"18","author":"Beck","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"10.1016\/j.semarthrit.2021.01.001_bib0025","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s00018-019-03037-0","article-title":"Nuclear pore protein TPR associates with lamin B1 and affects nuclear lamina organization and nuclear pore distribution","volume":"76","author":"Fi\u0161erov\u00e1","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"10.1016\/j.semarthrit.2021.01.001_bib0026","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.clinre.2013.10.008","article-title":"Autoantibodies in primary biliary cirrhosis: antinuclear envelope autoantibodies","volume":"38","author":"Chantran","year":"2014","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"1","key":"10.1016\/j.semarthrit.2021.01.001_bib0027","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/hep.21472","article-title":"Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis","volume":"45","author":"Nakamura","year":"2007","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.semarthrit.2021.01.001_bib0028","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/rheumatology\/kev300","article-title":"Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease","volume":"55","author":"Gunnarsson","year":"2015","journal-title":"Rheumatology"},{"issue":"2","key":"10.1016\/j.semarthrit.2021.01.001_bib0029","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1186\/ar3763","article-title":"Clinical significance of antibodies to Ro52\/TRIM21 in systemic sclerosis","volume":"14","author":"Hudson","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"10.1016\/j.semarthrit.2021.01.001_bib0030","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00296-017-3718-1","article-title":"A review of the role and clinical utility of anti-Ro52\/TRIM21 in systemic autoimmunity","volume":"37","author":"Lee","year":"2017","journal-title":"Rheumatol Int"},{"issue":"7","key":"10.1016\/j.semarthrit.2021.01.001_bib0031","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/annrheumdis-2018-215004","article-title":"Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis","volume":"78","author":"Sabbagh","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.semarthrit.2021.01.001_bib0032","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12931-019-1231-7","article-title":"Presentations and outcomes of interstitial lung disease and the anti-Ro52 autoantibody","volume":"20","author":"Sclafani","year":"2019","journal-title":"Respir Res"},{"issue":"4","key":"10.1016\/j.semarthrit.2021.01.001_bib0033","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/acr.21583","article-title":"Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis","volume":"64","author":"Steele","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Seminars in Arthritis and Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017221000019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049017221000019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:07:32Z","timestamp":1758733652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049017221000019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0049017221000019"],"URL":"https:\/\/doi.org\/10.1016\/j.semarthrit.2021.01.001","relation":{},"ISSN":["0049-0172"],"issn-type":[{"value":"0049-0172","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trigeminal neuralgia in systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Seminars in Arthritis and Rheumatism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.semarthrit.2021.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}